Magnesium Status and Parameters of the Oxidant-Antioxidant Balance in Patients with Chronic Fatigue: Effects of Supplementation with Magnesium

Keenoy, B. Manuel y; Moorkens, Greta; Vertommen, J.; M, Noe; Nève, Jean; Leeuw, I. De

doi:10.1080/07315724.2000.10718934

Cited by 77 publications

(23 citation statements)

References 42 publications

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“…It is apparent that elevated circulating levels of neutrophils and lymphocytes contribute to both the acute and chronic phases of the inflammatory responses in the Mg-deficient rats [30], and CRP was elevated in obese subjects [31]. Furthermore, it has even been proposed that there is a causal link between magnesium deficiency, oxidative stress, and the inflammatory state [32][33][34]. Cellular magnesium, which is competitive with calcium, shows opposite effects on insulin sensitivity contrarily.…”

Section: Discussionmentioning

confidence: 94%

Hair Tissue Mineral Analysis and Metabolic Syndrome

Park

Choi

Nam

2009

Biol Trace Elem Res

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Deficiency of minerals causes functional abnormality of enzymes, frequently resulting in metabolic disturbance. We investigated possible relationship between minerals and metabolic syndrome by analysis of hair tissue minerals. We selected 848 subjects older than 20 years of age at Ajou University Hospital from May 2004 to February 2007. We excluded the subjects who had cancers, steroid and thyroid medication, and incomplete record from the study. Finally, 343 subjects were eligible. We performed cross-sectional analysis for the relationship between minerals and metabolic syndrome. The contents of calcium, magnesium, and copper in the metabolic syndrome group were significantly lower than those of the normal group, whereas the amounts of sodium, potassium, and mercury in the metabolic syndrome group were significantly higher than those of the normal group. By dividing the subjects into quartile with the level of calcium, magnesium, and mercury concentrations, we carried out logistic regression analysis to study the subjects and found that the subjects in the third quartile of calcium and magnesium concentrations had significantly lower odds ratio (OR) of the metabolic syndrome compared with that of the lowest quartile group [OR = 0.30, confidence interval (CI) = 0.10-0.89; OR = 0.189, CI = 0.063-0.566] and that the subjects in the highest mercury quartile had significantly higher OR of the metabolic syndrome compared with that of the lowest mercury quartile group (OR = 7.35, CI = 1.73-31.1). As part of the metabolic syndrome, the optimal calcium and magnesium concentrations in hair tissue may reflect decreased risk of metabolic syndrome, whereas high mercury concentration in hair tissue may indicate increased risk of metabolic syndrome.

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Section: Discussionmentioning

confidence: 94%

Hair Tissue Mineral Analysis and Metabolic Syndrome

Park

Choi

Nam

2009

Biol Trace Elem Res

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“…Chronic fatigue syndrome patients have sustained elevated levels of peroxynitrite, and this can result in lipid peroxidation, enzyme oxidation, and loss of mitochondrial function as well as changes in cytokine levels that exert a positive feedback on NO production Radi et al, 1994;Pall, 2000]. Although there are small molecules that counteract the excess oxidative capacity of ROS/ RNS, such as glutathione and cysteine, these have been found at lower levels in chronic fatigue syndrome patients [Manuel y Keenoy et al, 2000]. Thus similar to insulin resistance, MS, type 2 diabetes, and other MS-associated diseases aging and fatigue are linked to excess oxidative stress and overproduction of ROS/ RNS, damage to mitochondrial electron transport systems and reduced oxidative phosphorylation capacities [Agadjanyan et al, 2003;Nicolson, 2003;Nicolson and Ellithrope, 2006].…”

Section: Oxidative Damage To Mitochondrial Membranes In Aging and Fatmentioning

confidence: 96%

“…Membrane oxidation modifies lipid structure and can affect lipid fluidity, permeability, and membrane function [Nicolson et al, 1977;Subczynski and Wisniewska, 2000]. In MS-associated diseases and fatiguing illnesses, such as chronic fatigue syndrome, patients show increased susceptibility to oxidative stress, lipid peroxidation, and loss of electron transport function [Logan and Wong, 2001;Manuel y Keenoy et al, 2000.…”

Section: Replacement Of Damaged Mitochondrial Membrane Components By mentioning

confidence: 98%

Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function

Nicolson

2007

J of Cellular Biochemistry

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Metabolic syndrome consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart disease. One of the defects in metabolic syndrome and its associated diseases is excess cellular oxidative stress (mediated by reactive oxygen and nitrogen species, ROS/RNS) and oxidative damage to mitochondrial components, resulting in reduced efficiency of the electron transport chain. Recent evidence indicates that reduced mitochondrial function caused by ROS/RNS membrane oxidation is related to fatigue, a common complaint of MS patients. Lipid replacement therapy (LRT) administered as a nutritional supplement with antioxidants can prevent excess oxidative membrane damage, restore mitochondrial and other cellular membrane functions and reduce fatigue. Recent clinical trials have shown the benefit of LRT plus antioxidants in restoring mitochondrial electron transport function and reducing moderate to severe chronic fatigue. Thus LRT plus antioxidant supplements should be considered for metabolic syndrome patients who suffer to various degrees from fatigue.

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“…The risk of inadequate magnesium intake is particularly high in those affected by chronic conditions and receiving chronic drug treatment (18 -20). Magnesium supplementation has been shown to be beneficial in several conditions, such as neuropsychiatric disorders, ischemic heart disease and cardiac arrhythmias, asthma, diabetes, and chronic fatigue (39,40). Because magnesium supplementation is inexpensive and in general well tolerated, it should be a key consideration in older subjects at particular risk of magnesium deficiency.…”

Section: Discussionmentioning

confidence: 99%

Magnesium and muscle performance in older persons: the InCHIANTI study

Domínguez

Barbagallo

Lauretani

et al. 2006

The American Journal of Clinical Nutrition

121

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Background:The role of magnesium in maintaining muscle integrity and function in older adults is largely unknown. Objective: We aimed to investigate the relation between serum magnesium concentrations and muscle performance in older subjects. Design: Data are from the baseline examination conducted between September 1998 and March 2000 of the InCHIANTI (aging in the Chianti area) study, a prospective epidemiologic survey of risk factors for late-life disability. From among 1453 randomly selected community residents completing a home interview, 1138 men (46%) and women (aged 66.7 Ȁ 15.2 y; x Ȁ SD) with complete data on muscle performance and serum magnesium who were not severely cognitively compromised and had no evidence of kidney disease or hypercalcemia were included in the analysis. Muscle performance was evaluated by grip strength, lower-leg muscle power, knee extension torque, and ankle extension isometric strength and was normalized for age and body mass index (BMI) within each sex. Results: After adjustment for age, sex, BMI, laboratory variables, presence of chronic diseases, muscle area, muscle density, and physical activity level, serum magnesium concentrations were significantly associated with indexes of muscle performance, including grip strength (␤ ҃ 2.0 Ȁ 0.5, P ҃ 0.0002), lower-leg muscle power (␤ ҃ 8.8 Ȁ 2.7, P ҃ 0.001), knee extension torque (␤ ҃ 31.2 Ȁ 7.9, P 0.0001), and ankle extension strength (␤ ҃ 3.8 Ȁ 0.5, P 0.0001). Conclusions:The serum magnesium concentration is an independent correlate of muscle performance in older persons. Whether magnesium supplementation improves muscle function remains to be shown.Am J Clin Nutr 2006;84:419 -26.

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Magnesium Status and Parameters of the Oxidant-Antioxidant Balance in Patients with Chronic Fatigue: Effects of Supplementation with Magnesium

Cited by 77 publications

References 42 publications

Hair Tissue Mineral Analysis and Metabolic Syndrome

Hair Tissue Mineral Analysis and Metabolic Syndrome

Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function

Magnesium and muscle performance in older persons: the InCHIANTI study

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