Permanent Magnets to Enable Highly-Targeted Drug Delivery Applications: A Computational and Experimental Study

Mercado-M, M.; Cruz, Juan C.

doi:10.1007/978-981-10-4086-3_140

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Future work includes the design and validation of a model for the guided transport of magnetic nanocarriers in fluidic devices, which requires the simultaneous study of fluid flow mechanics in small arteries and manipulation of magnetic fields with the aid of permanent magnets [18]. This will be the basis for designing highly-targeted therapies for brain diseases via intrathecal or intravenous administration.…”

Section: Resultsmentioning

confidence: 99%

CFD Simulation and Validation of Flow in Small Arteries to Enable Further Drug Delivery Studies

Montoya

Cruz

2019

redin

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Treatments based on nanocarriers such as nanoparticles have emerged as alternatives to overcome common limitations and side effects caused by traditional treatments against cancer and neurological diseases. The main attribute of nanoparticles stems from the fact that they can transport pharmacological agents in a guided manner. This allows drugs to selectively target diseased rather than healthy tissues. This work was aimed at modeling and simulating fluid flow inside small arteries and experimentally validating the model through quantitative measurements of pressure and flow rates. The validity of the model was evaluated in the light of different indexes of percentage agreement between simulated and measured values. The model was previously verified via mesh convergence analysis and qualitative observations of velocity profile. Our findings provide a robust basis for studying nanoparticle transport in arteries as the developed platform enables their releasing and remote manipulation both in silico and in vitro.

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Section: Resultsmentioning

confidence: 99%

CFD Simulation and Validation of Flow in Small Arteries to Enable Further Drug Delivery Studies

Montoya

Cruz

2019

redin

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Evidence-based impact by clinical engineers on global patients outcomes

David¹,

Judd²

2019

Health Technol.

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The intersection of technological changes and societal evolution has transformed every aspect of human life. Technological advancements are transforming how healthcare knowledge is expanding and accelerating the outreach of critical medical services delivery (Jamal et al. in Health Information Management Journal 38(3):26-37, 2009). While this transformation facilitates new opportunities simultaneously it also introduces challenges (Jacobzone and Oxley, 2001). Appropriate Health Technology (HT) is vital to new and existing global health care programs. Therefore, qualified professionals who can safely guide the development, evaluation, installation, integration, performance assurance, and risk mitigation of HT must be in position to lead. Trained Clinical Engineers (CE) and Biomedical Engineers (BE) have been recognized by the World Health Organization (WHO) as the essential practitioners to providing this critically needed guidance. Over the past four years, a senior professional group participated in an international project that seeks evidence for the hypothesis-that the engagement of CE and BE in guiding HTimpacts positively on patient outcomes, while the alternative is that there is no difference. The group collected published data that was subjected to peer review screening; additional data qualification conditions are described in this paper. The project was initiated at the Global CE Summit during the first International Clinical Engineering and Health Technology Management Congress (ICEHTMC) in Hangzhou, China in October 2015 (Global Clinical Engineering Summit at the First International Clinical Engineering and Health Technology Management Congress, 2015). Following the adoption of a resolution to investigate CE contributions to the improvement of world health status, an international survey and literature survey were initiated. During the first two years of this project 150 case studies from 90 countries were identified covering the previous ten years. The results of this survey were presented to health leaders at the World Health Organization (WHO) World Health Assembly in 2016. Last year, 250 case studies were added including 35 more countries covering the 2016-2017 period. The combined project contains 400 qualified submissions from 125 countries. The conclusion was that engagement of CE and BME is critical for successful investment in HT and for achieving intended patient outcomes. This paper describes the project's plan, the results of the literature review performed, and the evidence identified during the process.

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A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries

Kiwumulo

Muwonge

Ibingira

et al. 2021

MBE

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<abstract> <p>Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised to aid planning before a specific treatment is administered. In such approaches, precise treatment, as it is the case in radiotherapy, is used to administer a maximum dose to the infected regions while minimizing the effect on normal tissue. Complicated cancers such as leukemia present even greater challenges due to their presentation in liquid form and not being localised in one area. As such, science has led to the development of targeted drug delivery, where the infected cells can be specifically targeted anywhere in the body.</p> <p>Despite the great prospects and advances of these modeling and simulation tools in the design and delivery of targeted drugs, their use by Low and Middle Income Countries (LMICs) researchers and clinicians is still very limited. This paper therefore reviews the modeling and simulation approaches for leukemia treatment using nanoparticles as an example for virtual experimentation. A systematic review from various databases was carried out for studies that involved cancer treatment approaches through modeling and simulation with emphasis to data collected from LMICs. Results indicated that whereas there is an increasing trend in the use of modeling and simulation approaches, their uptake in LMICs is still limited. According to the review data collected, there is a clear need to employ these tools as key approaches for the planning of targeted drug treatment approaches.</p> </abstract>

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Permanent Magnets to Enable Highly-Targeted Drug Delivery Applications: A Computational and Experimental Study

Cited by 3 publications

References 12 publications

CFD Simulation and Validation of Flow in Small Arteries to Enable Further Drug Delivery Studies

CFD Simulation and Validation of Flow in Small Arteries to Enable Further Drug Delivery Studies

Evidence-based impact by clinical engineers on global patients outcomes

A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries

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