Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

Khatoon, Nafeesa; Zhang, Zefei; Zhou, Chunhui; Chu, Maoquan

doi:10.1039/d1bm01664d

Cited by 73 publications

(64 citation statements)

References 103 publications

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“…M1 macrophages play a key role in activating adaptive immunity for a stronger antitumor immune response. [37,39,42,67] M1 macrophages secrete several proinflammatory cytokines, including TNF-α, IL-6, IL-12, and IL-1β. They also secrete chemokines such as CXCL-10, reactive oxygen species (ROS) and nitric oxide (NO).…”

Section: Phenotypic Diversity Of Macrophagesmentioning

confidence: 99%

“…[102] In situ packaging of NPs has also been described to yield high quality cell membrane-coated NPs. [9,39] This method consists of incubating living cells with NPs for collecting cell-secreted vesicles containing the exogenous NPs. The in situ packaging technique has the advantage of preserving the integrity of cell membranes and surface proteins.…”

Section: Coating Nanoparticle Cores With Extracted Cell Membranesmentioning

confidence: 99%

“…MCM-coated NPs mainly derive from the novelty and infancy of this biomimetic technology, including 1) the high complexity of the preparation methods, 2) the heterogeneity of white blood cell functions depending on the cell source (e.g., gender, age, and health conditions), 3) possible epigenetic modification of white blood cells during isolation and purification procedures, 4) immunogenicity, 5) poor reproducibility, 6) issues related to large-scale production, and 7) safety concerns regarding the possibility of coating techniques damaging the integrity and structure of membrane proteins and compromise the biofunctionality of cell membranes. [18,21,39,42,66,101] Furthermore, the lack of understanding of the triggering mechanisms of macrophage migration and polarization, and the high complexity of the immune response within the tumor microenvironment, are concerns that need to be addressed, likely through the use of imaging techniques that can monitor the distribution and accumulation of macrophages in pathological tissues. [41,42] Using immune cell membranes to functionalize the NPs via top-down approaches has emerged as a versatile and very promi sing strategy to prolong the blood circulation time in vivo, and achieve a more precise and efficient accumulation of these nanosystems in inflamed, infectious, and neoplastic tissues.…”

Section: Challenges In Clinical Translation and Future Prospectivesmentioning

confidence: 99%

“…Ensuring reproducibility between batches is very challenging, not only because white blood cells may undergo changes in gene expression during in vitro manipulation, but also their functions may fluctuate according to the source. [ 18,39 ] Therefore, there is an emerging need to develop novel large‐scale production techniques that can reduce batch‐to‐batch variability and ensure the properties and quality of the macrophages. [ 41,42 ]…”

Section: Challenges In Clinical Translation and Future Prospectivesmentioning

confidence: 99%

“…• Reduced fusion efficiency (<1% of the NPs possess a cell membrane coating) [39] Abbreviation: NP, nanoparticle. capable of converting near-infrared light excitation into visible light emission).…”

Section: Electrostatic Interactionmentioning

confidence: 99%

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

et al. 2022

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Biomimetic approaches utilize natural cell membrane-derived nanovesicles to camouflage nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell membrane-coating technology is inspired by naturally occurring intercellular interactions, to efficiently guide nanostructures to the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, the intrinsic biocompatibility of cell membranes allows the crossing of biological barriers and avoids elimination by the immune system. This results in enhanced blood circulation time and lower toxicity in vivo. Macrophages are the major phagocytic cells of the innate immune system. They are equipped with a complex repertoire of surface receptors, enabling them to respond to biological signals, and to exhibit a natural tropism to inflammatory sites and tumorous tissues. Macrophage cell membranefunctionalized nanosystems are designed to combine the advantages of both macrophages and nanomaterials, improving the ability of those nanosystems to reach target sites. Recent studies have demonstrated the potential of these biomimetic nanosystems for targeted delivery of drugs and imaging agents to tumors, inflammatory, and infected sites. The present review covers the preparation and biomedical applications of macrophage cell membranecoated nanosystems. Challenges and future perspectives in the development of these membrane-coated nanosystems are addressed.

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Section: Phenotypic Diversity Of Macrophagesmentioning

confidence: 99%

Section: Coating Nanoparticle Cores With Extracted Cell Membranesmentioning

confidence: 99%

Section: Challenges In Clinical Translation and Future Prospectivesmentioning

confidence: 99%

Section: Challenges In Clinical Translation and Future Prospectivesmentioning

confidence: 99%

Section: Electrostatic Interactionmentioning

confidence: 99%

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

et al. 2022

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Immunocyte‐Derived Nanodrugs for Cancer Therapy

Zhu

Wang

Jia

et al. 2022

Adv Funct Materials

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Recent years have witnessed the rapid development of the biomimetic nanotechnology regarding the use of certain components (such as cell membranes, extracellular vesicles, proteins, etc.) derived from different cells to fabricate nanoparticles (NPs) for cancer treatment. These biomimetic NPs usually inherit certain abilities from their parental cells, such as long blood circulation, capacity to escape from mononuclear phagocytic system, active tumor‐targeting, and controlled drug release. Immunocytes play vital roles in different tumor progression stages, and can quickly and accurately react to tumor progression via specific targeting and immune surveillance. Therefore, increasing studies focus on constructing biomimetic NPs with components isolated from immunocytes. This review introduces four main types of immunocyte‐derived nanodrugs—membrane‐coated NPs, exosomes or extracellular vesicles, functional protein‐incorporated NPs, and exosome mimetics—and summarizes the recent advances of these nanodrugs for cancer therapy. Some current challenges and future research directions of immunocyte‐derived nanodrugs are also proposed. It is hoped that this review may help researchers in the related field to design new immunocyte‐derived nanomedicines and promote their preclinical and clinical applications in the near future.

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Microfluidics‐Prepared Ultra‐small Biomimetic Nanovesicles for Brain Tumor Targeting

Wang,

Ma,

et al. 2023

Adv Healthcare Materials

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Blood‐brain‐barrier (BBB) serves as a fatal guard of the central nervous system as well as a formidable obstacle for the treatment of brain diseases such as brain tumors. Cell membrane‐derived nanomedicines are promising drug carriers to achieve BBB‐penetrating and brain lesion targeting. However, the challenge of precise size control of such nanomedicines has severely limited their therapeutic effect and clinical application in brain diseases. To address this problem, this work develops a microfluidic mixing platform that enables the fabrication of cell membrane‐derived nanovesicles with precise controllability and tunability in particle size and component. Sub‐100 nm macrophage plasma membrane‐derived vesicles as small as 51 nm (nanoscale macrophage vesicles, NMVs), with a narrow size distribution (polydispersity index, PDI: 0.27) and a high drug loading rate (up to 89% for indocyanine green‐loaded NMVs, NMVs@ICG (ICG is indocyanine green)), are achieved through a one‐step process. Compared to beyond‐100 nm macrophage cell membrane vesicles (general macrophage vesicles, GMVs) prepared via the traditional methods, the new NMVs exhibits rapid (within 1 h post‐injection) and enhanced orthotopic glioma targeting (up to 78% enhancement), with no extra surface modification. This work demonstrates the great potential of such real‐nanoscale cell membrane‐derived nanomedicines in targeted brain tumor theranostics.

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Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

Abstract: The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

Cited by 73 publications

References 103 publications

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Immunocyte‐Derived Nanodrugs for Cancer Therapy

Microfluidics‐Prepared Ultra‐small Biomimetic Nanovesicles for Brain Tumor Targeting

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