Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease

Kapoor, Bhupinder; Gulati, Monica; Rani, Pooja; Kochhar, Rajpal Singh; Atanasov, A; Gupta, Rama; Sharma, Deepika; Kapoor, Deepak

doi:10.1002/biof.1910

Cited by 7 publications

(3 citation statements)

References 138 publications

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“…Lycopene is a lipophilic compound, which makes it easier to penetrate the blood-brain barrier. This may explain why it has the ability to prevent or treat a variety of neurological illnesses [123].…”

Section: Antioxidant Activity Of Lycopene In Nervous System Disordersmentioning

confidence: 99%

The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Kulawik,

Cielecka-Piontek,

Zalewski

2023

Nutrients

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Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect of lycopene is the result of its pleiotropic effect. The ability to neutralize free radicals via lycopene is one of the foundations of its pro-health effect, including the ability to inhibit the development of many civilization diseases. Therefore, this study focuses on the importance of the antioxidant effect of lycopene in inhibiting the development of diseases such as cardiovascular diseases, diseases within the nervous system, diabetes, liver diseases, and ulcerative colitis. According to the research mentioned, lycopene supplementation has significant promise for the treatment of illnesses marked by chronic inflammation and oxidative stress. However, the majority of the supporting data for lycopene′s health benefits comes from experimental research, whereas the evidence from clinical studies is both scarcer and less certain of any health benefits. Research on humans is still required to establish its effectiveness.

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Section: Antioxidant Activity Of Lycopene In Nervous System Disordersmentioning

confidence: 99%

The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Kulawik,

Cielecka-Piontek,

Zalewski

2023

Nutrients

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“…Different types of extracellular vesicles with specific proteins, lipid components and transcription enzymes have been extracted from various plants [ 6 , 7 ]. PLDEs can mediate cellular signaling [ 8 ], stimulate an immune response [ 9 ], transport substances between cells [ 10 ], and they connect unrelated species such as plants to parasites [ 11 ] as well as insects to plants [ 12 ]. Due to their diverse roles in regulating biological processes, PLDEs have found an additional role in clinical medicine, where they can act as therapeutic agents in the treatment of a variety of diseases including inflammation [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Therapeutic Applications of Plant-Derived Exosomes in the Treatment of Inflammatory Diseases

Wei

Zhang

et al. 2023

Biomedicines

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Plant-derived exosomes (PLDEs) are small extracellular vesicles that encapsulate proteins, nucleic acids and lipids, and they are usually involved in intercellular communication and molecular transport in plants. PLDEs are widely used in the therapy of diseases due to their abundance and easy availability. The diverse roles of PLDEs, which include transportation of drugs, acting as biomarkers for diagnosis of diseases and their roles in different therapies, suggest that there is a need to fully understand all the mechanisms involved in order to provide the optimum conditions for their therapeutic use. This review summarizes the biogenesis, components and functions of PLDEs and focuses on their use as therapeutic agents in the treatment of inflammatory diseases. It also explores new ideas for novel approaches in which PLDEs could potentially help patients with inflammatory diseases in the future.

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“…In photosynthetic organisms, carotenoids are the main antioxidants in the chloroplast to scavenge the toxic reactive oxygen species (ROS) generated by photosynthesis [2]. A variety of carotenoids, such as lycopene, β-carotene, lutein, and astaxanthin, are critical for human beings, largely because of their antioxidant activities [3,4]. For example, carotenoids are known to reduce the risk of a variety of age-related diseases, such as neurological disorders and macular degeneration [5].…”

Section: Introductionmentioning

confidence: 99%

Heterologous Production in the Synechocystis Chassis Suggests the Biosynthetic Pathway of Astaxanthin in Cyanobacteria

Liang,

Chen,

Liu

et al. 2023

Antioxidants

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Astaxanthin is a carotenoid species with the highest antioxidant capability. Its natural resource is very rare. The biosynthesis of astaxanthin from β-carotene includes a hydroxylation step and a ketolation step, for which the corresponding enzymes have been characterized in a few species. However, the sequence of these two reactions is unclear, and may vary with different organisms. In this study, we aimed to elucidate this sequence in Synechocystis, which is an ideal cyanobacterial synthetic biology chassis. We first silenced the endogenous carotene oxygenase gene SyneCrtO to avoid its possible interference in the carotenoid metabolic network. We then introduced the β-carotene ketolase gene from Haematococcus pluvialis (HpBKT) and the CrtZ-type carotene β-hydroxylase gene from Pantoea agglomerans (PaCrtZ) to this δCrtO strain. Our pigment analysis demonstrated that both the endogenous CrtR-type carotene hydroxylase SyneCrtR and HpBKT have the preference to use β-carotene as their substrate for hydroxylation and ketolation reactions to produce zeaxanthin and canthaxanthin, respectively. However, the endogenous SyneCrtR is not able to further catalyze the 3,3′-hydroxylation of canthaxanthin to generate astaxanthin. From our results, a higher accumulation of canthaxanthin and a much lower level of astaxanthin, as confirmed using liquid chromatography–tandem mass spectrometry analysis, were detected in our transgenic BKT+/CrtZ+/δCrtO cells. Therefore, we proposed that the bottleneck for the heterologous production of astaxanthin in Synechocystis might exist at the hydroxylation step, which requires a comprehensive screening or genetic engineering for the corresponding carotene hydroxylase to enable the industrial production of astaxanthin.

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Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease

Cited by 7 publications

References 138 publications

The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Advances in the Therapeutic Applications of Plant-Derived Exosomes in the Treatment of Inflammatory Diseases

Heterologous Production in the Synechocystis Chassis Suggests the Biosynthetic Pathway of Astaxanthin in Cyanobacteria

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