The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

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Using magnetomechanical force to kill cancer cells has attracted great attention recently. This study presents novel hedgehog‐like microspheres composed of needle‐like magnetic nanoparticles with carbon and gold double shells. Using a novel low‐frequency vibrating magnetic field (VMF), these microspheres with sharp surfaces can seriously damage cancer cells and strongly inhibit mouse tumor growth through mechanical force. The cell killing efficiency depends on VMF exposure time, frequency, strength, and microsphere concentration. The maximum mechanical force generated by one microsphere acting on a cancer cell under a VMF is about 35.79 pN. The microspheres also induce photothermal ablation after being triggered by near‐infrared laser irradiation. Mouse tumors could not be detected after treatment with the synergistic stimuli of mechanical force and photothermal ablation. These results reveal a simple and highly efficient strategy using magnetic microspheres for local treatment of solid tumors in a remote and noninvasive manner.

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A simple and time-saving method of electrodeposition was found to fabricate the superhydrophobic Zinc surface on the steel substrate. The surface morphologies and chemical compositions were characterized by using scanning electron microscope, Fourier transform infrared spectrometry and X-ray photoelectron spectroscopy. The results show that the as-prepared surfaces form micro/nano rough structures evolved from the as-prepared surfaces which have been modified by stearic acid, and exhibit good superhydrophobicity with a water contact angle of 157.2° as well as a sliding angle of 5.2°. Interestingly, the superhydrophobic Zinc surface can realize an effective reversible switching between superhydrophobicity and superhydrophilicity after being annealed and modified alternatively, with a fast the wetting switching process costing only 16 min for each cycle. Moreover, polarization curves measurements demonstrate that the superhydrophobic Zinc surface has good anticorrosion properties that can provide greater protection for the bare steel substrate. It is believed that an effective, rapid and eco-friendly approach has been invented to prepare large-area superhydrophobic surface, which shows reversible wettability switching and anticorrosion on the steel substrate for great potential applications, and easily extended to other metal substrates.

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