Development and clinical cases of injectable bone void filler used in orthopaedic

Daculsi, Guy; Durand, M.; Fabre, Thierry; Vogt, F.; Uzel, A.-P.; Rouvillain, J.-L.

doi:10.1016/j.irbm.2012.06.001

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…Ceramics are used to treat bone defects due to their osteoconductivity and/or bioactivity. Synthetic hydroxyapatite (HA) and β‐tricalcium phosphate (β‐TCP) have been commercially available since 1980s and are widely used in dental and orthopedic applications . Ceramic/polymer composites combine the osteoconductivity of ceramics with the ductility of polymers, resulting in a graft that meets many of the targeted properties for a BVF .…”

Section: Introductionmentioning

confidence: 99%

“…Synthetic hydroxyapatite (HA) and b-tricalcium phosphate (b-TCP) have been commercially available since 1980s and are widely used in dental and orthopedic applications. 4 Ceramic/ polymer composites combine the osteoconductivity of ceramics with the ductility of polymers, resulting in a graft that meets many of the targeted properties for a BVF. 5,6 Additionally, the relative degradation rates of the ceramic and polymer phases can be tuned to balance the rates of cellular infiltration, new bone formation, and graft resorption.…”

Section: Introductionmentioning

confidence: 99%

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Remodeling of injectable, low‐viscosity polymer/ceramic bone grafts in a sheep femoral defect model

et al. 2016

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Ceramic/polymer composite bone grafts offer the potential advantage of combining the osteoconductivity of ceramic component with the ductility of polymeric component, resulting in a graft that meets many of the desired properties for bone void fillers (BVF). However, the relative contributions of the polymer and ceramic components to bone healing are not well understood. In this study, we compared remodeling of low-viscosity (LV) ceramic/poly(ester urethane) composites to a ceramic BVF control in a sheep femoral condyle plug defect model. LV composites incorporating either ceramic (LV/CM) or allograft bone (LV/A) particles were evaluated. We hypothesized that LV/CM composites which have the advantageous handling properties of injectability, flowability, and settability would heal comparably to the CM control, which was evaluated for up to 2 years to study its long-term degradation properties. Remodeling of LV/CM was comparable to that observed for the CM control, as evidenced by new bone formation on the surface of the ceramic particles. At early time points (4 months), LV/CM composites healed similar to the ceramic clinical control, while LV/A components showed more variable healing due to osteoclast-mediated resorption of the allograft particles. At longer time points (12-15 months), healing of LV/CM composites was more variable due to the nonhomogeneous distribution and lower concentration of the ceramic particles compared to the ceramic clinical control. Resorption of the ceramic particles was almost complete at 2 years. This study highlights the importance of optimizing the loading and distribution of ceramic particles in polymer/ceramic composites to maximize bone healing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2333-2343, 2017.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remodeling of injectable, low‐viscosity polymer/ceramic bone grafts in a sheep femoral defect model

et al. 2016

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“…The most common synthetic alloplastic biomaterials in current use are calcium phosphate-based (Ca-P) bioceramics [ 38 ], and these have been extensively investigated because their mineral chemistry resembles that of human bone. The present HA/β-TCP has been used successfully for guided bone regeneration in multiple dental and orthopedics treatments [ 39 , 40 , 41 ] and has been shown to safely and efficiently support dental implants [ 42 ]. These outcomes could be improved in HA/β-TCP with Ar-GDP surface treatments that decrease total surface contaminant contents and prepare stoichiometric HA/β-TCP surfaces in a highly controlled manner.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Osteoblastic-Like Cell Activity by Glow Discharge Plasma Surface Modified Hydroxyapatite/β-Tricalcium Phosphate Bone Substitute

et al. 2017

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Glow discharge plasma (GDP) treatments of biomaterials, such as hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composites, produce surfaces with fewer contaminants and may facilitate cell attachment and enhance bone regeneration. Thus, in this study we used argon glow discharge plasma (Ar-GDP) treatments to modify HA/β-TCP particle surfaces and investigated the physical and chemical properties of the resulting particles (HA/β-TCP + Ar-GDP). The HA/β-TCP particles were treated with GDP for 15 min in argon gas at room temperature under the following conditions: power: 80 W; frequency: 13.56 MHz; pressure: 100 mTorr. Scanning electron microscope (SEM) observations showed similar rough surfaces of HA/β-TCP + Ar-GDP HA/β-TCP particles, and energy dispersive spectrometry analyses showed that HA/β-TCP surfaces had more contaminants than HA/β-TCP + Ar-GDP surfaces. Ca/P mole ratios in HA/β-TCP and HA/β-TCP + Ar-GDP were 1.34 and 1.58, respectively. Both biomaterials presented maximal intensities of X-ray diffraction patterns at 27° with 600 a.u. At 25° and 40°, HA/β-TCP + Ar-GDP and HA/β-TCP particles had peaks of 200 a.u., which are similar to XRD intensities of human bone. In subsequent comparisons, MG-63 cell viability and differentiation into osteoblast-like cells were assessed on HA/β-TCP and HA/β-TCP + Ar-GDP surfaces, and Ar-GDP treatments led to improved cell growth and alkaline phosphatase activities. The present data indicate that GDP surface treatment modified HA/β-TCP surfaces by eliminating contaminants, and the resulting graft material enhanced bone regeneration.

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“…9 Injectable biomaterials were developed by combining BCP granules with natural (e.g., fibrin, 12 hyaluronic acid 13 ) or hemisynthetic (e.g., cellulose derivatives 14 ) polymers to form putties and pastes; 15 yet with poor outcomes regarding short-term implant stability and granules wash-out by body fluids. 14,16 In situ forming hydrogels that can be injected into a tissue in a minimally invasive fashion are a promising solution to improve handling, injectability, and stability of the biomater-40-80 µm) with a 60/40 hydroxyapatite/β-tricalcium phosphate weight ratio were purchased from Biomatlante (France) (Fig. A1 †).…”

Section: Introductionmentioning

confidence: 99%

Injectable silanized hyaluronic acid hydrogel/biphasic calcium phosphate granule composites with improved handling and biodegradability promote bone regeneration in rabbits

et al. 2021

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Development and clinical cases of injectable bone void filler used in orthopaedic

Cited by 7 publications

References 18 publications

Remodeling of injectable, low‐viscosity polymer/ceramic bone grafts in a sheep femoral defect model

Remodeling of injectable, low‐viscosity polymer/ceramic bone grafts in a sheep femoral defect model

Enhancement of Osteoblastic-Like Cell Activity by Glow Discharge Plasma Surface Modified Hydroxyapatite/β-Tricalcium Phosphate Bone Substitute

Injectable silanized hyaluronic acid hydrogel/biphasic calcium phosphate granule composites with improved handling and biodegradability promote bone regeneration in rabbits

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