Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Bucak, Şeyda; Yavuztürk, Banu; Sezer, Ali Demir

doi:10.5772/52115

Cited by 42 publications

(29 citation statements)

References 143 publications

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“…Earlier nanotoxicity studies reported that many metal oxide NPs disturb redox systems and cause cell death in different cell lines (Hussain et al, ; Guo et al, ; Siddiqui et al, ). The nanosize and shape of Fe 3 O 4 NPs in the 50–100 nm range with high surface area and their aggregation or agglomeration are important physicochemical factors for modulating intracellular events because nanoscale materials easily interact with cell surfaces by aggregation or agglomeration factors, altering the metabolic processes of cells (Yamashita et al, ; Bucak et al, ). Different mean sizes of agglomerates of Fe 3 O 4 NPs (50–300 nm) easily interact with cells and disturb the properties of the redox system, leading to an inflammatory response and cell death (Athinarayanan et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Fe 3 O 4 was initially considered nontoxic because micro‐ and macrosize Fe 3 O 4 is naturally broken to discharge Fe ions, which is involved in iron metabolism. It has, however, been recognized that nano‐sized Fe 3 O 4 particles with large surface areas might pose an additional hazard as the particles can reach high local concentrations within cells and are generally more difficult to efficiently clear from the body (Bucak et al, ). In addition, the increasing usage and production of Fe 3 O 4 NPs results in risks for inevitable human and environmental exposure.…”

Section: Introductionmentioning

confidence: 99%

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Fe₃O₄ nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Periasamy

Athinarayanan

Alhazmi

et al. 2014

Environmental Toxicology

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The use of engineered nanoparticles (NPs) across multiple fields and applications has rapidly increased over the last decade owing to their unusual properties. However, there is an increased need in understanding their toxicological effect on human health. Particularly, iron oxide (Fe3 O4 ) have been used in various sectors, including biomedical, food, and agriculture, but the current understanding of their impact on human health is inadequate. In this investigation, we assessed the toxic effect of Fe3 O4 NPs on human mesenchymal stem cells (hMSCs) adopting cell viability, cellular morphological changes, mitochondrial transmembrane potential, and cell-cycle progression assessment methodologies. Furthermore, the expression of oxidative stress, cell death, and cell-cycle regulatory genes was assessed using quantitative polymerase chain reaction. The Fe3 O4 NPs induced cytotoxicity and nuclear morphological changes in hMSCs by dose and time exposure. Cell-cycle analysis indicated that Fe3 O4 NPs altered the cell-cycle progression through a decrease in the proportion of cells in the G0 -G1 phase. The hMSC mitochondrial membrane potential loss increased with an increase in the concentration of Fe3 O4 NPs exposure. The observed expression levels of the CYP1A, TNF3, TNFSF10, E2F1, and CCNC genes were significantly upregulated in hMSCs in response to Fe3 O4 NPs exposure. Our findings suggest that Fe3 O4 NPs caused metabolic stress through altered cell cycle, oxidative stress, and cell death regulatory gene expression in hMSCs. The results of this investigation revealed that Fe3 O4 NPs exhibited moderate toxicity on hMSCs and that Fe3 O4 NPs may have biomedical applications at low concentrations. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 901-912, 2016.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fe₃O₄ nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Periasamy

Athinarayanan

Alhazmi

et al. 2014

Environmental Toxicology

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“…Its second aim is the controlled release of the drug to avoid classical overdosing/underdosing cycle. [8,9] In addition, DDS protects the drug from rapid degradation or clearance and enhances drug concentration in target tissues, therefore, lower doses of drug are required. [10] Targeted drug delivery aims to reduce the undesired side effects of drug usage by directing or capturing the active agents near the desired site within the body.…”

Section: Drug Delivery and Targeting Systemsmentioning

confidence: 99%

“…When MNPs are embedded in chitosan to obtain magnetic chitosan particles, they have shown to exhibit relatively low cytotoxicity due to complete coverage of MNPs with chitosan. [8] The application of chitosan suffers severe limitations because of its poor solubility both in water and organic solvents due to its rigid crystalline structure. Limited solubility of chitosan in water and other organic solvents has prevented its full exploitation in drug delivery and tissue repair.…”

Section: Application Of Chitosan Mnps In Ddssmentioning

confidence: 99%

Chitosan magnetic nanoparticles for drug delivery systems

Assa

Jafarizadeh‐Malmiri

Ajamein

et al. 2016

Critical Reviews in Biotechnology

150

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The potential of magnetic nanoparticles (MNPs) in drug delivery systems (DDSs) is mainly related to its magnetic core and surface coating. These coatings can eliminate or minimize their aggregation under physiological conditions. Also, they can provide functional groups for bioconjugation to anticancer drugs and/or targeted ligands. Chitosan, as a derivative of chitin, is an attractive natural biopolymer from renewable resources with the presence of reactive amino and hydroxyl functional groups in its structure. Chitosan nanoparticles (NPs), due to their huge surface to volume ratio as compared to the chitosan in its bulk form, have outstanding physico-chemical, antimicrobial and biological properties. These unique properties make chitosan NPs a promising biopolymer for the application of DDSs. In this review, the current state and challenges for the application magnetic chitosan NPs in drug delivery systems were investigated. The present review also revisits the limitations and commercial impediments to provide insight for future works.

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“…From this point of view magnetic nanostructures (NSs) are promising as a tool for prevention, diagnostics, and treatment of a wide range of diseases [1]. Control of shape, sizes, and chemical composition of NSs allows setting their physical properties at synthesis stage that opens a lot of opportunities for bioapplications, such as hyperthermia, cell separation [2], and biosensorics, as contrast substance in magnetic and sonoluminescence tomography [3,4].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

Kozlovskiy

Korolkov

Kalkabay

et al. 2017

Journal of Nanomaterials

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Due to the Ni nanotubes' shape anisotropy, low specific density, large specific surface, and uniform magnetic field, they have been offered as carriers for targeted delivery of drug or protein and the process of their formation from synthesis stage to the stage of surface modification and protein attaching has been demonstrated. Some steps to hasten their biomedical application have been applied. First, to have full control over the carrier dimensions and structure parameters, electrodeposition method in pores of polyethylene terephthalate template has been applied. Second, to understand the scope of Ni nanostructures application, their degradation in media with different acidity has been studied. Third, to improve the biocompatibility and to make payloads attachment possible, nanotubes surface modification with organosilicon compound has been carried out. At last, the scheme of protein attaching to the nanostructure surface has been developed and the binding process was demonstrated as an example of the bovine serum albumin.

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Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Cited by 42 publications

References 143 publications

Fe₃O₄ nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Fe₃O₄ nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Chitosan magnetic nanoparticles for drug delivery systems

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

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Magnetic Nanoparticles: Synthesis, Surface Modifications and Application in Drug Delivery

Cited by 42 publications

References 143 publications

Fe3O4 nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Fe3O4 nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Chitosan magnetic nanoparticles for drug delivery systems

Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

Contact Info

Product

Resources

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Fe₃O₄ nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells

Fe₃O₄ nanoparticle redox system modulation via cell‐cycle progression and gene expression in human mesenchymal stem cells