Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Wan, Teng; Zhang, Meng; Jiang, H.; Zhang, Yi-Chong; Zhang, Xiaomeng; Wang, Yi-Lin; Zhang, Peixun

doi:10.3390/nano13091449

Cited by 3 publications

(2 citation statements)

References 125 publications

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“…Numerous natural and artificial nanostructured compounds have been investigated for the management of bone deformities ( Wan et al, 2023 ; Wen et al, 2023 ). Natural biomaterials have the benefit of being highly biocompatible, however, the way they handle features and support from structures is inadequate.…”

Section: Epidemiology: Keeping Orthopaedic Disorders In Perspectivementioning

confidence: 99%

Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices

Liang,

Zhou,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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A developing use of nanotechnology in medicine involves using nanoparticles to administer drugs, genes, biologicals, or other materials to targeted cell types, such as cancer cells. In healthcare, nanotechnology has brought about revolutionary changes in the treatment of various medical and surgical conditions, including in orthopedic. Its clinical applications in surgery range from developing surgical instruments and suture materials to enhancing imaging techniques, targeted drug delivery, visualization methods, and wound healing procedures. Notably, nanotechnology plays a significant role in preventing, diagnosing, and treating orthopedic disorders, which is crucial for patients’ functional rehabilitation. The integration of nanotechnology improves standards of patient care, fuels research endeavors, facilitates clinical trials, and eventually improves the patient’s quality of life. Looking ahead, nanotechnology holds promise for achieving sustained success in numerous surgical disciplines, including orthopedic surgery, in the years to come. This review aims to focus on the application of nanotechnology in orthopedic surgery, highlighting the recent development and future perspective to bridge the bridge for clinical translation.

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Section: Epidemiology: Keeping Orthopaedic Disorders In Perspectivementioning

confidence: 99%

Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices

Liang,

Zhou,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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“…2 Because bone possesses a certain degree of self-healing ability, bone defects smaller than the critical size defect (CSD) can spontaneously heal. 3 However, in most cases, bone defects exceed the critical size and cannot heal naturally, necessitating artificial treatment methods.…”

Section: Introductionmentioning

confidence: 99%

Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering

Xu,

Wang,

Huang

et al. 2024

Biomater. Sci.

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Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Mohammadzadeh,

Zarei,

Abbasi

et al. 2024

J Biol Eng

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There is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of bone regeneration involves the transformation of mesenchymal stromal cells into osteoblasts and the subsequent mineralization of the extracellular matrix, making up the complex mechanism of osteogenesis. Icariin’s diverse pharmacological properties, such as anti-inflammatory, anti-oxidant, and osteogenic effects, have attracted considerable attention in biomedical research. Icariin, known for its ability to stimulate bone formation, has been found to encourage the transformation of mesenchymal stromal cells into osteoblasts and improve the subsequent process of mineralization. Several studies have demonstrated the osteogenic effects of icariin, which can be attributed to its hormone-like function. It has been found to induce the expression of BMP-2 and BMP-4 mRNAs in osteoblasts and significantly upregulate Osx at low doses. Additionally, icariin promotes bone formation by stimulating the expression of pre-osteoblastic genes like Osx, RUNX2, and collagen type I. However, icariin needs to be effectively delivered to bone to perform such promising functions.Encapsulating icariin within nanoplatforms holds significant promise for promoting osteogenesis and bone regeneration through a range of intricate biological effects. When encapsulated in nanofibers or nanoparticles, icariin exerts its effects directly at the cellular level. Recalling that inflammation is a critical factor influencing bone regeneration, icariin's anti-inflammatory effects can be harnessed and amplified when encapsulated in nanoplatforms. Also, while cell adhesion and cell migration are pivotal stages of tissue regeneration, icariin-loaded nanoplatforms contribute to these processes by providing a supportive matrix for cellular attachment and movement. This review comprehensively discusses icariin-loaded nanoplatforms used for bone regeneration and osteogenesis, further presenting where the field needs to go before icariin can be used clinically.

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Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Cited by 3 publications

References 125 publications

Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices

Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices

Efforts to promote osteogenesis–angiogenesis coupling for bone tissue engineering

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

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