Magnetic nanofibers based bandage for skin cancer treatment: a non‐invasive hyperthermia therapy

Abstract

Background The treatment of non‐melanoma skin cancer and deadliest malignant melanoma skin cancer are the fifth and ninth most expensive treatments in Medicare, respectively. Moreover, the recurrence of cancer after currently available therapies, that is, surgery or radiotherapy, reduces the patient's life expectancy. Aims In view of this, we fabricated magnetic nanofibrous mat‐based bandage to treat skin cancer non‐invasively using an external alternating current (AC) magnetic field induced hyperthermia. Methods The Fe3O4 nanoparticles incorporated polycaprolactone (PCL) fibers based bandages were fabricated using the electrospinning technique. The efficacy of the bandage was investigated in vitro using parental/doxorubicin hydrochloride (Dox)‐resistant HeLa cells and in vivo using BALB/c mouse model in the presence of an external AC magnetic field (AMF). Results The PCL‐Fe3O4 fibrous mat‐based bandages dissipate heat energy locally on the application of an external AMF and increase the surrounding temperature in a controlled way up to 45°C in a few mins. The in vitro study confirms the elevated temperature could kill parental and Dox‐resistant HeLa cells significantly. As the activity of Dox enhanced at a higher temperatures, more than 85% of parental HeLa cells were dead when cells incubated with Dox contained fibrous mat in the presence of AMF for 10 minutes. Further, we confirm the full recovery of chemically induced skin tumors on BALB/c mice within a month after five hyperthermic doses for 15 minutes. Also, there was no sign of inflammation and recurrence of cancer post‐therapy. Conclusion The present study confirms the PCL‐Fe3O4 nanofibrous based bandages are unique and compelling to treat skin cancer.

Flexible Skin Patch Enabled Tumor Hybrid Thermophysical Therapy and Adaptive Antitumor Immune Response

“…In general, these magnetic particles can be applied though intravenous administration or mix with other polymers or fibers as bandages. [ 18 ] The fabrication of fibers involves electrospinning technique where large equipment is needed. In comparison with the flexible bandages, liquid metal enabled skin patch can provide a facile fabrication and a direct printing method to be used on skin.…”

Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment

“…In vivo tests confirmed the full recovery of chemically induced skin tumors on BALB/c mice within a month after five hyperthermic doses for 15 min. There were also no signs of post-therapy inflammation and cancer recurrence [ 74 ].…”

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

“…DOX release was studied under physiological and acidic pH in the absence or presence of applied magnetic fields, respectively, revealing that the maximum cytotoxicity on cancer cells (83%) could be obtained at day seven by magnetically stimulating nanofibers with chitosan/PCL/nickel ferrite 10 wt.% composition. Another group fabricated a magnetic nanofibrous mat-based bandage for the treatment of skin cancer by non-invasive induction of hyperthermia [128]. PCL fibers incorporating magnetite nanoparticles were obtained by electrospinning and then magnetically stimulated with an external alternating current magnetic field.…”