Microglia and macrophages in glioblastoma: landscapes and treatment directions
Georgios Solomou,
Adam M. H. Young,
Harry J. C. J. Bulstrode
Abstract:Glioblastoma is the most common primary malignant tumour of the central nervous system and remains uniformly and rapidly fatal. The tumour‐associated macrophage (TAM) compartment comprises brain‐resident microglia and bone marrow‐derived macrophages (BMDMs) recruited from the periphery. Immune‐suppressive and tumour‐supportive TAM cell states predominate in glioblastoma, and immunotherapies, which have achieved striking success in other solid tumours have consistently failed to improve survival in this ‘immune… Show more
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