Biphasic calcium phosphates: Influence of three synthesis parameters on the HA/β‐TCP ratio

Abstract

Hydroxyapatite (HA) contents measurements were conducted on eight biphasic calcium phosphate (BCP) samples obtained by sintering calcium-deficient apatite formed previously by hydrolyzing a dicalcium phosphate dihydrate (DCPD) powder. We evaluated the influences and interactions of three synthesis factors: alkalinity, process duration, and concentration of the water suspension in DCPD. Those parameters were varied simultaneously between two limit levels. Experiments used a factorial design method (FDM) allowing optimization of the number of samples as well as statistical analysis of results. FDM showed that HA content, in a defined experimental area, can be described by a first-order polynomial equation in which the initial alcalinity and the DCPD/water ratio are the major influences. Experiment prove that pH measured at the end of the hydrolysis was predictive of the HA content in the final BCP. This study leads up to an isoresponse line diagram which will allow the synthesis of some BCP with fitted HA/beta-tricalcium phosphate ratios.

A Critical Comparison on Biocompatibility of Different Phases of Sol–Gel Derived Calcium Phosphates as Bone Graft Materials

“…They differ not only in their composition and physical properties from each other and from bone, but also in their rate of absorption 12,22 . The scientific community is still looking for adequate bone graft substitutes despite 40 years of research.…”

Sedimentation Study of Biphasic Calcium Phosphate Particles

“…The BCP mineral phase is an association of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). The suitable proportions of HA (60%) and β-TCP (40%) has provided BCP ceramics with controlled bioactivity and biocompatibility [3]. The viscous phase of IBS is an aqueous polymer solution (hydroxypropylmethylcellulose (HPMC) or sodium carboxymethylcellulose (CMC)).…”

Bioactivity behavior of Si and Mg ion-substituted biphasic calcium phosphate powders

“…최근 Hydroxyapatite(HAp, Ca 10 (PO 4 ) 6 (OH) 2 )와 β-Tricalcium phosphate(β-TCP, Ca 3 (PO 4 ) 2 )의 인산칼슘계 세라믹은 그들의 생체적합성(biocompatibility), 골전도 (osteoconduction), 세포와의 친화성 등의 특성으로 인하 여 골 수복용 이식 재료로 적용되고 있다 [1][2][3][4]. 그러나 두 재료들은 HAp의 비분해성과 β-TCP의 분해성의 독 립적인 분해특성만으로는 임상 성능을 감소시키고 있다.…”

“…그러나 두 재료들은 HAp의 비분해성과 β-TCP의 분해성의 독 립적인 분해특성만으로는 임상 성능을 감소시키고 있다. 그러므로 두 상이 적절히 혼합된 BCP(Biphasic Calcium Phosphate) 세라믹이 생체 내 흡수성이 우수한 물질로 제안되어 연구 중에 있다 [5,6]. 다양한 원소가 쉽게 치환될 수 있는 구조를 가지는 인 산칼슘계 세라믹은 인체 이식 후 인산칼슘계 세라믹 내 에 치환된 여러 가지 이온 성분이 골 조직과의 작용에 의해 골 형성을 촉진한다 [7,8].…”