Magnetic and radio-labeled bio-hybrid scaffolds to promote and track <i>in vivo</i> the progress of bone regeneration

Campodoni, Elisabetta; Vélez, Marisela; Fragogeorgi, Eirini; Morales, Irene García; Presa, Patricia de la; Stanicki, Dimitri; Dozio, Samuele M.; Xanthopoulos, Stavros; Bouziotis, Penelope; Dermisiadou, Eleftheria; Rouchota, Maritina; Loudos, George; Marı́n, P.; Laurent, Sophie; Boutry, Sébastien; Panseri, Silvia; Montesi, Monica; Tampieri, Anna; Sandri, Monica

doi:10.1039/d1bm00858g

Cited by 13 publications

(8 citation statements)

References 41 publications

(62 reference statements)

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“…For example, dopamine‐Fe (III) chelating nanoparticles were applied to monitor the state of implanted hydrogels and newborn cartilage in a real‐time and non‐invasive manner [159] . Furthermore, CT and MRI are employed jointly in the instance where commercial radiolabel ([99mTc] Tc‐MDP) was utilized to demonstrate metabolic activity and visualize fresh bone generation with exceptional precision, while superparamagnetic iron oxide nanoparticles administered at a specific dosage were implemented for echo SPECT/CT and MRI [160] . Figure 10a shows SPECT/CT obtained up to 5 weeks after surgery, demonstrating that the metabolic activity climbed to a maximum on day 7 and did not show any remarkable changes until day 20.…”

Section: Imaging Systems For Bone Regenerationmentioning

confidence: 99%

“…The 1st row: CT images on the skull of a Swiss Albino mouse model; and the 2nd row: fused SPECT/CT images at 3 h post‐injection with the bone imaging tracer [ 99m Tc] Tc‐MDP (ca. 2 mCi) [160] . Copyright 2021, Royal Society of Chemistry.…”

Section: Imaging Systems For Bone Regenerationmentioning

confidence: 99%

“…[159] Furthermore, CT and MRI are employed jointly in the instance where commercial radiolabel ([99mTc] Tc-MDP) was utilized to demonstrate metabolic activity and visualize fresh bone generation with exceptional precision, while superparamagnetic iron oxide nanoparticles administered at a specific dosage were implemented for echo SPECT/CT and MRI. [160] Figure 10a shows SPECT/CT obtained up to 5 weeks after surgery, demonstrating that the metabolic activity climbed to a maximum on day 7 and did not show any remarkable changes until day 20. Besides, barium-containing compounds were also selected to facilitate X-ray imaging ability because of their strong shielding effects.…”

Section: Regenerationmentioning

confidence: 99%

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Advanced strategies of scaffolds design for bone regeneration

Song,

Li,

Fang

et al. 2023

BMEMat

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Bone defects are encountered substantially in clinical practice, and bionic scaffolds represent a promising solution for repairing bone defects. However, it is difficult to fabricate scaffolds with bionic structures and reconstruct the microenvironment to fulfill the satisfying repair effects. In this review article, we first discuss various strategies for the design and construction of bionic scaffolds to promote bone defect repair, especially including the structural construction of the scaffold and the integration of bioactive substances together with the application of external stimuli. We then discuss the roles of artificial intelligence and medical imaging in aiding clinical treatment. Finally, we point out the challenges and future outlooks in developing multifunctional bone repair scaffolds, aiming to provide insights for improving bone regeneration efficacy and accelerating clinical translation.

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Section: Imaging Systems For Bone Regenerationmentioning

confidence: 99%

Section: Imaging Systems For Bone Regenerationmentioning

confidence: 99%

Section: Regenerationmentioning

confidence: 99%

See 1 more Smart Citation

Advanced strategies of scaffolds design for bone regeneration

Song,

Li,

Fang

et al. 2023

BMEMat

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“…[94]. Campodoni et al [95] combined two magnetic NPs with a bone-repair scaffold to trace the process of bone regeneration in vivo. Radioactive tracers that were analysed and evaluated using SPECT/CT techniques showed that 0.75 wt% magnetic NPs mixed into bone scaffolds was sufficient to label bone tissues with magnetic NPs and monitor bone regeneration in vivo.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

et al. 2023

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Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone injury repair. First, an overview of the hierarchical architecture from the macroscale to the nanoscale of natural bone is presented, as these bone tissue microstructures and compositions are the basis for constructing bone substitutes. Next, urgent clinical issues associated with bone injury that require resolution and the potential of nanomaterials to overcome them are discussed. Finally, nanomaterials are classified as inorganic or organic based on their chemical properties. Their basic characteristics and the results of related bone engineering studies are described. This review describes theoretical and technical bases for the development of innovative methods for repairing damaged bone and should inspire therapeutic strategies with potential for clinical applications.

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“…For example, diagnostic markers can significantly improve the localization of biohybrid systems, as demonstrated by the CT imaging of biohybrid scaffold materials labeled with gold [85] and barium nanoparticles, [86] and MRI with manganese-loaded porphyrins, [87] ferritin derivatives, [88] and SPIONs. [46,89] Furthermore, 19 F-containing markers are often used for MRI labeling because fluorine is not usually found at significant concentrations in human soft tissues. Examples include fluorinated hydrogels [90] and vascular biohybrid scaffolds constructed from thermoplastic polyurethane and visualized by hybrid 1 H/ 19 F MRI.…”

Section: Noninvasive Imagingmentioning

confidence: 99%

Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology

Fernández‐Colino

Kießling

Slabu

et al. 2023

Adv Healthcare Materials

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Today's living world is enriched with a myriad of natural biological designs, shaped by billions of years of evolution. Unraveling the construction rules of living organisms offers the potential to create new materials and systems for biomedicine. From the close examination of living organisms, several concepts emerge: hierarchy, pattern repetition, adaptation, and irreducible complexity. All these aspects must be tackled to develop transformative materials with lifelike behavior. This perspective article highlights recent progress in the development of transformative biohybrid systems for applications in the fields of tissue regeneration and biomedicine. Advances in computational simulations and data‐driven predictions are also discussed. These tools enable the virtual high‐throughput screening of implant design and performance before committing to fabrication, thus reducing the development time and cost of biomimetic and biohybrid constructs. The ongoing progress of imaging methods also constitutes an essential part of this matter in order to validate the computation models and enable longitudinal monitoring. Finally, the current challenges of lifelike biohybrid materials, including reproducibility, ethical considerations, and translation, are discussed. Advances in the development of lifelike materials will open new biomedical horizons, where perhaps what is currently envisioned as science fiction will become a science‐driven reality in the future.

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Magnetic and radio-labeled bio-hybrid scaffolds to promote and track in vivo the progress of bone regeneration

Abstract: This work describes the preparation, characterization and functionalization with magnetic nanoparticles of a bone tissue-mimetic scaffold composed of collagen and hydroxyapatite obtained thorough a biomineralization process. Bone remodeling takes place...

Cited by 13 publications

References 41 publications

Advanced strategies of scaffolds design for bone regeneration

Advanced strategies of scaffolds design for bone regeneration

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology

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