Silver Nanoparticles Can Relieve Progressive Necrosis by Regulating Macrophage Activation in Burn Wounds

Abstract

Purpose: To investigat the positive influence of AgNP on preventing early burn-wound progression.Patients and methods: After a deep burn, progression of burns may occur in the initial or surrounding area，even after thermal factors have been removed. Due to the influence of many factors such as residual heat, the risk of burn stagnant area deterioration is very high which is considered to be salvable. Silver nanoparticles (AgNP), which has been wide used in burns, is a strong antibacterial agent that has been reported to regulate inflammation. Hence, to investigat the positive influence of AgNP on avoid early burn wound progressive deterioration, a isomorphic “comb” burn animal model was made in this study which were treated with silver nanoparticles. The wound tissues were taken for molecular biological and histological evaluation, which revealed that AgNP alleviated histological deterioration in burn stagnant area. Results: Furthermore, AgNP can alleviate the early progressive necrosis and inflammatory response of burn wound, which was accociated with excitation in M2 macrophage and a suppression of M1 macrophage.Conclusion: In conclusion, we demonstrate that AgNP has a protective effect on acute burn wound deterioration in a rat model. It might be regulated by the macrophage activation-induced inflammation and apoptosis.