Sedimentation Study of Biphasic Calcium Phosphate Particles

Fatimi, Ahmed; Tassin, Jean-François; Axelos, Monique; Weiss, Pierre

doi:10.4028/www.scientific.net/kem.361-363.365

Cited by 3 publications

(3 citation statements)

References 15 publications

(17 reference statements)

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“…7) were characterized by a very rapid increase of the force followed by a plateau [15]. Filter pressing [15] and phase separation [35,36] were not observed during measurements and the absence of a final rapid increase of the force after the plateau confirms these results. The injection force depends on needle length (Fig.…”

Section: Injection Of Cap Biomaterialssupporting

confidence: 83%

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Injection of calcium phosphate pastes: prediction of injection force and comparison with experiments

Fatimi¹,

Tassin²,

Bosco³

et al. 2012

J Mater Sci: Mater Med

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Calcium phosphate ceramics suspensions (ICPCS) are used in bone and dental surgery as injectable bone substitutes. This ICPCS biomaterial associates biphasic calcium phosphate (BCP) granules with hydroxypropylmethylcellulose (HPMC) polymer. Different ICPCS were prepared and their rheological properties were evaluated in parallel disks geometry as a function of the BCP weight ratio (35, 40, 45 and 50 %). The suspensions show a strongly increased viscosity as compared to the suspending fluid and the high shear rate part of the flow curve can be fitted with a power law model (Ostwald-de Waele model). The fitting parameters depend on the composition of the suspension. A simple device has been used to characterize extrusion of the paste using a disposable syringe fitted with a needle. The injection pressure of four ICPCS formulations was studied under various conditions (needle length and radius and volumetric flow rate), yielding an important set of data. A theoretical approach based on the capillary flow of non-Newtonian fluids was used to predict the necessary pressure for injection, on the basis of flow curves and extrusion conditions. The extrusion pressure calculated from rheological data shows a quantitative agreement with the experimental one for model fluids (Newtonian and HPMC solution) but also for the suspension, when needles with sufficiently large diameters as compared to the size of particles, are used. Depletion and possibly wall slip is encountered in the suspensions when narrower diameters are used, so that the injection pressure is less than that anticipated. However a constant proportionality factor exists between theory and injection experiments. The approach developed in this study can be used to correlate the rheological parameters to the necessary pressure for injection and defines the pertinent experimental conditions to obtain a quantitative agreement between theory and experiments.

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Section: Injection Of Cap Biomaterialssupporting

confidence: 83%

“…Different formulations of ICPCS were prepared by mixing BCP particles (40-80 lm) with HPMC solution in water (3 % w/w) at different ratios (35,40,45 and 50 % w/w). Samples were sterilized by autoclave Alphaklave Ò 23 (HMCE, Taillis, France) according to the standard pharmaceutical procedure (121°C during 20 min).…”

Section: Injectable Cap Pastementioning

confidence: 99%

Injection of calcium phosphate pastes: prediction of injection force and comparison with experiments

Fatimi¹,

Tassin²,

Bosco³

et al. 2012

J Mater Sci: Mater Med

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“…Case 1 (unrinsed and in situ crosslinked materials): similarly to the typical conditions of use of the HPMC-Si and ICPCS-Si materials [12], 1 volume of 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES) buffer A (pH ¼ 3.6) or 0.5 volume of HEPES buffer B (pH ¼ 3.2) was mixed with 1 volume of the basic mixture of HPMC-Si/ruthenium complex, and in case of labelled ICPCS-Si implantations, 40 or 50 wt% of BCP granules of either 40-80 mm (from Biomatlante, France) or 80-200 mm [32,33] were also added, respectively. One hour to one hour and a half after the addition of the buffer, and while the viscosity of the mixture was low enough (about 0.05-0.2 Pa.s without the BCP granules) [34], 0.5 ml of labelled HPMC-Si or ICPCS-Si were implanted per rabbit bone defect.…”

Section: Preparation Of the Ruthenium Labelled Hpmc-si Hydrogel And Imentioning

confidence: 99%

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

et al. 2009

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a b s t r a c tIn this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.

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Injectable composites for bone repair

Weiss

Fatimi

2010

Biomedical Composites

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Sedimentation Study of Biphasic Calcium Phosphate Particles

Cited by 3 publications

References 15 publications

Injection of calcium phosphate pastes: prediction of injection force and comparison with experiments

Injection of calcium phosphate pastes: prediction of injection force and comparison with experiments

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

Injectable composites for bone repair

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