Lymphatic absorption from the peritoneal cavity: Regulation of patency of mesothelial stomata

Tsilibary, Effie-Photini C; Wissig, Steven L.

doi:10.1016/0026-2862(83)90041-9

Cited by 129 publications

(76 citation statements)

References 13 publications

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“…They represent discontinuities in the mesothelial lining, which is the main and rapid lymphatics drainage for the fluid, particles, and cells from the peritoneal, diaphragm, and pleural cavities to the submesothelial lymphatic lumen (Li and Yu, 1991;Abu-hijeh and Scothorne, 1994;Nakatani et al, 1997;Wang et al, 1997;Azzali, 1999;Li and Li, 2003). The data from our group and others indicate that the opening area of lymphatic stomata varies under the different fluid pressure, mechanical forces, and Chinese meteria medica (Tsilibary and Wissig, 1983;Miserocchi et al, 1989;Li et al, 1996). Moreover, we found that nitric oxide, vascular endothelial growth factor and angioteinsin II can enhance the lymphatic absorption on the pleural and pericardial lymphatic stomata by enlarging lymphatic stomata (Li et al, 2001;Li and Li, 2004).…”

mentioning

confidence: 63%

Ultrastructure and Estrogen Regulation of the Lymphatic Stomata of Ovarian Bursa in Mice

Zhou

Gao

et al. 2007

The Anatomical Record

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The ovarian bursa is a key player in maintaining adaptive ovarian microenvironment for ovulation. The lymphatic stomata are believed to be a major contributor to execute the function of the ovarian bursa, whereas little is known about their ultrastructure and regulation. Here, we examined the ultrastructure of lymphatic stomata in mouse ovarian bursa by scanning electron microscopy and transmission electron microscopy and investigated its regulation by estrogen. We found that the mesothelium on the visceral layer of mouse ovarian bursa was composed of the cuboidal and flattened cells. The lymphatic stomata with round and oval shapes were mainly among the cuboidal cells. The particles, cells, and fluid passed through the stomata and entered into the lymphatic drainage unit composed of connective tissue and lymphatic endothelial cells beneath the stomata. We also used trypan blue as a tracer and found that the absorption of trypan blue through the lymphatic stomata was increased by estrogen that enlarged the average opening area of lymphatic stomata. Furthermore, we detected that there existed estrogen receptors in the nuclei of the mesothelial cells on the visceral ovarian bursa by using immunoelectron microscopy. Taken together, these data suggest that both the absorption and opening area of the lymphatic stomata in mouse ovarian bursa may be influenced by estrogen.

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mentioning

confidence: 63%

Ultrastructure and Estrogen Regulation of the Lymphatic Stomata of Ovarian Bursa in Mice

Zhou

Gao

et al. 2007

The Anatomical Record

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“…a; thoracic duct. the movement of the ink in the lymph vessels caused by gravity and the passive pressure generated by the thoracic musculature due to respiratory movement [3,8,10]. In quadrupeds such as dogs, if no other force affects lymphatic transport, the force of gravity would result in the accumulation of the injected India ink in the ventral peritoneal cavity, as well as drainage of the marker from the inside of the peritoneal cavity via the lymph vessels located along the internal thoracic artery of the ventral chest wall, since the movement of the marker in these lymph vessels is essentially promoted by gravity and passive pressure, such as muscular movement and respiratory movement [3,10].…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to the pressure of the liver on the right surface of the diaphragm. The uptake of lymph from the peritoneal side of the diaphragm's surface depends on the mesothelial cells of the diaphragm surface [1,2,5,8,9]. There may be more stomata located in the mesothelium on the surfaces with organ contact than on surfaces with no organ contact.…”

Section: Discussionmentioning

confidence: 99%

The Time Course of Lymph Drainage from the Peritoneal Cavity in Beagle Dogs

Shibata

Hiramatsu

Kaseda

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Lymph drainage routes from the abdominal and pelvic cavities in beagle dogs were observed serially by following the time course of India ink administered intraperitoneally. Four systems of lymph drainage routes from the peritoneal cavity were observed in this study. The earliest drainage returned to the cranial mediastinal lymph nodes via the sternal lymph vessels; subsequently, the sternal lymph nodes located along the internal thoracic artery became involved. Then, a drainage route via the lymph vessel along the left vagus nerve was observed. The final drainage route flowed into the lateral lymph vessel through the thoracic duct located on the vertebra. These results show that India ink is absorbed from the peritoneal cavity, and that the lymph drainage first flows mainly towards the cranial mediastinal lymph nodes through the ventral lymphatic channels. Our serial observations suggest that, over time, the lymph drainage routes changed from the ventral abdominal to the dorsal thoracic lymphatic channels in the thorax. KEY WORDS: beagle dog, lymph drainage, peritoneal cavity.J. Vet. Med. Sci. 68(11): 1143-1147, 2006 The lymphatic system establishes a lymphatic circulation and transports lymph containing lipid droplets, immunocytes, and tumor cells. Ultimately, lymphatic drainage routes flow into the systemic circulation. However, parts of the lymphatic system are located in serous cavities. These lymphatic routes have yet to be adequately clarified. Previously, a limited amount of information about the lymphatic drainage from the abdominal cavity was collected by examining the route that drains lymph from the canine peritoneal cavity [6]. Tracing marker administered into the peritoneal cavity was found to travel via the diaphragm to the sternal lymphatics located in the ventral inner-wall of the thoracic cavity. Subsequently, the same drainage pattern was observed in many animals [4,7,9]. This lymphatic drainage route may be clinically useful in predicting the course of intraperitoneal cancer dissemination. The present paper provides a detailed description of lymph drainage routes over time following the intraperitoneal administration of India ink in beagle dogs. MATERIALS AND METHODSThree adult male beagle dogs (body weight, 8.5 kg) and one adult female beagle dog (body weight, 6.7 kg) were used for this experiment.Using a fine needle, the male dogs were all injected intraperitoneally with warm India ink dissolved in physiological saline at a dose of 25 ml per kg body weight; the India ink was injected into the pelvic cavity via the rectum in the female dog. The male dogs were sacrificed by an overdose of Nembutal (0.2 ml/kg) at 30 min, 60 min, and 2.5 hr after ink injection, respectively. The female dog was sacrificed at 2.5 hr. A fixative solution [24 (ethylene glycol): 8 (phenol): 1 (formaldehyde solution): 16 (methanol)] was immediately injected intraperitoneally and intrapelvically after the animals were sacrificed. The peritoneal and pelvic cavities were dissected from the carcasses, and these ...

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“…plus pneumothorax to minimize diaphragmatic tension, (2) long lasting pharmacologically induced muscular contraction (carbacol choline 0-3 mg/kg, i.v. ; Tsilibary & Wissig, 1983). Specimens were then cut out from the tendinous region and processed for scanning electron microscopy.…”

Section: Pmentioning

confidence: 99%

Proceedings of the Physiological Society, 30 June‐ 1 July 1989, Oxford Meeting: Communications

1989

The Journal of Physiology

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Lymphatic absorption from the peritoneal cavity: Regulation of patency of mesothelial stomata

Cited by 129 publications

References 13 publications

Ultrastructure and Estrogen Regulation of the Lymphatic Stomata of Ovarian Bursa in Mice

Ultrastructure and Estrogen Regulation of the Lymphatic Stomata of Ovarian Bursa in Mice

The Time Course of Lymph Drainage from the Peritoneal Cavity in Beagle Dogs

Proceedings of the Physiological Society, 30 June‐ 1 July 1989, Oxford Meeting: Communications

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