Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Abstract

The aim of this study is a present of a simple solvothermal synthesis approach to preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF were fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality, desirable magnetic property and also high specific surface area. Different influential factors on extraction recovery including sorbent dosage, ultrasonic time, washing solvent volume and eluent solvent volume were assessed using central composite design (CCD) based response surface methodology (RSM) as an operative and powerful optimization tool. This is the first report for determination of AMP using MMOF. The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP. The presented method decreases the extraction time (4 min) and also enhances adsorption capacity (250 mg/g). Moreover, the magnetic property of presented sorbent (15 emu/g) accelerates the extraction process which does not need filtration, centrifuge and precipitation procedures. Under the optimized conditions, the proposed method is applicable for linear range of 1.0–5000.0 μg/L with detection limit of 0.29 μg/L, satisfactory recoveries (≥95.0%) and acceptable repeatability (RSD less than 4.0%). The present study indicates highly promising perspectives of MMOF for highly effective analysis of AMP in complicated matrices.

Functional Hybrid Micro/Nanoentities Promote Agro-Food Safety Inspection

“…Recently, most researchers combine MOF with functional nano- and microparticles to prepare porous nanocomposites. , Such materials had the functions of nanomaterials while retaining the special structure and properties of MOFs, thus expanding the application scope of MOF materials . In particular, the combination of magnetic nanoparticles and MOFs to form magnetic MOF (MMOF) materials has attracted great interest from researchers by the feature of localization or collection by an external magnetic field . The combination of MOF material and magnetic nanoparticles has the following advantages: − (1) The target ability of MMOF material application was enhanced.…”

“…86 In particular, the combination of magnetic nanoparticles and MOFs to form magnetic MOF (MMOF) materials has attracted great interest from researchers by the feature of localization or collection by an external magnetic field. 87 The combination of MOF material and magnetic nanoparticles has the following advantages: 88−91 (1) The target ability of MMOF material application was enhanced. By selection of suitable target substances and regulation of the synthesis conditions, MMOF materials could be constructed for specific applications (e.g., catalysis, adsorption, and release).…”

Synthesis of Magnetic Metal-Organic Frame Material and Its Application in Food Sample Preparation

“…The deposition and hydrophobic interaction between Fe3O4-NH2@MOF-235 and the analyte plays an important role in the adsorption process, and the maximum adsorption capacity can be reached Up to now, more and more studies on the development and application of MMOFs for analyzing pesticide and veterinary drug residues were reported. The detection targets also extended to fluoroquinolones [141,142], sulfonamides [143], ampicillin [144], nitroimidazoles [145], benzoylurea insecticides [146], tetracycline [147], triazine herbicides [148] et al, Duo et al, synthesized a novel, spinel-like magnetic metal-organic skeleton material (Fe 3 O 4 -NH 2 @MOF-235) by a two-step solvothermal method, and used as SPE adsorbent for simultaneous extraction and determination of five benzoyl urea pesticides in honey, fruit juice and tap water samples [149]. The deposition and hydrophobic interaction between Fe 3 O 4 -NH 2 @MOF-235 and the analyte plays an important role in the adsorption process, and the maximum adsorption capacity can be reached within 5 min.…”

Recent Applications of Magnetic Nanoparticles in Food Analysis

“…Table 2 shows a selection of recent applications of m-MOFs to the food analysis field [33][34][35][36][37][38][39][40][41][42]. The works reported describe the extraction of both organic [33,34,[36][37][38][41][42][43] and inorganic [39,40] compounds in a wide variety of matrices.…”