Pulmonary Lymphoepithelioma-like Carcinoma: Predominant Infiltration of Tumor-associated Cytotoxic T Lymphocytes Might Represent the Enhanced Tumor Immunity

Kobayashi, Motohiro; Ito, Makoto; Sakai, Kenji; Honda, Takayuki; Nakayama, Jun

doi:10.2169/internalmedicine.43.323

Cited by 27 publications

(13 citation statements)

References 11 publications

(20 reference statements)

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“…Currently, there have been 33 case reports and/or series describing the occurrence of LELC of the lung, 1–33 which are summarized in Table 1. The patients were predominantly East Asians, and Caucasians accounted for only 18 of 153 cases.…”

Section: Epidemiologymentioning

confidence: 99%

“…Tumour‐infiltrating lymphocytes have been shown to be predominantly CD8‐positive and T cell intracytoplasmic antigen (TIA‐1)‐positive cytotoxic T cells 31 . The negative expression of granzyme‐B in these tumour‐infiltrating T lymphocytes may indicate that the cytotoxic T lymphocytes are in a resting state, possibly because of inhibition by local immunosuppressive factors in the tumour environment 25 .…”

Section: Pathologymentioning

confidence: 99%

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Lymphoepithelioma‐like carcinoma of the lung

Ho¹,

Wong

Lam³

2006

Respirology

108

131

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Lymphoepithelioma-like carcinoma of the lung HO JC, WONG MP, LAM WK. Respirology 2006; 11: 539-545 Abstract: Lymphoepithelioma-like carcinoma (LELC) of the lung was first reported in 1987. In the past two decades, there have been just more than 150 cases reported in the literature. This uncommon but distinct form of non-small cell lung carcinoma has a predilection for young non-smoking Asians, without gender distinction. Histologically, it is indistinguishable from undifferentiated nasopharyngeal carcinoma. The carcinogenic role of latent Epstein-Barr virus infection in causing LELC of the lung has been evident almost exclusively in Asians compared with Caucasians. Among the reported cases, more than half were in early resectable stages (I or II) and there was a tendency for peribronchovascular spread with vascular encasement in advanced diseases. In order to establish the diagnosis of LELC of the lung, both nasopharyngeal carcinoma and lymphoma have to be excluded by endoscopic biopsy (with or without magnetic resonance imaging of the nasopharynx) and immunohistochemical staining of the biopsy samples. The mainstay of treatment for early-stage disease is curative surgical resection, whereas multimodality treatment (surgery, chemotherapy, radiotherapy) has been adopted in advanced or metastatic diseases. The overall survival is more favourable in LELC of the lung compared with non-LELC type of non-small cell lung carcinoma. Future collaborative studies especially on optimizing treatment for this uncommon malignancy are clearly warranted.

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Section: Epidemiologymentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

Lymphoepithelioma‐like carcinoma of the lung

Ho¹,

Wong

Lam³

2006

Respirology

108

131

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“…Moreover, their reduced response in the tumor tissue may be due to the suppressive influence under the tumor microenvironment. In this context, TIL have been identified in numerous neoplasia, such as melanoma [5-9], various carcinomas [10-17], myeloma [18], pediatric tumors [19] and sarcomas [20-22] and the therapeutic relevance of these TIL has been also documented in both animal models and clinical trials [23-28]. Unfortunatly, up to date, very few data is available on the phenotypic and functional characterization of TIL isolated from adult bone-associated tumors.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and functional analysis of lymphocytes infiltrating osteolytic tumors: use as a possible therapeutic approach of osteosarcoma

et al. 2005

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Background: Osteosarcoma is the most common type of primary bone tumor. The use of aggressive chemotherapy has drastically improved the prognosis of the patients with nonmetastatic osteosarcomas, however the prognosis of the patients with metastasis is still very poor. Then, new and more effective treatments for curing osteosarcoma, such as immunotherapy are needed. Tumor-infiltrating lymphocytes (TIL) have been involved in the control of tumor development and already assessed with success for the treatment of several cancers including melanoma. While TIL represent a fascinating therapeutic approach in numerous malignant pathologies, there is few report concerning adult bone-associated tumors including osteosarcoma.

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“…In particular, some cases of LELC showed prominent infiltration of CD8 1 cells among the T-cell population. [15][16][17] Moreover, some studies have revealed an increasing number of S-100epositive dendritic cells, 11,[18][19][20][21] and factor XIIIaepositive cells 3,22 were scattered throughout the tumor cell nests. Factor XIIIa, a coagulation transglutaminase, is a cytoplasmic marker for dermal dendritic cells.…”

Section: Discussionmentioning

confidence: 99%