Macrophage-Derived IL-1β Regulates Emergency Myelopoiesis via the NF-κB and C/ebpβ in Zebrafish

Wei, Zongfang; Li, Chenzheng; Zhang, Yangping; Lin, Chia-Chen; Zhang, Yiyue; Shu, Liping; Luo, Lingfei; Zhuo, Jian; Li, Li

doi:10.4049/jimmunol.2000473

Cited by 9 publications

(11 citation statements)

References 52 publications

(87 reference statements)

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“…Macrophage-derived il1β actives nf-κb and c/ebpβ, two fast-reactive transcription factors, rapidly. In an LPS-induced systemic infection zebrafish model, the macrophage is the first cell type to detect LPS and secret il1β, which is further responded to by MPCs, rather than HSPCs, expanding myelopoiesis through the synergistic cooperation of nf-κb and c/ebpβ (Wei et al 2020 ).…”

Section: The Myelopoiesis Of Zebrafishmentioning

confidence: 99%

Zebrafish: a convenient tool for myelopoiesis research

Jing

2023

Cell Regen

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Myelopoiesis is the process in which the mature myeloid cells, including monocytes/macrophages and granulocytes, are developed. Irregular myelopoiesis may cause and deteriorate a variety of hematopoietic malignancies such as leukemia. Myeloid cells and their precursors are difficult to capture in circulation, let alone observe them in real time. For decades, researchers had to face these difficulties, particularly in in-vivo studies. As a unique animal model, zebrafish possesses numerous advantages like body transparency and convenient genetic manipulation, which is very suitable in myelopoiesis research. Here we review current knowledge on the origin and regulation of myeloid development and how zebrafish models were applied in these studies.

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Section: The Myelopoiesis Of Zebrafishmentioning

confidence: 99%

Zebrafish: a convenient tool for myelopoiesis research

Jing

2023

Cell Regen

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“…Similarly, inhibition of the components of the IL1β pathway, such as caspase-1, reduces leukocyte recruitment to the wound and also NFκB activity [198]. IL1β also regulates infection-driven emergency myelopoiesis via NF-κB and C/ebpβ [203]. Finally, both TNFα and IL1β play important functions in regeneration [52,85,204].…”

Section: Cytokines (Lymphotoxins and Interleukins)mentioning

confidence: 99%

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

Leiba

Özbilgiç

Hernández

et al. 2023

Biology

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Inflammation is a hallmark of the physiological response to aggressions. It is orchestrated by a plethora of molecules that detect the danger, signal intracellularly, and activate immune mechanisms to fight the threat. Understanding these processes at a level that allows to modulate their fate in a pathological context strongly relies on in vivo studies, as these can capture the complexity of the whole process and integrate the intricate interplay between the cellular and molecular actors of inflammation. Over the years, zebrafish has proven to be a well-recognized model to study immune responses linked to human physiopathology. We here provide a systematic review of the molecular effectors of inflammation known in this vertebrate and recapitulate their modes of action, as inferred from sterile or infection-based inflammatory models. We present a comprehensive analysis of their sequence, expression, and tissue distribution and summarize the tools that have been developed to study their function. We further highlight how these tools helped gain insights into the mechanisms of immune cell activation, induction, or resolution of inflammation, by uncovering downstream receptors and signaling pathways. These progresses pave the way for more refined models of inflammation, mimicking human diseases and enabling drug development using zebrafish models.

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“…Cytokines exert a complicated influence on hematopoietic output; however, the actual effects of cytokines tend to be dose-dependent and time-dependent. The dose and acute or chronic exposure may bring opposite influences ( 53 , 54 , 109 ), which has been observed in IL-1 ( 45 , 110 – 112 ), TNFα ( 109 ), IFNs, and TGF-β ( Table 2 ). Besides the direct influence on HSCs, specific cytokines can also interfere with the normal signals controlling hematopoietic output downstream of stem cells.…”

Section: Negative Influences Of Inflammation On Hscsmentioning

confidence: 99%

Inflammatory abrasion of hematopoietic stem cells: a candidate clue for the post-CAR-T hematotoxicity?

Sun

Huang

et al. 2023

Front. Immunol.

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Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable effects in treating various hematological malignancies. However, hematotoxicity, specifically neutropenia, thrombocytopenia, and anemia, poses a serious threat to patient prognosis and remains a less focused adverse effect of CAR-T therapy. The mechanism underlying lasting or recurring late-phase hematotoxicity, long after the influence of lymphodepletion therapy and cytokine release syndrome (CRS), remains elusive. In this review, we summarize the current clinical studies on CAR-T late hematotoxicity to clarify its definition, incidence, characteristics, risk factors, and interventions. Owing to the effectiveness of transfusing hematopoietic stem cells (HSCs) in rescuing severe CAR-T late hematotoxicity and the unignorable role of inflammation in CAR-T therapy, this review also discusses possible mechanisms of the harmful influence of inflammation on HSCs, including inflammatory abrasion of the number and the function of HSCs. We also discuss chronic and acute inflammation. Cytokines, cellular immunity, and niche factors likely to be disturbed in CAR-T therapy are highlighted factors with possible contributions to post-CAR-T hematotoxicity.

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Macrophage-Derived IL-1β Regulates Emergency Myelopoiesis via the NF-κB and C/ebpβ in Zebrafish

Cited by 9 publications

References 52 publications

Zebrafish: a convenient tool for myelopoiesis research

Zebrafish: a convenient tool for myelopoiesis research

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

Inflammatory abrasion of hematopoietic stem cells: a candidate clue for the post-CAR-T hematotoxicity?

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