Body composition helps to elucidate the different origins of low serum magnesium in children with obesity compared to children with type 1 diabetes

Van Eyck, Annelies; Ledeganck, Kristien J.; Vermeiren, Eline; De Lamper, Astrid; Eysackers, Marie; Mortier, Julie; Van Vliet, Marinus P.; Broere, Petrus; Roebersen, Melvin; France, Annick; Dotremont, Hilde; Van Hoorenbeeck, Kim; Verhulst, Stijn L.; den Brinker, Marieke; Trouet, Dominique

doi:10.1007/s00431-023-05046-5

Cited by 6 publications

(2 citation statements)

References 47 publications

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“…Bioimpedance devices use a whole-body bioimpedance spectroscopy technique, which is commonly used for the evaluation of body composition, total body fluid volume, intracellular volume, and extracellular volume, both in adults and children [4][5][6]. The bioimpedance spectroscopy is already currently widely used in various nephrological settings to calculate fluid overload and determine patient's optimal fluid status [7][8][9][10] and its use for the assessment of fluid status in healthy children has already been successfully validated [11].…”

Section: Introductionmentioning

confidence: 99%

Fluids and body composition during anesthesia in children and adolescents: A pilot study

Betti,

Busi,

Cortesi

et al. 2024

Eur J Pediatr

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The purpose of this study is to evaluate the intracellular and extracellular volume before and after anesthesia in order to ascertain their variations and determine the potential utility of this information in optimizing intraoperative fluid administration practices. A bioimpedance spectroscopy device (body composition monitor, BCM) was used to measure total body fluid volume, extracellular volume, and intracellular volume. BCM measurements were performed before and after general anesthesia in unselected healthy children and adolescents visiting the Pediatric Institute of Southern Switzerland for low-risk surgical procedures hydrated with an isotonic solution. In 100 children and adolescents aged 7.0 (4.8–11) years (median and interquartile range), the average total body water increased perioperatively with a delta value of 182 (0–383) mL/m2 from pre- to postoperatively, as well as the extracellular water content, which had a similar increase with a delta value of 169 (19–307) mL/m2. The changes in total body water and extracellular water content significantly correlated with the amount of fluids administered. The intracellular water content did not significantly change. Conclusion: Intraoperative administration of isotonic solutions results in a significant fluid accumulation in low-risk schoolchildren during general anesthesia. The results suggest that children without major health problems undergoing short procedures do not need any perioperative intravenous fluid therapy, because they are allowed to take clear fluids up to 1 h prior anesthesia. In future studies, the use of BCM measurements has the potential to be valuable in guiding intraoperative fluid therapy. What is Known:• Most children who undergo common surgical interventions or investigations requiring anesthesia are nowadays hydrated at a rate of 1700 mL/m2/day with an isotonic solution.• The use bioimpedance spectroscopy for the assessment of fluid status in healthy children has already been successfully validated.• The bioimpedance spectroscopy is already currently widely used in various nephrological settings to calculate fluid overload and determine patient’s optimal fluid status. What is New:• Routine intraoperative fluid administration results in a significant fluid accumulation during general anesthesia in low-risk surgical procedures.• This observation might be relevant for children and adolescents with conditions predisposing to fluid retention.• In future studies, the use of BCM measurements has the potential to be valuable in guiding intraoperative fluid therapy.

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Section: Introductionmentioning

confidence: 99%

Fluids and body composition during anesthesia in children and adolescents: A pilot study

Betti,

Busi,

Cortesi

et al. 2024

Eur J Pediatr

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“…Therefore, assessing the distribution of lean mass and adipose tissue is essential to help control blood glucose and prevent future complications in DM1 patients [ 27 ]. Given the above, this study aimed to investigate the relationship between body fat and lean mass distribution on HbA1c, lipid profile, and Apo A-I/B values in children with DM1.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

Menegucci,

Chagas,

de Oliveira Zanuso

et al. 2023

Diseases

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Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be associated with complications and HbA1c. This cross-sectional observational study of 81 children and adolescents of both sexes diagnosed with DM1 investigated the relationship between body fat distribution and lean mass with HbA1C and apolipoprotein values, analyzing biochemical and body composition measurements. A Shapiro–Wilk test with Lilliefors correction, a non-parametric Mann–Whitney test, and others were used with a significance level of 5%. The sample had a diagnosis time of 4.32 years and high blood glucose levels (mean 178.19 mg/dL) and HbA1c (mean 8.57%). Subjects also had a moderate level of adiposity, as indicated by arm and thigh fat areas. The study also found significant differences in the distribution of patients concerning levels of apolipoproteins A and B, with a smaller proportion of patients having undesirable levels. Finally, the study found a significant difference in the distribution of patients with estimated cardiovascular risk based on the ApoB/ApoA-I ratio. Conclusively, visceral fat in children and adolescents with DM1 may increase the risk of DM1 long-term complications owing to its association with elevated HbA1C and apolipoprotein values.

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Brain of miyoshi myopathy/dysferlinopathy patients presents with structural and metabolic anomalies

Hnilicova,

Grendar,

Turcanova Koprusakova

et al. 2024

Sci Rep

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Body composition helps to elucidate the different origins of low serum magnesium in children with obesity compared to children with type 1 diabetes

Cited by 6 publications

References 47 publications

Fluids and body composition during anesthesia in children and adolescents: A pilot study

Fluids and body composition during anesthesia in children and adolescents: A pilot study

The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

Brain of miyoshi myopathy/dysferlinopathy patients presents with structural and metabolic anomalies

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