Macroporous Biphasic Calcium Phosphate Efficiency in Mastoid Cavity Obliteration: Experimental and Clinical Findings

Abstract

Following our previous experimental studies on the performance of macroporous biphasic calcium phosphate (MBCP) in canine mastoid cavities, we used this material in patients requiring surgical intervention. Twenty-two cases were selected, and in eight specific cases a biopsy specimen was taken. Histologic, ultrastructural, and microanalysis studies were performed. This study demonstrates the effectiveness of MBCP implants as bone graft substitutes for mastoid cavity obliteration. Clinical evaluation of the series and histologic and ultrastructural results demonstrated the bioactivity and osteo-conduction of this material, with partial transformation of MBCP granules into lamellar bone after several months.

Biphasic calcium phosphates: Influence of three synthesis parameters on the HA/β‐TCP ratio

“…The FDM model was validated at another experimental point (F 1 = −0.5; F 3 = −1) representing a 60/40 HA/␤-TCP ratio which seems adapted for human bone ingrowth. [10][11][12][13][14] Second, validation of the FDM theory required the absence of marked interactions between the factors studied. 24 As these two conditions were met, it would appear that our first-order polynomial equation described HA content in BCP correctly in the experimental area studied.…”

“…5,6 They are remarkably biocompatible 7 and their association is considered to be more bioactive 8 and more efficient than HA alone for the repair of periodontal defects, 9 certain orthopedic applications, [10][11][12][13] and oral and maxillofacial surgery. 14 Biphasic calcium phosphates of varying HA/␤-TCP ratios can be prepared by mechanical mixing of ␤-TCP and HA powders in desired quantities or by chemical methods producing calcium-deficient apatites [CDA;…”

Obliteration von Mastoidhöhlen

“…Die Bis 1974 sind also biologische, danach auch alloplastische Materialien, vor allem Keramik in fester, Pulver-oder Granulatform genutzt worden [6][7][8][9][10][11][12][13]. Zunächst war in vielen Fällen das Ziel, aus einer großen unübersichtlichen, sezernierenden Höhle eine kleinere, trockene und übersichtliche Höhle zu erreichen, die sich selbst reinigt und nicht zur Sekretion neigt.…”

Development and clinical cases of injectable bone void filler used in orthopaedic

“…Subsequently, focused studies on BCP by Daculsi et al [8,9] have shown promising results and therefore led to a significant increase in the use of commercial BCP bioceramics as bone substitute materials for orthopaedic and dental applications [10][11][12][13][14][15][16].…”