Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide)-g-poly(vinylpyrrolidone): Association behavior in aqueous solution and interaction with anionic surfactants

Zhang, Y.; Lam, Yeng Ming; Tan, Wen See

doi:10.1016/j.jcis.2004.12.033

Cited by 45 publications

(29 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, when micellization occurs, high ΔS°values are observed in relation to the isolated PL F-127, reflecting the formation of a mixed system. 30,31 In addition to DSC analysis, other information about micelles, such as their micellar hydrodynamic diameter, is presented in the Supporting Information.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Pluronics F-127/L-81 Binary Hydrogels as Drug-Delivery Systems: Influence of Physicochemical Aspects on Release Kinetics and Cytotoxicity

et al. 2014

View full text Add to dashboard Cite

We investigated the structure of the binary mixture of Pluronic F-127 (PL F-127) and Pluronic L-81 (PL L-81), as hydrogels for sumatriptan delivery and investigated the mixture possible use via subcutaneous route for future applications as a long-acting antimigraine formulation. We studied the drug-micelle interaction by dynamic light scattering and differential scanning calorimetry, sol-gel process by rheology, and small-angle X-ray scattering (SAXS). We also employed pharmaceutical formulation aspects by dissolution rate, release profile, and cytotoxicity studies for apoptosis and/or necrosis in fibroblasts (3T3) and neural cells (Neuro 2a). Micellar hydrodynamic diameter studies revealed the formation of binary PL-micelles by association of PL F-127/PL L-81. The mixed micelle and binary hydrogels formation was also verified by only one phase transition temperature for all formulations, even in the presence of sumatriptan. The characterization of the hydrogel supramolecular organization by SAXS, rheology studies, and in vitro dissolution/release results showed a probable relationship between the transition of the lamellar to the hexagonal phase and the lower release constant values observed, indicating that PL L-81 participates in micelle-hydrogel formation and aggregation processes. Furthermore, the reduced cytotoxicity (annexin V-fluorescein isothiocyanate positive staining), with minor PL L-81 concentration, points to its potential use for the development of binary PL-systems containing sumatriptan capable of modulating the gelation process. This use may employ the minimum PL concentration and be interesting for pharmaceutical applications, particularly for migraine treatment.

show abstract

Section: ■ Experimental Sectionmentioning

confidence: 99%

Pluronics F-127/L-81 Binary Hydrogels as Drug-Delivery Systems: Influence of Physicochemical Aspects on Release Kinetics and Cytotoxicity

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Amphiphilic block or graft copolymers containing hydrophilic and hydrophobic segments have the ability of micellization by self‐assembly in selective solvents [1–6]. In recent years, various amphiphilic polymers have been widely investigated because of their special physical chemical properties and novel morphologies, (e.g., spherical structure, rod particles, and necklace‐like particles) [6, 7].…”

Section: Introductionmentioning

confidence: 99%

The synthesis of poly(vinyl cinnamates) and its self‐assembled structure

Liu

Zhang

et al. 2012

Polymer Engineering & Sci

View full text Add to dashboard Cite

Poly(vinyl cinnamates) (PVCi) with different degrees of substitution (DS) are synthesized by grafting p‐chloro‐substituted cinnamic acid onto poly(vinyl alcohol). The chemical structures of PVCi were confirmed by 1H NMR. Amphiphilic PVCi copolymers were self‐assembled into particles in a selective solvent. The morphology and diameter of particles have been studied by scanning electron microscopic and dynamic light scattering. The morphology and hydrodynamic diameter have strong relationship with DS and water content introduced during self‐assembly process. The prepared PVCi could photo‐cross‐link at λ = 360 nm due to the photodimerization between pendant cinnamate groups. However, the self‐assembled PVCi particles did not present photo‐crosslinking behavior. The formed regular particles could disperse in aqueous solution, which increases their applications in biomedical fields. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers

show abstract

“…This justifies the broader endothermic peak and the minor enthalpy variations observed during the micellization process for the binary systems. [30][31][32][33] Moreover, comparisons among PL 407 and its binary systems with PL 188 showed an increase in enthalpy variation values, possibly due to dehydration of units of the PPO micellar core that was induced by the presence of a hydrophilic drug such as TR hydrochloride into the PL 407-PL 188 systems.…”

mentioning

confidence: 99%

Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

Santos¹,

Akkari²,

Ferreira³

et al. 2015

IJN

View full text Add to dashboard Cite

In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407–PL 188 hydrogels containing tramadol (TR) to analyze its potential treatment of acute pain. Drug–micelle interaction studies showed the formation of PL 407–PL 188 binary systems and the drug partitioning into the micelles. Characterization of the sol-gel transition phase showed an increase on enthalpy variation values that were induced by the presence of TR hydrochloride within the PL 407 or PL 407–PL 188 systems. Hydrogel dissolution occurred rapidly, with approximately 30%–45% of the gel dissolved, reaching ~80%–90% up to 24 hours. For in vitro release assays, formulations followed the diffusion Higuchi model and lower K rel values were observed for PL 407 (20%, K rel =112.9±10.6 μg·h −1/2 ) and its binary systems PL 407–PL 188 (25%–5% and 25%–10%, K rel =80.8±6.1 and 103.4±8.3 μg·h −1/2 , respectively) in relation to TR solution (K rel =417.9±47.5 μg·h −1/2 , P <0.001). In addition, the reduced cytotoxicity (V79 fibroblasts and hepatocytes) and genotoxicity (V79 fibroblasts), as well as the prolonged analgesic effects (>72 hours) pointed to PL-based hydrogels as a potential treatment, by subcutaneous injection, for acute pain.

show abstract

Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide)-g-poly(vinylpyrrolidone): Association behavior in aqueous solution and interaction with anionic surfactants

Cited by 45 publications

References 25 publications

Pluronics F-127/L-81 Binary Hydrogels as Drug-Delivery Systems: Influence of Physicochemical Aspects on Release Kinetics and Cytotoxicity

Pluronics F-127/L-81 Binary Hydrogels as Drug-Delivery Systems: Influence of Physicochemical Aspects on Release Kinetics and Cytotoxicity

The synthesis of poly(vinyl cinnamates) and its self‐assembled structure

Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

Contact Info

Product

Resources

About