Lyotropic Liquid Crystal Phases of Phospholipids as Model Tools in Molecular Biophysics and Pharmacology

Lisetski, L. N.; Vashchenko, O. V.; Kasian, N. A.; Sviechnikova, Liliia V.

doi:10.1007/978-3-030-80924-9_4

Cited by 4 publications

(4 citation statements)

References 118 publications

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“…The presence of additional compounds could impact all these processes as well to shift equilibrium drug distribution between water and lipid phases. Indeed, there is a wide diversity of joint membranotropic effects caused both by API combinations [34] and by excipients in drug formulations [35]. Based on the above, we could interpret the results obtained in biopharmaceutical experiments.…”

Section: Discussionmentioning

confidence: 76%

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Рубан

Zupanets

Kolisnyk

et al. 2022

SR: PS

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The aim. Experimental selection of paracetamol and N-acetyl-D-glucosamine (NAG) ratio and combined dose and bioavailability study of the pharmaceutical composition and active pharmaceutical ingredient (API) in the model of cell biomembranes. Materials and methods. The following substances were used: paracetamol, Actimask Acetaminophen (gelatin-coated paracetamol), and NAG. For pharmacological studies were used laboratory rats, which received test objects intragastrically. The study was performed on the model of inflammatory hyperalgesia according to the Randall-Selitto method. The values of pain threshold before and after pathology induction were established. For biopharmaceutical studies, dry L-α-dimyristoylphosphatidylcholine purchased from Avanti Polar Lipids (purity 99.9 %) was used, hydrated with an appropriate amount of double-distilled water to obtain 70 % wt./wt. water dispersion. Differential scanning calorimetry (DSC) studies were performed employing DSC 1 microcalorimeter (Mettler Toledo). Pharmaceuticals investigated were placed on the bottom of a crucible, then a proper amount of the lipid membrane was added and this moment was taken as the time reference point (t=0). Then a crucible was sealed with a lid and a sample was undergone consecutive temperature scans, heating from 0 to 35 ºC at a scanning rate of 2 ºC/min. The procedure was repeated until no more changes in DSC profiles were observed, i.e. system equilibrium was reached. Results. It has been experimentally proven that the combination of paracetamol and NAG in the ratio of 4:1 showed better analgesic efficacy. The dose of active ingredients was determined to be 50 mg/kg by the sum of API. The active interaction of paracetamol with the bilayer of biomembranes was established and it was determined that Actimask has a worse rate of penetration into the membrane due to the coating of paracetamol with a gelatin shell. NAG didn't significantly affect the rate of penetration of Actimask through the bilayer of membranes, but the auxiliary components of the tablet mixture significantly improved the rate and completeness of penetration of paracetamol through the bilayer of biomembranes. Conclusions. The study found the most effective ratio between paracetamol and NAG in the composition, which is 4:1. The next step was to determine the dose of API, which is 50 mg/kg of the sum of active substances. It has been determined that paracetamol has good permeability through the bilayer of biomembranes, and the tablet mass significantly improves the permeability of paracetamol

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Section: Discussionmentioning

confidence: 76%

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Рубан

Zupanets

Kolisnyk

et al. 2022

SR: PS

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“…Amphotropic LCs that show both thermotropic and lyotropic phases were also identified [12,13]. For example, exhibition of amphotropic LC properties has been reported for many amino acid, peptide, phospho-and glycolipid-based LCs, with a special attention to the LC-like structure of cell membranes [14][15][16]. The properties of polymeric and elastomeric LC phases were also discussed [17][18][19][20].…”

Section: Types Of Liquid Crystalsmentioning

confidence: 99%

“…In the cholesteric (chiral nematic) LC phase, the director shows a helical structure and the molecules are arranged along a director axis with continuous changes of their directions in the form of a helix [28]. The helical period is typically in the range from 0.1 to 100 microns, with characteristics optimal for applications observed in more narrow ranges (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) µm in most cases). The more complex LC phases such as chiral nematic, chiral smectic, blue phases, and twist grain boundary phases were also identified [13], as well as most novel twist-bend and ferroelectric nematics [31,32].…”

Section: Thermotropic Liquid Crystalsmentioning

confidence: 99%

“…to 100 microns, with characteristics optimal for applications observed in more narrow ranges (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) µm in most cases). The more complex LC phases such as chiral nematic, chiral smectic, blue phases, and twist grain boundary phases were also identified [13], as well as most novel twist-bend and ferroelectric nematics [31,32].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

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Effects of Dispersed Carbon Nanotubes and Emerging Supramolecular Structures on Phase Transitions in Liquid Crystals: Physico-Chemical Aspects

Lisetski

Bulavin

Lebovka

2023

Liquids

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The current state of the study of different liquid crystalline (LC) systems doped with carbon nanotubes (CNTs) is discussed. An attempt is endeavored to outline the state-of-the-art technology that has emerged after two past decades. Systematization and analysis are presented for the integration of single- and multi-walled carbon nanotubes in thermotropic (nematic, smectic, cholesteric, ferroelectric, etc.) and lyotropic LCs. Special attention is paid to the effects of alignment and supramolecular organization resulting from orientational coupling between CNTs and the LC matrix. The effects of the specific inter-molecular and inter-particle interactions and intriguing microstructural, electromagnetic, percolation, optical, and electro-optical properties are also discussed.

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Functional nanoparticles for biomedical applications: a dsc study of membranotropic behavior

2021

Funct.Mater.

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Lyotropic Liquid Crystal Phases of Phospholipids as Model Tools in Molecular Biophysics and Pharmacology

Cited by 4 publications

References 118 publications

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Effects of Dispersed Carbon Nanotubes and Emerging Supramolecular Structures on Phase Transitions in Liquid Crystals: Physico-Chemical Aspects

Functional nanoparticles for biomedical applications: a dsc study of membranotropic behavior

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