“…The latter is quite often represented by a mediastinal tumour in the thymic region, with the same anatomical features described by Sternberg in 1915. Quite often, however, the leukaemic manifestation develops after the appearance of the ML, usually within six months from onset, with high WBC count, a high incidence of early CNS involvement (Greenberg et al, 1976), and a poor prognosis (Catovsky et al, 1974b;Sen and Borella, 1975;Belpomme et al, 1977), particularly in males (Hann et al, 1977). The distinction between leukaemia and lymphoma, based on the presence of marrow involvement at diagnosis, was not of prognostic significance in one reported series (Coccia et al, 1976).…”