Lycopene attenuates endothelial dysfunction in streptozotocin-induced diabetic rats by reducing oxidative stress

Zhu, Jianhua; Wang, Chunge; Yang, Xu

doi:10.3109/13880209.2011.574707

Cited by 47 publications

(47 citation statements)

References 22 publications

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“…In line with these findings, the beneficial role of taurine on diabetic vasculature was extensively evaluated by other experimental and clinical studies [99,100]. Zhu et al [101] investigated the rescue potential of lycopene, a potent antioxidant compound, in endothelial dysfunction by reducing the oxidative stress, hence indicating its use in preventing DVD associated with endothelial dysfunction.…”

Section: Role Of Antioxidants In Preventing Dvdmentioning

confidence: 62%

An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

Aditi¹,

Mahajan²,

Rawal³

et al. 2013

Pharm Anal Acta

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Section: Role Of Antioxidants In Preventing Dvdmentioning

confidence: 62%

An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

Aditi¹,

Mahajan²,

Rawal³

et al. 2013

Pharm Anal Acta

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“…Meanwhile, in human endothelial cells, lycopene prevents endothelin-1 expression by inhibiting ROS generation and inducing heme oxygenase-1 expression (HO-1) [44], while also inhibiting tumor necrosis factor (TNF)-α-induced NF-κB activation, ICAM-1 expression, and monocyte endothelial adhesion [15]. In an in vivo study, lycopene inhibited endothelial dysfunction in STZ-enhanced diabetic rats by lowering oxidative stress, which could have implications for the development of treatments to prevent diabetic vascular complications [16]. In addition, astaxanthin inhibits inflammation-induced inducible NO and ROS generation by suppressing NF-κB pathway activity in macrophages [45].…”

Section: Preventive Effects Of Carotenoids On Cardiovascular Disease mentioning

confidence: 99%

“…In streptozotocin (STZ)-induced diabetic rats, lycopene inhibited endothelial dysfunction [16]. However, the in vitro effects of dietary carotenoids do not always translate to an in vivo setting.…”

Section: Carotenoidsmentioning

confidence: 99%

Carotenoids Regulate Endothelial Functions and Reduce the Risk of Cardiovascular Disease

Yamagata¹

2017

Carotenoids

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Regular consumption of fruits and vegetables can help reduce the risk for cardiovascular disease (CVD) and its associated mortality. A diet rich in fruits and vegetables is thought to have cardioprotective effects, but the specific components of these foods that provide this protection are unclear. Antioxidants such as vitamin C, carotenoids, and polyphenols in fruits and vegetables likely contribute to the reduction in risk of CVD by minimizing cholesterol oxidation in blood vessel walls. Meanwhile, cardioprotective effects afforded by the carotenoids lycopene, α-carotene, β-carotene, β-cryptoxanthin, lutein, and zeaxanthin have been reported in many studies. Carotenoids are naturally occurring fat-soluble pigments that are present at high levels in tomatoes and carrots. Carotenoids play an important role in staving off atherosclerosis via antioxidant activities that reduce lipid peroxidation in low-density lipoproteins. Lycopene reduces endothelin-1 gene expression by suppressing generation of reactive oxygen species and inducing heme oxygenase-1 expression in human endothelial cells. Thus, carotenoids may mitigate endothelial dysfunction by promoting direct antioxidative effects and inducing expression of several genes. Structural and functional differences among carotenoids may explain their unique biologic activities. In this review, the roles of carotenoids in relation to their influence on vascular endothelial functions and cardioprotective effects are discussed.

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“…The BDL+L group was subjected to BDL and was treated with a suspension of 10 mg/kg body weight of lycopene (Sigma, St. Louis, MO, USA) in 0.5 mL of maize oil i.g. once daily, as described in a previous study (18). All treatments started 3 days before the operation and continued 7 days after the operation.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

Tokaç¹,

Aydın²,

Taner³

et al. 2015

Turk J Med Sci

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IntroductionMany clinical conditions, including strictures of the bile duct, gallstone complications of pancreatitis, or biliary surgery, are cited among etiologies that lead to a decrease in biliary flow, causing cholestasis (1). Cholestasis leads to acute hepatic injury and results in progressive fibrosis (2). The production of free oxygen radicals has been suggested to play an important role in the pathogenesis of cholestasis. One of the significant endpoints leading to liver damage arising from cholestasis is considered to be intrahepatic accumulation of toxic bile salts and inflammatory cells (3). A validated experimental model of acute cholestasis in rats can be presented by bile duct ligation (BDL) (4).Lipid peroxidation may result from the excessive production of reactive oxygen species (ROS), which may then interrupt the integrity of the cellular membranes and cause further hepatic injury in cholestasis (5-7). In cholestasis, the decline in the activity of glutathione peroxidase (GSH-Px), as well as the decline in reduced glutathione (GSH), may damage the antioxidant defense system (7). Altered gene expression and DNA base damage are the results of ROS; these may lead to the development of cancer and mutation (8).Useful effects of antioxidants in cholestasis have been reported in several experimental models (9). Being a natural antioxidant carotenoid, lycopene is suggested to be one of the most powerful antioxidants (10). Animal studies have indicated a large margin of safety for lycopene. An oral 90-day toxicity study in Wistar albino rats demonstrated the daily NOAEL of lycopene to be 586 Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods:The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated. Results:The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats. Conclusion:These results suggest that lycopene might have protective effects on acute cholestasis.

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Lycopene attenuates endothelial dysfunction in streptozotocin-induced diabetic rats by reducing oxidative stress

Cited by 47 publications

References 22 publications

An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

Carotenoids Regulate Endothelial Functions and Reduce the Risk of Cardiovascular Disease

Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

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