Subset derivation of T-cell acute lymphoblastic leukemia in man.

Reinherz, Ellis L.; Nadler, Lee M.; Sallan, Stephen E.; Schlossman, Stuart F.

doi:10.1172/jci109474

Cited by 63 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, Bi appears to be a B cell differentiation antigen present throughout most stages of B cell maturation. Similarly, a number of anti-T cell antibodies have been described that are capable of dissecting normal intraand extrathymic maturation (47), as well as defining distinct subsets of clinically relevant malignant T cell leukemias and lymphomas (31,32,38,48,49).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

et al. 1981

Self Cite

View full text Add to dashboard Cite

A B S T R A C T A monoclonal antibody (anti-B 1) specific for a unique B cell surface differentiation antigen was used to characterize the malignant cells from patients with leukemias or lymphomas. All tumor cells from patients with lymphomas or chronic lymphocytic leukemias, bearing either monoclonal K or X light chain, expressed the Bl antigen. In contrast, tumor cells from T cell leukemias and lymphomas or acute myeloblastic leukemias were unreactive. Approximately 50% of acute lymphoblastic leukemias (ALL) of non-T origin and 50% of chronic myelocytic leukemia in blast crisis were also anti-Bl reactive. Moreover, 21 of 28 patients with the common ALL antigen (CALLA) positive form of ALL were anti-B1 positive, whereas 0 of 13 patients with CALLA negative ALL were reactive.These observations demonstrate that an antigen present on normal B cells is expressed on the vast majority of B cell lymphomas and on -75% of CALLA positive ALL, suggesting that these tuimors may share a common B cell lineage.

show abstract

Section: Resultsmentioning

confidence: 99%

“…clonal antibodies and heteroantiserum, and these tumor cells were uniformly >20% erythrocyte rosette reactive (31,32 (33). These Ia-like antigens have not been detected on the vast majority ofT cell leukemias and lymphomas, but are expressed on most hematopoietic non-T cell malignancies.…”

Section: Methodsmentioning

confidence: 91%

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

et al. 1981

Self Cite

View full text Add to dashboard Cite

show abstract

“…In earlier studies with TH2 heteroantisera, approximately 20% of T-ALL tumor populations were TH2+ (20). These tumor populations were precisely the ones reactive with monoclonal antibodies defining stage II thymocytes.…”

mentioning

confidence: 87%

“…We show that three major stages of intrathymic differentiation exist and that the majority of tumor populations from patients with acute lymphoblastic leukemia of T-cell lineage (T-ALL) can be shown to These individual tumors had been determined to be of T-cell lineage by their spontaneous rosette formation with sheep erythrocytes (>20% E+) and their reactivity with T-cell-specific heteroantisera anti-HTL (B.K.) and A99, as described (9,20 (12,18,19,(21)(22)(23). In brief, these antibodies were shown to be restricted in their reactivity to cells of T lineage.…”

mentioning

confidence: 92%

“…As shown in Table 2 Surface Antigens Expressed by Leukemic Blasts of T Lineage. Because T-ALL is thought to be derived from immature thymocytes, it seemed important to determine whether tumor cells from individuals with T-ALL were related to any of these proposed stages of intrathymic differentiation (20). Consequently, 25 tumor-cell populations from individuals with T-ALL and three T-cell lines that had been studied with conventional anti-T cell reagents and E rosetting were investigated (19).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

Reinherz

Kung

Goldstein

et al. 1980

Proc. Natl. Acad. Sci. U.S.A.

1,423

438

View full text Add to dashboard Cite

A series of monoclonal antibodies was used to define three discrete stages of human intrathymic T-cell differentiation. The earliest stage was confined to <10% of thymocytes, which were.reactive with both OKT9 and OKT1O. Subsequently, approximately 70% of human thymocytes acquired a thymocyte-restricted antigen, OKT6, lost OKT9 antigen, and expressed reactivity with OKT4 and OKT5. These last two monoclonal antibodies were previously shown to define inducer (helper) and cytotoxic/suppressor populations, respectively, in peripheral blood. The OKT4+, OKT5+, OKT6+ "common" thymocyte population represents the majority of thymocytes and accounts for more than 70% of thymocytes. With further maturation, thymocytes lose OKT6 reactivity, segregate into OKT4+ and OKT5+ subsets, and acquire reactivity with OKT3 (and OKT1). This latter stage corresponds to the more functionally mature subset. The possible relationship of acute lymphoblastic leukemia of T-cell lineage to these proposed stages of intrathymic differentiation was determined. Analysis of25 tumor populations showed that 21 could be related to one or another differentiative stage. The majority (15/21) were derived from an early thymocyte or prothymocyte subpopulation, 5/25 were derived from a common thymocyte subpopulation, and 1/25 was derived from a mature (OKT3+) subpopulation. These data suggest that is it now possible to define stages of T-cell differentiation that can be related to T-cell malignancies in humans.The importance of a thymic microenvironment in the differentiation and functional maturation of T cells has been demonstrated in several species. Moreover, profound changes in cell-surface antigens mark the various stages of T-cell ontogeny (1-7). For (12). These thymcytes were the most functionally mature and probably ready for peripheral exportation. Human peripheral T cells also consist of functionally distinct subsets (13)(14)(15)(16)(17)(18)(19).In the present study, we used a series of monoclonal antibodies reactive selectively with subpopulations of human thymocytes and inducer and suppressor T-cell subsets in order to further define stages of thymic differentiation (18, 19). We show that three major stages of intrathymic differentiation exist and that the majority of tumor populations from patients with acute lymphoblastic leukemia of T-cell lineage (T-ALL) can be shown to

show abstract

Predictive ability of lukes-collins classification for immunologic phenotypes of childhood non-Hodgkin lymphoma: An institutional series and literature review

Crist

Kelly

Ragab

et al. 1981

Cancer

View full text Add to dashboard Cite

Tissues from 22 children with non-Hodgkin lymphoma (NHL) were studied pathologically and immunologically. Most children were noted to have marked (B- or T-cell) neoplasms and the Lukes-Collins classification was predictive of immunologic phenotype in cases where markers were present. Our series and a review of the literature demonstrates that most abdominal NHL are B-cell in origin and are often small noncleaved follicular center cell lymphoma (Burkitt type). Most mediastinal primary lesions are T-cell in origin and of convoluted cell morphology. A few neoplasms (often peripheral nodal) lack the characteristic surface immunoglobulin or erythrocyte rosetting properties of B- or T-cell lesions, respectively. Frequently marrow and central nervous system involvement are observed in T-cell lymphomas and are not in frequent in B cell neoplasms. Shared immunologic and clinical features between the B- or T-cell lymphomas and their leukemic counterparts support the concept that they often differ only in the stage of disease progression.

show abstract

Subset derivation of T-cell acute lymphoblastic leukemia in man.

Cited by 63 publications

References 34 publications

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

A unique cell surface antigen identifying lymphoid malignancies of B cell origin.

Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

Predictive ability of lukes-collins classification for immunologic phenotypes of childhood non-Hodgkin lymphoma: An institutional series and literature review

Contact Info

Product

Resources

About