Macrophages in bone fracture healing: Their essential role in endochondral ossification

Schlundt, Claudia; Khassawna, Thaqif El; Serra, Alessandro; Dienelt, Anke; Wendler, Sebastian; Schell, Hanna; Rooijen, Nico van; Radbruch, Andreas; Lucius, Richard; Hartmann, Susanne; Duda, Georg N.; Schmidt‐Bleek, Katharina

doi:10.1016/j.bone.2015.10.019

Cited by 452 publications

(483 citation statements)

References 57 publications

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“…This decreased mineralization is probably associated with the lack of osteoblasts originated from macrophage-enhanced osteoblastic differentiation (Vi et al, 2015). Claudia et al have proven that M2 macrophage enhancement driven by IL-4 and IL-13 improved bone remodeling (Schlundt et al, 2015). The M1 macrophage expresses high levels of pro-inflammatory cytokines and reactive nitrogen and oxygen intermediates, which exert microbicidal and tumoricidal activity.…”

Section: Excreted Factorsmentioning

confidence: 99%

“…In the course of wound healing, macrophage knockout mice exhibit disorganized cytokine expression at the wound bed, and the chaos resulted in disabled injury repair (Mirza et al, 2009). During fracture healing, either Fas- (Raggatt et al, 2014) or clodronate liposome injectioninduced (Schlundt et al, 2015) macrophage depletion led to prolonged union and impaired mineralization. This finding is concurrent with the in vitro experiment indicating that the removal of macrophages diminished osteoblast mineralization (Chang et al, 2008).…”

Section: Excreted Factorsmentioning

confidence: 99%

“…Schlundt et al produced unilateral closed fractures in 8-week-old mice (Schlundt et al, 2015 (Van Rooijen et al, 1984). This compound has been shown to have high affinity for calcium and, thus, adheres to the mononuclear phagocyte system (MPS).…”

Section: Fracture Healingmentioning

confidence: 99%

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Snapshot: Targeting Macrophages as a Candidate for Tissue Regeneration

Zhang¹,

Yang²,

Yang³

et al. 2018

Current Issues in Molecular Biology

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Section: Excreted Factorsmentioning

confidence: 99%

Section: Excreted Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Snapshot: Targeting Macrophages as a Candidate for Tissue Regeneration

Zhang¹,

Yang²,

Yang³

et al. 2018

Current Issues in Molecular Biology

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“…"Osteomacs" is a special term for these macrophages that are believed to closely interact with osteoblasts. Interestingly, macrophage depletion can lead both to increased membranous bone formation, in the periosteum [47], and decreased membranous bone formation, in the medullary space [49]. The anabolic effect of macrophages has been partly linked to Oncostatin M, a cytokine related to IL-6.…”

Section: Inflammation Plays Different Roles In Cancellous and Corticamentioning

confidence: 99%

“…They are key players in both the onset and resolution of inflammation [46] and are in the broadest of definitions divided into the inflammatory M1 subcategory and the anabolic M2 subcategory. In the shaft macrophages seem important for collagen deposition and for the conversion of cartilage into bone [47]. Their depletion leads to impaired callus formation [48] and impaired shaft fracture healing.…”

Section: Inflammation Plays Different Roles In Cancellous and Corticamentioning

confidence: 99%

Metaphyseal Fracture Healing

Sandberg¹

2016

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Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology

Armiento

Hatt

Rosenberg

et al. 2020

Adv Funct Materials

152

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Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has greatly advanced the understanding of how bone heals and has led to marked success in the treatment of bone injuries. Nevertheless, the effective treatment of nonunions and large bone defects continues to present a challenge for orthopedic surgeons. Biomaterials provide researchers with a powerful instrument to potentially guide effective bone tissue regeneration in challenging healing environments. However, the most appropriate biomaterial for bone tissue engineering continues to be an area of intense debate. Indeed, the mechanical properties of real bone can be reproduced in vitro but the development of a functional bone substitute goes beyond the sole mechanical properties. The faithful reproduction of bone as a functional organ requires the combination of different cell types and temporal regulation of the molecular signaling involved during the different stages of bone formation and regeneration. This is not at all a trivial task. Herein, critical aspects of bone healing/regeneration including mechanical loading, inflammation, vascularization, and innervation are described. The success and the challenges behind the development of biomaterials, and the technologies used to functionalize them, in order to support the underlying cellular mechanisms are also highlighted.

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Macrophages in bone fracture healing: Their essential role in endochondral ossification

Cited by 452 publications

References 57 publications

Snapshot: Targeting Macrophages as a Candidate for Tissue Regeneration

Snapshot: Targeting Macrophages as a Candidate for Tissue Regeneration

Metaphyseal Fracture Healing

Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology

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