Magnesium and chronic fatigue

Gantz, NelsonM.

doi:10.1016/0140-6736(91)90068-z

Cited by 9 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That brief paper evokcd several letters to the cditor (42)(43)(44)(45)(46)(47)(48). Two suggested that the favordble effect of Mg in muscle fatiguc might be a conscquence of thc role of Mg i n energy tnctabolism in the mitochondria (42,43); one wondercd how such a small amount of Mg could be bcncfi-cia1 (44); one pointed out liniitations of labomtory Mg detenninations (45) and several failed to confirm low rbc Mg findings in CFS patients (8), or in eithcr CFS or FM (45)(46)(47)(48). To cvaluate the role of Mg in CFS or Mg there was need for morc extcnsivc studies, of longcr duration (49).…”

Section: Reviewmentioning

confidence: 99%

Review and Hypothesis

Seelig

1998

Journal of Chronic Fatigue Syndrome

View full text Add to dashboard Cite

The latent tctany syndrome (LTS) parallels CFS in its neuro~nuscular and psychiatric manifestations, as well a s in inncr car disturbances: vestibular in CFS and FM, a s well as in LTS, and incrcascd vulnerability to noisc-induccd dcafncss in LTS. Microvas-Mildrcd Scclig is Adjunct Professor of Nutrition, Appreciation is cxpresscd to Harry Prcuss for suggesting that the author consider the possibility that magnesium deficiency might be a contributory factor in thc pa~hogcncsis of chronic fatiguc syndro~ne for a joint session of the ACN and the AACFS, Octobcr, 1996, and to Kay Franz for undc~.taking ;I litcrature search for her on CFS m d rcl;~tcd tlisortlcss.Journal of Chronic Fatigue Syndrome Downloaded from informahealthcare.com by Nanyang Technological University on 08/26/15For personal use only. JOURNAJd OF CHRONIC FATIGUE SWDROMEcular damage to the cochlea is seen in Mg deficiency, noisc-induccd deafness, and might be a factor in migraine and other severe headaches in both LTS and in CFS and FM. Abnormal sleep patterns occur in both LTS and CFS; impaired cognition more in CFS than in LTS. However, some brain and neurotransmitter dysfunctions seen with Mg dcficiency might be contributory to cognitive disorders of CFS. Mg loss caused by enhanced catecholamine release produced by stress may well be contributory to strcss-induced acute episodes of CFS. Malfunctions of the cellular and humoral immunological systems are caused by experimental Mg dcficiency. Whether allergies in CFS patients and abnormal response to antigenic challenge are results of low Mg remains to be provcn. Mitral valvc prolapse is secn in many LTS and CFS paticnts; whether a putative Mg deficiency predisposes to this abnormality is not known. Clinical improvement with Mg treatment has been proven in LTS, and seemed helpful in the rare cases of CFS and FM in whom it has been tricd. Thc Mg status should be determined in paticnt with CFS and FM, but methodology is a handicap. Serum Mg is an inaccurate index. Three methods show promise. Pcrccntagc retention of a Mg load is accurate but requires patient's coopcration. Free ionic Mg measurement requires ion-selective electrodes. Blood cell Mg is reliable in a littlc more than half the patients; sublingual ccll Mg sccms morc accuratc. Morc intcnsive, and controlled studies of the Mg status of CFS and FM patients, and of their response to Mg therapy is desirable. [Article copies availrrble for a feejonr The Howorth Docunrent Delrvery Service: 1-800-342-9678. E-nmil nddrrss: ge~info@hawo~hpr~ssinc.conr/

show abstract

Section: Reviewmentioning

confidence: 99%

Review and Hypothesis

Seelig

1998

Journal of Chronic Fatigue Syndrome

View full text Add to dashboard Cite

show abstract

“…Chronic fatigue is a heterogeneous syndrome with no clear cut causality and no consistent pathognomonic markers [16,17]. In the more well-defined subgroup of these patients, diagnosed as having Chronic Fatigue Syndrome (CFS) [18], the involvement of Mg in the pathogenesis remains controversial [14,19,20,21]. However, in patients with chronic fatigue in general and with CFS in particular, Mg supplementation has been empirically shown to be beneficial [14,22].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Status and Parameters of the Oxidant-Antioxidant Balance in Patients with Chronic Fatigue: Effects of Supplementation with Magnesium

Keenoy

Moorkens

Vertommen³

et al. 2000

Journal of the American College of Nutrition

View full text Add to dashboard Cite

show abstract

Characteristics of chronic fatigue syndrome in a Japanese community population

et al. 2011

View full text Add to dashboard Cite

This study seeks to estimate the prevalence of chronic fatigue syndrome (CFS) and assess the characteristics of CFS in a community population in Japan using laboratory tests and questionnaires for lifestyle, fatigue states, and depression states. The design of this study is a cross-sectional observational study. The setting of this study is a medical health checkup program in a general hospital. This study was conducted with 1,430 Japanese (867 men and 563 women), 20 to 78 years of age. We classified participants who complained of fatigue according to the case definition of CFS proposed by the Centers for Disease Control and Prevention in the USA in 1994. Alcohol, caffeine, catechin and total polyphenol consumption, smoking status, sleep duration, and physical activity were evaluated using questionnaires. The prevalence of CFS was 1.0% (95% CI 0.5-1.6%) of a community population in Japan. Although various lifestyle factors of the participants with CFS were similar to those without chronic fatigue, average sleep duration was significantly shorter among the participants with CFS (5.5 ± 0.8 h) compared to those without chronic fatigue (6.3 ± 0.9 h, P < 0.001). Proportion at subjects having average sleep duration of less than 6 h was 64.3% among the participants with CFS in contrast to only 15.0% in those without chronic fatigue (P < 0.001). Among the eight case-defining symptoms, "Unrefreshing sleep" had high sensitivity and high specificity for screening CFS in Japanese population (92.9% and 87.8%, respectively). The average sleep duration was notably shorter in Japanese suffering from CFS. Further longitudinal study is needed to evaluate the possibility of extreme short sleep duration as a major cause of CFS in Japan.

show abstract

Magnesium and chronic fatigue

Cited by 9 publications

References 1 publication

Review and Hypothesis

Review and Hypothesis

Magnesium Status and Parameters of the Oxidant-Antioxidant Balance in Patients with Chronic Fatigue: Effects of Supplementation with Magnesium

Characteristics of chronic fatigue syndrome in a Japanese community population

Contact Info

Product

Resources

About