Macrophage diversity in cancer revisited in the era of single-cell omics

Ma, Ruoyu; Black, Annabel; Qian, Bin‐Zhi

doi:10.1016/j.it.2022.04.008

Cited by 195 publications

(189 citation statements)

References 119 publications

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“…Tumor associated monocyte-derived macrophages are classified by their activation state, previously grouped into the classically activated M1 (anti-tumor effects) or alternatively activated M2 group (pro-tumor effects) ( 96 ). Proinflammatory cytokines such as IFN-γ and TNF-α, as well as TLR (toll-like receptor) ligands, are associated with the M1-like characteristics, while anti-inflammatory cytokines such as IL-4, IL-3, and TGF-β are associated with the M2-like characteristics ( 97 , 98 ). However, this dichotomy of M1-M2 macrophages is more complex and nuanced with a broader range of macrophage phenotypes and function along the spectrum defined by the M1-M2 extremes.…”

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

“…Thus, rather than the dichotomous M1-M2 model, distinguishing macrophages through the expression of gene clusters, defining signatures, or inducing stimuli, may be a more accurate depiction of macrophages diversity ( 100 ). In a model generated through single cell -omics, and spanning multiple cancer types, seven groups of TAMs were described with varying signature genes, enriched pathways, and predicated function: interferon-primed TAMs (IFN-TAMs), immune regulatory TAMs (Reg-TAMs), inflammatory cytokine-enriched TAMs (Inflam-TAMs), lipid-associated TAMs (LA-TAMs), pro-angiogenic TAMs (Angio-TAMs), RTM-like TAMs (RTM-TAMs), and proliferating TAMs (Prolif-TAMs) ( 98 ). IFN-TAMs most closely resemble M1-like macrophages, but have an immunosuppressive function through tryptophan degradation and Treg recruitment ( 101 ).…”

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

“…IFN-TAMs most closely resemble M1-like macrophages, but have an immunosuppressive function through tryptophan degradation and Treg recruitment ( 101 ). Reg-TAMs most closely resemble M2-like macrophages with an immunosuppressive function regulated by triggering receptor expressed on myeloid cells 2 (TREM2) with characteristics dependent on the signature genes induced in specific cancers ( 98 , 102 ). Inflam-TAMs are involved in the tumor inflammatory response, aiding in recruiting and regulating immune cells to the site of inflammation ( 98 ).…”

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

“…Reg-TAMs most closely resemble M2-like macrophages with an immunosuppressive function regulated by triggering receptor expressed on myeloid cells 2 (TREM2) with characteristics dependent on the signature genes induced in specific cancers ( 98 , 102 ). Inflam-TAMs are involved in the tumor inflammatory response, aiding in recruiting and regulating immune cells to the site of inflammation ( 98 ). Angio-TAMs are involved in tumor progression, tumor cell intravasation, extravasation, and chemotherapy resistance with a large population seen in hypoxic regions of the GBM TME, and are associated with worse patient prognosis ( 103 – 105 ).…”

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

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Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization

et al. 2022

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Glioblastoma (GBM) is an extremely aggressive and incurable primary brain tumor with a 10-year survival of just 0.71%. Cancer stem cells (CSCs) are thought to seed GBM’s inevitable recurrence by evading standard of care treatment, which combines surgical resection, radiotherapy, and chemotherapy, contributing to this grim prognosis. Effective targeting of CSCs could result in insights into GBM treatment resistance and development of novel treatment paradigms. There is a major ongoing effort to characterize CSCs, understand their interactions with the tumor microenvironment, and identify ways to eliminate them. This review discusses the diversity of CSC lineages present in GBM and how this glioma stem cell (GSC) mosaicism drives global intratumoral heterogeneity constituted by complex and spatially distinct local microenvironments. We review how a tumor’s diverse CSC populations orchestrate and interact with the environment, especially the immune landscape. We also discuss how to map this intricate GBM ecosystem through the lens of metabolism and immunology to find vulnerabilities and new ways to disrupt the equilibrium of the system to achieve improved disease outcome.

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Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

Section: Heterogeneity Of Immune Cells In Gbm Tmementioning

confidence: 99%

See 2 more Smart Citations

Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization

et al. 2022

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“…However, this oversimplified and widely used nomenclature used, proposed 20 years ago, now refers the "M2-like" phenotype as the cells that have antiinflammatory characteristics, which produce TGFβ and are activated by IL-13 or IL-4. On the other hand, "M1-like" macrophages are pro-inflammatory and activated by IFN-g, TNFa and Toll-like receptor (TLR) ligands [75,76]. For many years, it was thought that the brain was immune privileged only with the presence of specific immune cells called microglial cells, but recently it was shown that was not entirely true [77,78].…”

Section: Tumor Microenvironment Crosstalkmentioning

confidence: 99%

The Interface of Cancer, Their Microenvironment and Nanotechnology

Roque¹,

Matias²,

Bal鏰-Silva³

et al. 2022

Oncologie

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Cancer is one of the deadliest diseases with a cure far from being found. Despite the extraordinary advances in the therapy approaches, only a few patients respond to treatments. The tumor microenvironment (TME) plays a crucial role in cancer progression by contributing to the chemoresistance. Thus, emerging efforts are being made in nanotechnology research focusing on nanoparticles' potential role and their application in immune system modulation. Moreover, the omics have contributed to bioengineering and nanotechnology development by elucidating the mechanisms of cancer and specific biomarkers that could be used as new therapeutic targets. Furthermore, the non-coding microRNA as a target for cancer treatment and creation of organoids for the study of new treatments helped for the new therapeutics' era called personalized medicine. Here we will discuss the role played by TME in tumor initiation and progression we will describe the recent nanotechnology applied to cancer treatment. Specifically, we will describe the potential role of nanoparticles (NPs) and their application in immune system modulation, ultimately leading to circumventing tumor cell proliferation.

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Microglia and macrophages in glioblastoma: landscapes and treatment directions

Solomou,

Young,

Bulstrode

2024

Molecular Oncology

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Glioblastoma is the most common primary malignant tumour of the central nervous system and remains uniformly and rapidly fatal. The tumour‐associated macrophage (TAM) compartment comprises brain‐resident microglia and bone marrow‐derived macrophages (BMDMs) recruited from the periphery. Immune‐suppressive and tumour‐supportive TAM cell states predominate in glioblastoma, and immunotherapies, which have achieved striking success in other solid tumours have consistently failed to improve survival in this ‘immune‐cold’ niche context. Hypoxic and necrotic regions in the tumour core are found to enrich, especially in anti‐inflammatory and immune‐suppressive TAM cell states. Microglia predominate at the invasive tumour margin and express pro‐inflammatory and interferon TAM cell signatures. Depletion of TAMs, or repolarisation towards a pro‐inflammatory state, are appealing therapeutic strategies and will depend on effective understanding and classification of TAM cell ontogeny and state based on new single‐cell and spatial multi‐omic in situ profiling. Here, we explore the application of these datasets to expand and refine TAM characterisation, to inform improved modelling approaches, and ultimately underpin the effective manipulation of function.

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Macrophage diversity in cancer revisited in the era of single-cell omics

Cited by 195 publications

References 119 publications

Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization

Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization

The Interface of Cancer, Their Microenvironment and Nanotechnology

Microglia and macrophages in glioblastoma: landscapes and treatment directions

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