Magnetic multicore nanoparticles for hyperthermia—influence of particle immobilization in tumour tissue on magnetic properties

Dutz, Silvio; Kettering, Melanie; Hilger, Ingrid; Müller, Robert N.; Zeisberger, Matthias

doi:10.1088/0957-4484/22/26/265102

Cited by 189 publications

(164 citation statements)

References 22 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…As has been noted previously, it is difficult to achieve the required tumor concentration by IV administration. 79 In our study, 1.7 g Fe/kg was used and delivered a sufficient amount to the tumor. Another striking difference between our study and others is that only a single heat treatment of 2 minutes duration was used, while all other studies utilized a treatment time of at least 20 minutes and some performed multiple treatments.…”

mentioning

confidence: 99%

Intravenous magnetic nanoparticle cancer hyperthermia

Huang¹,

Hainfeld²

2013

IJN

102

View full text Add to dashboard Cite

Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio . 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

show abstract

mentioning

confidence: 99%

Intravenous magnetic nanoparticle cancer hyperthermia

Huang¹,

Hainfeld²

2013

IJN

102

View full text Add to dashboard Cite

show abstract

“…The magnetic characterization of the removed tumor tissue confirmed that the particles are not able to rotate, and a temperature increase due to Brown relaxation can be nearly neglected [9]. The correct estimation of the heating potential of MNPs under "real" conditions will help in designing formulations with even better suitability for magnetic heating purposes.…”

Section: The Degree Of Immobilization Of Mnp In Tumors Determines Heamentioning

confidence: 97%

Means to increase the therapeutic efficiency of magnetic heating of tumors

Kettering

Grau

Pömpner

et al. 2015

Biomedical Engineering / Biomedizinische Technik

Self Cite

View full text Add to dashboard Cite

Abstract:The treatment of tumors via hyperthermia has gained increased attention in the last years. Among the different modalities available so far, magnetic hyperthermia has the particular advantage of offering the possibility of depositing the heating source directly into the tumor. In this study, we summarized the present knowledge we gained on how to improve the therapeutic efficiency of magnetic hyperthermia using magnetic nanoparticles (MNPs), with particular consideration of the intratumoral infiltration of the magnetic material. We found that (1) MNPs will be mainly immobilized at the tumor area and that this aspect has to be considered when estimating the heating potential of MNPs, (2) the intratumoral distribution patterns via slow infiltration might well be modulated by specific MNP coating and magnetic targeting, (3) imaging of the nanoparticle depositions within the tumor might allow to correct the distribution pattern via multiple applications, (4) multiple therapeutic sessions are feasible because MNPs are not delivered from the tumor site during the heating process, (5) the utilization of MNPs that internalize into cells will favor the production of intracellular heating spots rather than extracellular ones, (6) utilization of MNPs functionalized with chemotherapeutic agents will allow us to exploit the additive effects of both therapeutic modalities, and (7) distinct cytopathological and histopathological alterations in target tissues are induced as a result of magnetic hyperthermia. However, the accumulation at the tumor via intravenous application remains a matter of challenge.

show abstract

“…The immobilization state determines the relaxation behaviour of the administered particles and thus their specific heating power (Dutz et al, 2011). If the particles are not able to rotate and a temperature increase due to Brown relaxation can be neglected.…”

Section: Hyperthermia Treatmentmentioning

confidence: 99%

“…If the particles are not able to rotate and a temperature increase due to Brown relaxation can be neglected. An investigation showed that carboxymethyl dextran coated magnetic particles are fixed rather strongly to the tumor tissue after injection into a tumor (Dutz et al, 2011).…”

Section: Hyperthermia Treatmentmentioning

confidence: 99%