Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury

Çevik, Özge; Oba, Rabia; Macit, Çağlar; Çetınel, Şule; Kaya, Özlem; Şener, Emre; Şener, Göksel

doi:10.1016/j.burns.2012.01.006

Cited by 31 publications

(22 citation statements)

References 40 publications

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“…Evidence from animal and human studies suggested that there is a correlation between tissue MDA levels and the degree of burn complications, including shock and remote organ damage [29]. In this study, MDA levels were higher in the burn groups, especially on the 1 st day after thermal trauma.…”

Section: Discussionsupporting

confidence: 49%

The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns – Experimental Study Using a Rat Model of Thermal Trauma

Hoşnuter¹,

Melikoglu²,

Aslan³

et al. 2015

Adv Clin Exp Med

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Background. Epigallocatechin gallate (EGCG), a green tea polyphenol, has potent antioxidant properties. Objectives. The purpose of the present study was to examine the possible preventative effects of EGCG against internal organ injury due to large-surface skin burns in a rat model. Material and Methods. The study design involved three groups of rats: a sham group and two groups with 25-30% full-thickness burns: (a) the sham group without burns or treatment (n = 18); (b) the control burn group (burns + sterile saline, n = 18); and (c) the burn treatment group (burns + treatment with EGCG, n = 18). EGCG was administered intraperitoneally immediately after the thermal injury, and daily in 100 μmol/kg doses. Kidney and lung tissue samples were taken to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and glutathione peroxidase (GPX) after the first, third and seventh post-burn days. Results. In the EGCG-treated burn group, SOD and GPX activity were significantly higher than in the burn control group. Additionally, MDA and TNF-α levels were significantly lower in the EGCG-treated burn group. Conclusions. Based on this study, it might be anticipated that EGCG treatment may be beneficial in burn injury cases (Adv Clin Exp Med 2015, 24, 3, 409-417).

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Section: Discussionsupporting

confidence: 49%

The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns – Experimental Study Using a Rat Model of Thermal Trauma

Hoşnuter¹,

Melikoglu²,

Aslan³

et al. 2015

Adv Clin Exp Med

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show abstract

“…This carotenoid has many biochemical functions, some of which include it being an antioxidant scavenger, antihyperlipidemic agent and inhibitor of proinflammatory, as well as having prothrombotic factors [20] and antiapoptotic effects [21]. Recent experimental studies demonstrated that lycopene may act as a chemopreventive agent against certain types of cancers such as prostate cancer [18,19], in addition to the possibility of serving as a promising intervention to testicular toxicity associated with oxidative stress [9,18].…”

Section: Introductionmentioning

confidence: 98%

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Boeira

Funck

Filho

et al. 2015

Chemico-Biological Interactions

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“…Burn area greater than one-third of the total body surface area (TBSA) or full-thickness burn more than 10% of the total body surface area (TBSA) causes severe burn injury [1]. Severe skin thermal injury breaks the balance of the immune system which plays an important and complex role in the whole pathophysiologic process [2,3].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammative effect of glycyrrhizin on rat thermal injury via inhibition of high-mobility group box 1 protein

Shen

Cui

Lin

et al. 2015

Burns

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Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury

Cited by 31 publications

References 40 publications

The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns – Experimental Study Using a Rat Model of Thermal Trauma

The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns – Experimental Study Using a Rat Model of Thermal Trauma

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Anti-inflammative effect of glycyrrhizin on rat thermal injury via inhibition of high-mobility group box 1 protein

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