Macromolecular Colloids of Diblock Poly(amino acids) That Bind Insulin

Self‐assembly and responsiveness of polypeptide‐based block copolymers: How “Smart” behavior and topological complexity yield unique assembly in aqueous media

“…In general, the helical, rod-like nature of the peptide results in a flatter interface, which favors vesicle of fibril formation. [77][78][79][80][81][82][83][84][85] FIGURE 5 R h vs. pH plots for PB 107 [83][84][85] In their research, they studied assemblies formed from poly(c-benzyl-L-glutamate) 23 -b-hyaluronan 10 (PBLG 23 -b-HYA 10 , polypeptide-bpolysaccharide) polysaccharide. They denote that the PBLG block was chosen to guarantee the formation of vesicles, whereby its rigid, helical nature leads to close packing of helices which serves to favor flatter interface morphologies (Fig.…”

“…81,86 Other reports in literature have shown vesicle formation for copolypeptide amphiphiles that contain two blocks of naturally occurring amino acids; one block being a rod-like, hydrophobic helix and the other a polyelectrolyte serving to stabilize the assembly through electrostatic interaction with water. 75,[78][79][80]82,87 Deming and coworkers have performed seminal work in this area, and the physical behavior of these vesicle-forming copolypeptides is well illustrated through their work. For example, they studied the aggregation behavior of PLys-b-poly(L-leucine) (PLys-b-PLLeu) copolymers; the PLeu was employed as due to its hydrophobicity and its ability to form stable helices.…”

Electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on Pt

“…Results have shown that insulin is more highly and more irreversibly adsorbed to a hydrophobic methylated silica surface than to a hydrophilic silica surface [9]. Recently, potential new delivery systems for insulin based on the reversibility of an insulin-nanoparticle complex have been reported [10][11][12]. The adsorption of insulin is also important in the design of the artificial pancreas since the enzymatic activity of insulin must be retained when adsorbed onto surfaces [13].…”

Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide)-g-poly(vinylpyrrolidone): Association behavior in aqueous solution and interaction with anionic surfactants

“…These copolymers are commercially available for many technical applications as Poloxamer or Pluronic with a variety of PPO/PEO ratios and molecular weights [1,2]. The amphiphilic property of the block copolymers leads to selfassembly behavior resembling that of low molecular weight surfactants [3][4][5][6]. Temperature-dependent micellization is one of the most characteristic properties of aqueous PEO-PPO-PEO block copolymer solutions [7][8][9][10].…”