The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns – Experimental Study Using a Rat Model of Thermal Trauma

Abstract

Background. Epigallocatechin gallate (EGCG), a green tea polyphenol, has potent antioxidant properties. Objectives. The purpose of the present study was to examine the possible preventative effects of EGCG against internal organ injury due to large-surface skin burns in a rat model. Material and Methods. The study design involved three groups of rats: a sham group and two groups with 25-30% full-thickness burns: (a) the sham group without burns or treatment (n = 18); (b) the control burn group (burns + sterile saline, n = 18); and (c) the burn treatment group (burns + treatment with EGCG, n = 18). EGCG was administered intraperitoneally immediately after the thermal injury, and daily in 100 μmol/kg doses. Kidney and lung tissue samples were taken to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and glutathione peroxidase (GPX) after the first, third and seventh post-burn days. Results. In the EGCG-treated burn group, SOD and GPX activity were significantly higher than in the burn control group. Additionally, MDA and TNF-α levels were significantly lower in the EGCG-treated burn group. Conclusions. Based on this study, it might be anticipated that EGCG treatment may be beneficial in burn injury cases (Adv Clin Exp Med 2015, 24, 3, 409-417).

Wound Healing Properties of Green Tea Extract in Excision-Wounded Rats

“…These results are in line with the findings reported by Ali Akbar Abolfathi et al (2012) who observed that daily treatment with green tea extract markedly improved antioxidant status of liver tissue of rats with streptozotocin induced diabetes. Moreover in a burn model Hosnuter et al (2015), epigallocatechingallate (EGCG), exerted a potent antioxidant effect. In the EGCG-treated burn group, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were significantly higher than in the burn wounded control group.…”

Psalmotoxin-1 Venom on the Inflammatory Response and Burn Healing Process in the Experimental Burn Model

“…Post-recovery burn areas were evaluated by immunohistochemical staining. The aim here is to investigate the efficacy of the PcTx 1 venom, which we think accelerates the healing of various grades of burn injury after thermal injury [21] .…”

Contribution of Additional Glutamic Acid and Fructose in The Formation of Flavor Compounds in Green Tea

“…Tannins can precipitate proteins on cell surfaces and polyphenols, which have many health benefits because they have antioxidant activity with strength 100 times more effective than vitamin C and 25 times higher than vitamin E (Prastiwati et al, 2010). Additionally, EGCG is a polyphenol in green tea that possesses antiinflammatory, anti-microbial, and anti-allergic properties (Hosnuter et al, 2015).…”