Magnesium, zinc, and chromium levels in children, adolescents, and young adults with type 1 diabetes

Lin, Ching‐Chiang; Tsweng, G.-J.; Lee, Cheng-Fa; Chen, Bai-Hsiun; Huang, Yeou‐Lih

doi:10.1016/j.clnu.2015.05.022

Cited by 39 publications

(32 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with Mishra et al [35] where they found a positive correlation between age of T2DM adults and serum magnesium level ( r = 0.721) ( P < 0.001) but disagreed with Lin et al [21] and Salmonowicz et al [22] who showed no correlation between age of T1DM children and serum magnesium level. This disagreement could be explained by different study populations between their studies and ours.…”

Section: Discussionsupporting

confidence: 87%

“…Inconsistent with our result, Lin et al [21] and Salmonowicz et al [22] did not show any correlation between serum magnesium level and HbA1c in type 1 diabetic children and adolescents. Also, Matthiesen et al [28] did not observe any relationship between HbA1c and ionized magnesium and Wegner et al [33] failed to show any relation between serum magnesium and diabetic controls in the form of Fasting Blood Glucose.…”

Section: Discussionsupporting

confidence: 75%

“…This disagreement could be explained by different study populations between their studies and ours. Wang et al [34] showed similar results to Lin et al [21] and Salmonowicz et al [22] but in type 2 diabetes patients. Jiancheng et al [20] stated that in adults with T2DM; older age is seen more frequent among the normomagnesemic group.…”

Section: Discussionsupporting

confidence: 61%

“…These results are in concordance with Jiancheng et al [20] on 25 children with type I diabetes from Northeast area of China that revealed a lower serum magnesium level in type I diabetic children compared to control subjects. Lin et al, [21] Salmonowicz et al, [22] and Bjelakovic et al [23] showed also similar results in type 1 diabetic children and adolescents compared to healthy controls. Indeed Fort and Lifshitz [24] and Tuvemo et al [25] have found a lower serum total magnesium in type 1 diabetic children especially those with poor glycemic control when compared to their healthy age- and sex-matched control Also, our results are concordant with Seyoum et al [26] that found a higher percentage of hypomagnesemia (65%) among adults with type I and type II diabetes compared to control group and that is considered higher than that the percentage in our study.…”

Section: Discussionmentioning

confidence: 72%

“…This is consistent with a study on adults with T2DM by Mishra et al [35] that showed a negative correlation between the serum magnesium level and duration of diabetes ( r = −0.789). However, Lin et al [21,] Salmonowicz et al [22] and Sjogren et al [38] failed to show any relation between duration of diabetes and serum magnesium level in type I diabetic children. This difference may be due to different study populations and variable degree of diabetic control among these populations.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile

Shahbah

Naga²,

Hassan³

et al. 2016

Medicine

View full text Add to dashboard Cite

Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency, having 25% to 39% prevalence. This deficit could be associated with the development of late diabetic complications, especially macroangiopathy.We aimed to evaluate the status of serum Mg in children with type 1 diabetes and assess its relation to glycemic control and lipid profile.We included 71 Egyptian children with type 1diabetes having their follow-up at Pediatric Endocrinology outpatient clinic, Zagazig University Hospital and 71 age- and sex-matched control. We measured Serum magnesium, HbA1c, and lipid profile in all study subjects.Diabetic children had significantly lower serum magnesium level compared to control children (1.83 ± .27 mg/dL in diabetic children versus 2.00 ± .16 mg/dL in control children). Taking cut-off level of serum magnesium <1.7 mg/dL for definition of hypomagnesemia, hypomagnesemia was detected in 28.2% of diabetic children compared to 9.9% of control children. In diabetic patients, there was statistically significant difference in HbA1c between hypomagnesemic and normomagnesemic group being higher in the low magnesium group, as it is mean ± SD was 11.93 ± 3.17 mg/dL in group I versus 8.92 ± 0.93 mg/dL in the normomagnesemic group. Serum magnesium was found to be positively correlated with HDL (P < 0.001), and negatively correlated with age, HbA1c, triglycerides, total cholesterol, LDL, and duration of diabetes (P < 0.001).We concluded that total serum magnesium was frequently low in Egyptian children with type 1 diabetes and it is correlated with HbA1c and with lipid profile. Hypomagnesemia was more evident in patients with poor diabetic control and those with higher atherogenic lipid parameters. We suggest that low serum magnesium may be included in pathogenesis of poor glycemic control and abnormal lipid profile in children with type 1 diabetes. We need to perform further studies on giving magnesium supplements in diabetic children with hypomagnesemia to observe the effect of correction of serum magnesium on glycemic control, lipid profile, and the risk of diabetic complications.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile

Shahbah

Naga²,

Hassan³

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

Body composition helps to elucidate the different origins of low serum magnesium in children with obesity compared to children with type 1 diabetes

Van Eyck,

Ledeganck,

Vermeiren

et al. 2023

Eur J Pediatr

View full text Add to dashboard Cite

Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes

et al. 2019

View full text Add to dashboard Cite

Glycemia and insulin resistance are important regulators of multiple physiological processes and their dysregulation has wide-ranging consequences, including alterations in plasma concentrations of metal micronutrients. Here, magnesium, zinc, copper, selenium and glycated albumin (HbA1c) concentrations and quartile differences were examined in 45 subjects with type-I diabetes (T1DM), 54 subjects with type-II diabetes (T2DM) and 62 control subjects in order to assess potential differences between sexes and between T1DM and T2DM. Plasma magnesium concentration was decreased in T1DM subjects, with the second, third and fourth quartiles of magnesium concentrations associated with the absence of T1DM. This effect was observed in females but not males. In T2DM, the highest quartile of selenium concentrations and the third quartile of copper concentrations associated with the absence of diabetes in males. The highest quartile of magnesium concentrations was associated with the absence of T2DM in males but not females. HbA1c correlated with plasma concentrations of magnesium (negatively, in both sexes together in T1DM and T1DM males), copper (positively, in T1DM males and in both sexes together in T2DM), selenium (positively, in both sexes together in T1DM and T2DM, and T2DM females) and with zinc/copper ratio (negatively, in both sexes together in T1DM and T2DM). This study shows that plasma magnesium concentration is altered to the highest degree in T1DM, while in T2DM, plasma selenium and copper concentrations are significantly affected. This work increases our understanding of how T1DM and T2DM affects plasma metal concentrations and may have future implications for diabetes management.

show abstract

Magnesium, zinc, and chromium levels in children, adolescents, and young adults with type 1 diabetes

Cited by 39 publications

References 24 publications

Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile

Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile

Body composition helps to elucidate the different origins of low serum magnesium in children with obesity compared to children with type 1 diabetes

Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes

Contact Info

Product

Resources

About