Magnesia-doped HA/β-TCP ceramics and evaluation of their biocompatibility

Ryu, Hyun; Hong, Kug Sun; Lee, Jung Kun; Kim, Deug Joong; Lee, Jae Hyup; Chang, Bong Soon; Lee, Dong Hoon; Lee, Choon-Ki; Chung, Sung Soo

doi:10.1016/s0142-9612(03)00538-6

Cited by 165 publications

(96 citation statements)

References 24 publications

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“…Furthermore, they exhibit an inhibitory effect both in the nucleation of synthetic HA [4,5] and in biomineralization [6]. This also was observed during sintering HA powder samples [7,8] and may have a substantial influence on the mechanical properties of HA ceramics.…”

Section: Introductionmentioning

confidence: 99%

Magnesium‐substituted hydroxyapatite ceramics

Zyman¹,

Tkachenko

Epple

et al. 2006

Materialwissenschaft Werkst

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The effect of the addition of magnesium (up to 10 wt%, expressed as MgO) on the phase composition, the microstructure and the mechanical properties of hydroxyapatite-based ceramics (HA) was studied by X-ray powder diffraction, infrared spectroscopy, scanning electron microscopy, and mechanical testing. Doping with magnesium did not change the crystal lattice of HA but, due to an isomorphous substitution of Mg 2+ for Ca 2+ , it caused a decrease in the average grain size, an increase of microporosity, a removal of the texture, and the formation of a weak intergranular boundary. The transcrystallite fracture pattern of pure HAwas changed to a predominantly intercrystallite one. This resulted in a decrease in density (down to 2.93 g cm -3), in microhardness (down to 400 MPa), in compressive strength (down to 190 MPa) and in improved plastic properties of the material (increasing the fracture toughness K 1C up to 2.7 MPa m 1/2 , close to that of the bone). It is interesting that the K 1C increase could be only observed for a small concentration of additives (up to 1 wt%), i.e. close to the Mg concentration in natural bone mineral.

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Section: Introductionmentioning

confidence: 99%

Magnesium‐substituted hydroxyapatite ceramics

Zyman¹,

Tkachenko

Epple

et al. 2006

Materialwissenschaft Werkst

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“…However, the MgO peaks are not detected in the XRD patterns of the BCP scaffold (Figure 4), indicating that the free MgO was not presence in the HA/β-TCP mixture. MgO is able to incorporate into either HA or β-TCP [16,17]. However, in this study, MgO was likely incorporated in the HA crystal since the HA composition was significantly reduced after sintering.…”

Section: Porous Sintered Bcpmentioning

confidence: 73%

“…Various preparation techniques have been developed to produce BCP powders such as powder mixing [6], solid-state reaction [7] and decomposition reaction [8]. In this study, however, a simple hydrothermal route has been used to prepare BCP powder using β-TCP as the precursor which allows controlled phase composition.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biphasic Calcium Phosphate by Hydrothermal Route and Conversion to Porous Sintered Scaffold

nbsp¹,

Noor²,

Kasim³

et al. 2013

JBNB

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Biphasic calcium phosphate (BCP) consisting of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) was successfully synthesized by new hydrothermal route using β-TCP as precursor. The X-ray diffraction analysis of as-synthesized powder indicated that β-TCP had been transformed into HA phase and amount of HA formed gradually increased with prolonged time. The results revealed that the recent technique may be able to control the composition of the obtained BCP which would influence the bioresorbability. Porous body of BCP was prepared by impregnation of polymeric sponge template with the slurry of the powder followed by sintering. The X-ray diffraction of porous product revealed that the composition of β-TCP increased after sintering indicating that HA had been decomposed. Porous BCP obtained from the recent technique possessed both macro and micropores structure which are useful for rapid tissue formation. Besides, the recent porous fabrication technique yielded porous BCP which preserved the sponge template morphology, enabling it to fabricate porous material with controlled pores structure.

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“…[1][2][3][4] Schwarz and Miline 5) have shown that silicon deficiency in rats result in skull deformation, with the cranial bones appearing flatter than normal. Magnesium is also undoubtedly one of the most important elements in human body, and closely associated with mineralization of calcined tissues and indirectly influences mineral metabolism.…”

Section: Introductionmentioning

confidence: 99%

Rapid Synthesis and Consolidation of Nanostructured Mg2SiO4-MgAl2O4 Composites

et al. 2011

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Nanopowders of MgO, Al 2 O 3 and SiO 2 were made by high energy ball milling. The rapid sintering of nanostructured MgAl 2 O 4 -Mg 2 SiO 4 composites was investigated by the pulsed current activated sintering process. The advantage of this process is that it allows very quick densification to near theoretical density and inhibition of grain growth. Highly dense nanostructured MgAl 2 O 4 -Mg 2 SiO 4 composites were produced with simultaneous application of 80 MPa pressure and pulsed current of 2800 A within 2 min. The sintering behavior, grain size and mechanical properties of MgAl 2 O 4 -Mg 2 SiO 4 composites were investigated.

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Magnesia-doped HA/β-TCP ceramics and evaluation of their biocompatibility

Cited by 165 publications

References 24 publications

Magnesium‐substituted hydroxyapatite ceramics

Magnesium‐substituted hydroxyapatite ceramics

Synthesis of Biphasic Calcium Phosphate by Hydrothermal Route and Conversion to Porous Sintered Scaffold

Rapid Synthesis and Consolidation of Nanostructured Mg<SUB>2</SUB>SiO<SUB>4</SUB>-MgAl<SUB>2</SUB>O<SUB>4</SUB> Composites

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