Magnetic nanocomposites based on hypercrosslinked polystyrenes

Пастухов, А. В.; Davankov, V. A.; Волков, В. В.; Zubavichus, Ya. V.; Korlyukov, Alexander A.; Филатова, А. Г.

doi:10.3103/s1062873809040078

Cited by 10 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This material is a biporous polymer having a large number of micropores with a diameter of 1.5-3 nm and macropores with a diameter of up to 100 nm, with the average radius (on the basis of pore volume) being equal to 36 ± 7 nm [7] (Figs. 1a, 2).…”

Section: Characterization Of Sorbent Porous Structurementioning

confidence: 99%

“…1a, 2). Sorbent MMN200 is a polymer inorganic nanocomposite prepared by the method of chemical precipitation of magnetite nanoparticles having an average radius of 6.7 ± 3.8 nm into pores of Styrosorb 514 (wt % of Fe is 8.7-8.9%) [7] (Fig. 1b).…”

Section: Characterization Of Sorbent Porous Structurementioning

confidence: 99%

“…These problems may be solved to a large extent by the development of nanocomposite materials where a polymer hemocompatible matrix shields the surface of an inorganic component. The MMN200 composite material based on Styrosorb 514 and magnetite may be considered such a prospective material [7]. The purpose of this study was a comparative evalu ation of the capability of eliminating bacteria and fungi by two representatives of polymer sorbents based on hypercrosslinked styrene polymers (Styrosorb 514 and magnetic material MMN200 based thereon) and carbon hemosorbent used in medicinal practice.…”

Section: Prospects For the Application Of Biporous Sorbents Based On mentioning

confidence: 99%

“…In the overwhelming majority of cases, granular activated carbon (GAC) (for example, Adsorba 300C and Adsorba 150C, Gambro Co.; Hemocol, Sandev Co.) is used as a sorbent for hemosorption columns. Con temporary achievements in the field of development of porous synthetic materials resulted in a widening of the range of potential hemosorbents [5][6][7][8]. Due to their nanoporous structure and considerable adsorp tion activity [9], these sorbents are capable of bonding a wide range of biologically active molecules which act, among other things, as inflammatory mediators (bacterial endotoxin, cytokines, and hormones) [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prospects for the application of biporous sorbents based on hypercrosslinked styrene polymers for the prevention and treatment of systemic purulent-septic complications

et al. 2012

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to evaluate the capability of two sorbents based on hypercrosslinked styrene polymers (Styrosorb 514 and the magnetic material MMN200 based thereon) to adsorb bacteria and single cell fungi and compare it with the granular activated carbon (GAC) used in the hemoperfusion column Adsorba 300 (Gambro Co., Sweden). The sorbents under investigation based on polystyrene are distinguished by the presence of a large number of open micropores with diameters of 1.5-3 nm and macropores with diameters of up to 100 nm, resulting in a high specific surface area (806 m 2 /g for Styrosorb 514 and 580 m 2 /g for MMN200). The sorbents have been packed into miniature models of columns for perfusion through which suspensions of microorganisms B. subtilis, L. acidophilus, and S. cerevisiae in physiological saline were filtered. Perfusion through the columns depressed the colony formation of B. subtilis and L. acidophilus by 95% and 90% for Styrosorb 514 and 84% and 91% for the carbon, respectively. After perfusion through MMN200, the index of colony formation inhibition for both tested cultures was 21% (B. subtilis) and 25% (L. acidophilus). In addition, the investigated sorbents were found to exert a pronounced influence on S. cer evisiae yeast cells by reducing their amount in the suspension and decreasing the proportion of live cells in the remaining fraction when compared to intact controls (by 82% and 26% for Styrosorb 514, 74% and 27% for carbon, and 76% and 12% for MMN200, respectively). Thus, the results indicate that the biporous sorbents based on hypercrosslinked styrene polymers are distinguished by hemocompatibility and capable of eliminat ing different microorganisms, along with endogenous inflammation mediators and trigger factors provoking the development of organ and multiple organ failure. Therefore, the investigated sorbents can be effectively used for the treatment of patients with bacteriaemia, sepsis, and septic shock of different origins.

show abstract

Section: Characterization Of Sorbent Porous Structurementioning

confidence: 99%

Section: Characterization Of Sorbent Porous Structurementioning

confidence: 99%

Section: Prospects For the Application Of Biporous Sorbents Based On mentioning

confidence: 99%