Macrophage polarization in wound healing: role of aloe vera/chitosan nanohydrogel

Ashouri, Fatemeh; Beyranvand, Fatemeh; Boroujeni, Nasim Beigi; Tavafi, Majid; Sheikhian, Ali; Varzi, Ali Mohammad; Shahrokhi, Somayeh

doi:10.1007/s13346-019-00643-0

Cited by 35 publications

(27 citation statements)

References 37 publications

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“…In vitro studies have shown that primary macrophages inoculated into high molecular weight extracted keratin and keratin peptide coatings facilitated differentiation into M2c macrophages with anti-inflammatory behavior ( 190 ). Chitosan is similar to glycosaminoglycan in ECM, and filmed chitosan can promote higher macrophage production of IL-10 and TGF-β1 anti-inflammatory cytokines as an indication of the M2 phenotype ( 193 ). Therefore, immunomodulatory biomaterials with the goal of promoting macrophage polarization present an innovative repair strategy for chronic wounds.…”

Section: Biological Treatment For Restoration Of Macrophage Functionmentioning

confidence: 99%

Macrophage Related Chronic Inflammation in Non-Healing Wounds

et al. 2021

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Persistent hyper-inflammation is a distinguishing pathophysiological characteristic of chronic wounds, and macrophage malfunction is considered as a major contributor thereof. In this review, we describe the origin and heterogeneity of macrophages during wound healing, and compare macrophage function in healing and non-healing wounds. We consider extrinsic and intrinsic factors driving wound macrophage dysregulation, and review systemic and topical therapeutic approaches for the restoration of macrophage response. Multidimensional analysis is highlighted through the integration of various high-throughput technologies, used to assess the diversity and activation states as well as cellular communication of macrophages in healing and non-healing wound. This research fills the gaps in current literature and provides the promising therapeutic interventions for chronic wounds.

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Section: Biological Treatment For Restoration Of Macrophage Functionmentioning

confidence: 99%

Macrophage Related Chronic Inflammation in Non-Healing Wounds

et al. 2021

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“…This indicates that the number of each type of activated macrophage may change during the wound healing process. In the middle and late stages of healing, M2 macrophages predominate [20]. These ndings show that different types of macrophage activation during the wound healing process uctuate in an orderly way.…”

Section: Discussionmentioning

confidence: 64%

Silver Nanoparticles Can Relieve Progressive Necrosis by Regulating Macrophage Activation in Burn Wounds

You

Wang

et al. 2021

Preprint

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Purpose: To investigat the positive influence of AgNP on preventing early burn-wound progression.Patients and methods: After a deep burn, progression of burns may occur in the initial or surrounding area，even after thermal factors have been removed. Due to the influence of many factors such as residual heat, the risk of burn stagnant area deterioration is very high which is considered to be salvable. Silver nanoparticles (AgNP), which has been wide used in burns, is a strong antibacterial agent that has been reported to regulate inflammation. Hence, to investigat the positive influence of AgNP on avoid early burn wound progressive deterioration, a isomorphic “comb” burn animal model was made in this study which were treated with silver nanoparticles. The wound tissues were taken for molecular biological and histological evaluation, which revealed that AgNP alleviated histological deterioration in burn stagnant area. Results: Furthermore, AgNP can alleviate the early progressive necrosis and inflammatory response of burn wound, which was accociated with excitation in M2 macrophage and a suppression of M1 macrophage.Conclusion: In conclusion, we demonstrate that AgNP has a protective effect on acute burn wound deterioration in a rat model. It might be regulated by the macrophage activation-induced inﬂammation and apoptosis.

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“…As a traditional natural medicine, AVG possesses a variety of biological effects, including anti-inflammatory, antioxidative, and antipigmentation effects, which are beneficial for acne treatment and repair of skin lesions (31,32). The neutral polysaccharides, aloe mannan and acemannan separated from the gel part of aloe leaves have been identified to have antiinflammatory and immunosuppressive effects by reducing the adhesion of leukocytes and the level of TNF-α and ameliorating the capability of self-repair by inhibiting thromboxane (an inhibitor of lesion repair) (33)(34)(35). The oxidation reaction of skin lesions is also one of the main reasons that prolongs the process of lesion repair.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne

Zhong

Zhang

et al. 2021

Front. Med.

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Background: Acne is a chronic disorder that affects almost 80% of adolescents and young adults, causing psychological and emotional distress. However, the current treatments for acne are either ineffective or have many side effects. This study was designed to confirm and objectively quantify the effect of a new non-drug combined therapy on acne.Methods: This study innovatively utilized ultrasound, which enhanced the absorption of aloe vera gel, and soft mask to make a purely physical method without any drugs. In both the treatment group and control group, the number of papules/pustules and the area of hyperpigmented lesions were counted, and a smart mirror intelligent face system was used before and after the combined therapy. Alterations in the skin functional index were recorded and analyzed statistically.Results: In the treatment group, the combined therapy significantly reduced the number of papules and the area of hyperpigmented lesions and improved skin roughness and local blood circulation. In the control group, there was no obvious improvement over 2 months.Conclusion: This study suggests that the new non-drug combined therapy significantly improved acne, which provided experimental evidence and treatment guidance for patients with mild to severe acne, especially patients with moderate acne. This new therapy may possibly be an appropriate method for patients who seek topical treatments with mild side effects and low antibiotic resistance rates.

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Macrophage polarization in wound healing: role of aloe vera/chitosan nanohydrogel

Cited by 35 publications

References 37 publications

Macrophage Related Chronic Inflammation in Non-Healing Wounds

Macrophage Related Chronic Inflammation in Non-Healing Wounds

Silver Nanoparticles Can Relieve Progressive Necrosis by Regulating Macrophage Activation in Burn Wounds

Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne

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