Background: Discerning the determinants of weight loss maintenance is important in the planning of future interventions and policies regarding overweight and obesity. We have therefore systematically synthesized recent literature on determinants of weight loss maintenance for individuals with overweight and obesity.Methods: With the use of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, prospective studies were identified from searches in PubMed and PsycINFO from 2006 to 2016. We included articles investigating adults with overweight and obesity undergoing weight loss without surgery or medication. Included articles were scored on their methodological quality, and a best-evidence synthesis was applied to summarize the results.Results: Our search resulted in 8,222 articles of which 67 articles were selected. In total, 124 determinants were identified of which 5 were demographic, 59 were behavioural, 51 were psychological/cognitive and 9 were social and physical environmental determinants. We found consistent evidence that demographic determinants were not predictive of weight loss maintenance. Behavioural and cognitive determinants that promote a reduction in energy intake, an increase in energy expenditure and monitoring of this balance are predictive determinants.Conclusion: This review identifies key determinants in weight loss maintenance.However, more research regarding cognitive and environmental determinants of weight loss maintenance is needed to advance our knowledge on determinants of weight loss maintenance.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Participants with acute or chronic disease unable to undergo a weight loss trial. Participants who are using medication to lose weight. Participants who are pregnant or lactating.
InterventionExperimental study where long-term weight loss is followed by ≥1-year post-intervention. Experimental study where weight loss maintenance is conducted for ≥1 year from baseline. Observational study where participants have been followed up ≥1 year. Cross-sectional study. Qualitative study. Outcome Determinant analysed for effect on weight. Long-term weight loss: Weight change (kg), percent weight change (%), BMI change (kg m À2 ) from end of study to follow-up. Weight loss maintenance study: Weight change (kg), percent weight change (%), BMI change (kg m À2 ) from baseline to follow-up. Observational study: Maintenance vs. regain, where maintenance is defined as 5% weight loss for >1 year. Demographic, behavioural, psychological/cognitive, environmental (social and physical) determinants.