Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

Tokaç, Mehmet; Aydın, Sevtap; Taner, Gökçe; Özkardeş, Alper Bilal; Taşlıpınar, Mine Yavuz; Doğan, Mehmet; Dündar, Halit Ziya; Kılıç, Mehmet; Başaran, Arif Ahmet; Başaran, Ayşe

doi:10.3906/sag-1404-57

Cited by 19 publications

(3 citation statements)

References 43 publications

(54 reference statements)

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“…It reduced NO and MDA levels and improved reduced enzymatic level (i.e., CAT, GSTs, GSH, and SOD) in the BDL rat. In addition, lycopene decreased DNA damage [71].…”

Section: Hepatoprotectivementioning

confidence: 90%

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

et al. 2020

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Lycopene, belonging to the carotenoids, is a tetraterpene compound abundantly found in tomato and tomato-based products. It is fundamentally recognized as a potent antioxidant and a non-pro-vitamin A carotenoid. Lycopene has been found to be efficient in ameliorating cancer insurgences, diabetes mellitus, cardiac complications, oxidative stress-mediated malfunctions, inflammatory events, skin and bone diseases, hepatic, neural and reproductive disorders. This review summarizes information regarding its sources and uses amongst different societies, its biochemistry aspects, and the potential utilization of lycopene and possible mechanisms involved in alleviating the abovementioned disorders. Furthermore, future directions with the possible use of this nutraceutical against lifestyle-related disorders are emphasized. Its protective effects against recommended doses of toxic agents and toxicity and safety are also discussed.

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“…It reduced NO and MDA levels and improved reduced enzymatic level (i.e., CAT, GSTs, GSH, and SOD) in the BDL rat. In addition, lycopene decreased DNA damage [71].…”

Section: Hepatoprotectivementioning

confidence: 90%

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

et al. 2020

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“…In addition to CAT, which plays a vital role in decomposing H 2 O 2 into O 2 and H 2 O, GPx is a critical enzyme that catalyzes the reduction of H 2 O 2 (46,47). Increased GPx and SOD levels in liver tissue can decrease oxidative stress-mediated injury in cholestatic animal models (48,49). Our findings showed that OD therapy in BDL-induced cholestatic rats significantly promotes the functions of SOD and GPx in liver tissue.…”

Section: Discussionmentioning

confidence: 57%

Oliveria decumbens Extract Exhibits Hepatoprotective Effects Against Bile Duct Ligation-Induced Liver Injury in Rats by Reducing Oxidative Stress

et al. 2023

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Background: Cholestasis is described as a disease in which bile flow from the liver is reduced or stopped, and due to its oxidative effects, irreversible consequences may occur. Due to the remarkable antioxidant properties of Oliveria decumbens (OD) and the contribution of oxidants to the progression of bile duct ligation (BDL)-induced cholestasis, Objectives: This research aimed to examine how the OD ethanolic extract affected liver damage and oxidant-antioxidant balance markers in BDL-induced cholestasis. Methods: Forty male Wistar rats weighing 200 - 250 g were used. Cholestasis was induced using the BDL approach. The rats were categorized into four groups: Group 1, sham control (SC); group 2, cholestatic; group 3, SC + OD; and group 4, cholestatic + OD. A dose of OD ethanolic extract was administered orally (500 mg/kg/day) to rats for seven days. Seven days following surgery, the rats’ blood samples were collected; after sacrifice, a part of the liver tissue was isolated. A histopathological examination was performed, while the rest was stored at -70°C in liquid nitrogen. Heparin-containing tubes were used to gather blood samples. In plasma and hepatic tissue, biochemical tests, histopathological evaluations, and oxidative stress markers staining levels were performed. Results: Our findings showed that OD could effectively reduce liver injury by reducing the activity of liver function enzymes (AST and ALP). At the same time, it did not affect total bilirubin and protein. Bile duct ligation-induced hepatic markers of protein oxidation (PCO) and reactive nitrogen species (NO) were significantly decreased by OD, and it also promoted liver antioxidant capacity by enhancing superoxide dismutase (SOD) activities. Moreover, OD treatment prevented liver bile duct proliferative changes in histopathologic analysis. Conclusions: Our study confirmed that OD exerts substantial hepatoprotective activities against BDL-induced cholestasis by improving liver damage markers and regulating oxidative stress. It may be a beneficial therapeutic agent for managing cholestasis. Bioassay-guided isolation and identification of bioactive OD secondary metabolites can further direct the discovery of potential natural-based drug candidates.

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“…Recently, reversions of lycopene on liver fibrosis are further reported in rodent models of high-cholesterol/ HFD and HFD, respectively, which may be related to its antioxidant and anti-inflammatory effects, the increase of macrophage M2-dominant polarization, or the downregulation of FABP7 expression [276][277][278][279][280]. Lycopene also reverses BDL-induced rat liver injury by inhibiting oxidative stress and DNA damage [281].…”

Section: Lycopenementioning

confidence: 99%

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

Wang

Niu

et al. 2022

European Journal of Gastroenterology &Amp; Hepatology

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Liver fibrosis has a high incidence worldwide and is the common pathological basis of many chronic liver diseases. Liver fibrosis is caused by the excessive deposition of extracellular matrix and concomitant collagen accumulation in livers and can lead to the development of liver cirrhosis and even liver cancer. A large number of studies have provided evidence that liver fibrosis can be blocked or even reversed by appropriate medical interventions. However, the antifibrosis drugs with ideal clinical efficacy are still insufficient. The edible plant-derived natural compounds have been reported to exert effective antifibrotic effects with few side-effects, representing a kind of promising source for the treatment of liver fibrosis. In this article, we reviewed the current progress of the natural compounds derived from dietary plants in the treatment of liver fibrosis, including phenolic compounds (capsaicin, chlorogenic acid, curcumin, ellagic acid, epigallocatechin-3-gallate, resveratrol, sinapic acid, syringic acid, vanillic acid and vitamin E), flavonoid compounds (genistein, hesperidin, hesperetin, naringenin, naringin and quercetin), sulfur-containing compounds (S-allylcysteine, ergothioneine, lipoic acid and sulforaphane) and other compounds (betaine, caffeine, cucurbitacin B, lycopene, α-mangostin, γ-mangostin, ursolic acid, vitamin C and yangonin). The pharmacological effects and related mechanisms of these compounds in in-vivo and in-vitro models of liver fibrosis are focused.

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Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

Cited by 19 publications

References 43 publications

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Oliveria decumbens Extract Exhibits Hepatoprotective Effects Against Bile Duct Ligation-Induced Liver Injury in Rats by Reducing Oxidative Stress

A review of edible plant-derived natural compounds for the therapy of liver fibrosis

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