Lymphoeitholioma-like carcinoma of the lung

Wöckel, W; Höfler, Gerald; Popper, Helmut; Morresi, Anna

doi:10.1016/s0344-0338(11)80665-5

Cited by 30 publications

(20 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That is the reason that some other reports have speculated about EBV presence as coincidental, due to the high prevalence of EBV infections in the general population. 10 However, it must be stressed that virus particles should be detected mostly in passenger lymphoid cells in normal population and not in epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…It is defined as an undifferentiated carcinoma that shows a typical syncytial growth pattern of undifferentiated neoplastic epithelial cells, with vesicular nuclei and prominent nucleoli, similar to the nasopharynx counterpart. 5 Primary lymphoepithelioma-like carcinoma of the lung is very rare and most of reports come from Chinese or Taiwanese patients, [6][7][8] and to date the association of EBV with these kind of lung carcinomas is restricted to Asian patients 9,10 (Table 1).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Epstein–Barr virus-associated adenocarcinomas and squamous-cell lung carcinomas

et al. 2009

View full text Add to dashboard Cite

The association of Epstein-Barr virus with pulmonary neoplasms has been restricted to lymphoepithelioma-like carcinomas in Asian patients. We have selected 19 pulmonary adenocarcinomas and squamous-cell carcinomas from 1545 pulmonary neoplasms diagnosed from 1996 to 2007 in an occidental population. All of them showed a low-power appearance confusing between an epithelial and a lymphoid neoplasm, with a dense lymphocytic infiltrate intermingled with neoplastic cells giving an image akin to lymphoepithelial complexes. Five carcinomas presented typical features of Lymphoepithelioma-like lung carcinomas; but six cases could be classified as squamous-cell carcinomas and eight as adenocarcinomas. A semiquantitative polymerase chain reaction method, Early RNA genes 1 and 2 in situ hybridization as well as Latent membrane protein immunostaining for Epstein-Barr virus DNA, RNA and protein detection methods were used in every case. None of Lymphoepithelioma-like carcinomas showed positivity for Epstein-Barr virus in any used method. Otherwise four squamous-cell carcinomas and eight adenocarcinomas (12 cases) demonstrated viral sequences in polymerase chain reaction and/or in situ hybridization analysis in neoplastic cells. Moreover two adenocarcinomas also displayed human herpesvirus 6 DNA sequences coamplification in molecular analysis. Protein immunostaining was focally positive in only three cases. We performed the same analysis in 70 more cases of conventional pulmonary squamous-cell carcinomas and adenocarcinomas that gave negative results. In conclusion, a subset of pulmonary squamous-cell carcinomas and adenocarcinomas show Epstein-Barr DNA and/or RNA sequences in neoplastic cells. This finding expands the spectra of epithelial cell common tumours Epstein-Barr virus associated.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Epstein–Barr virus-associated adenocarcinomas and squamous-cell lung carcinomas

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The probe used was an antisense probe to internal repeat 1 region of the EBV genome, labelled with digoxigenin-11-uridine diphosphate (UDP). Details of the technique have been described previously [10].…”

Section: Casementioning

confidence: 99%

“…mL -1 total cell count, 28% Ly, 70% AM, 1% Ne, 0.3% eosinophils (Eo)) and EBV-deoxyribonucleic acid (DNA) was detected in BAL-fluid. Detection of EBVrelated small messenger ribonucleic acid (RNA) (EBER 1) and internal repeat region three of EBV genome were carried out as previously described [10,11]. A lymphocyte transformation test with T-and B-cell mitogens showed a completely normal response to stimulation.…”

Section: Casementioning

confidence: 99%

Chronic interstitial lung disease due to Epstein-Barr virus infection in two infants

Pfleger¹,

Eber²,

Popper³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

This case study reports on two infants, 5 and 6 months of age, respectively, with chronic interstitial lung disease who presented with failure to thrive, tachypnoea, rales and mild hypoxaemia.Epstein-Barr virus (EBV) was detected by in situ hybridization in lung biopsy specimens and by EBV-deoxyribonucleic acid-polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) fluid in one patient and by in situ hybridization and PCR analysis in BAL fluid in the second patient. There was serological evidence of immunoglobulin G antibodies to EBV capsid antigen by indirect immunofluorescence in both patients.After 7 months of respiratory symptoms one patient was successfully treated with a 10 day course of intravenous ganciclovir followed by oral acyclovir for 20 days. The other patient became symptom free after 3.5 months of respiratory symptoms, without any specific antiviral medication. During a follow-up of 2 and 1.5 yrs, respectively, both infants remained symptom free and showed normal physical development. Eur Respir J 2000; 15: 803±806.

show abstract

“…Pulmonary lymphoepithelioma-like carcinoma (LELC), first described by Begin et al in 1987 (1), has been recognized as a rare but distinctive histologic variant among undifferentiated carcinomas (2)(3)(4)(5)(6), histologically identical to lymphoepithelial carcinomas arising in the nasopharynx and in other anatomic sites (7)(8)(9)(10). Of particular interest is the close association between Epstein-Barr virus (EBV) infection and the occurrence of pulmonary LELC in Asian and related ethnic populations (5).…”

Section: Introductionmentioning

confidence: 99%