Lycopene and ellagic acid prevent testicular apoptosis induced by cisplatin

Abstract

The aim of this study was to investigate the possible protective effects of lycopene (LC) and ellagic acid (EA) on cisplatin (CP)-induced testicular apoptosis in male rats. The control group was treated with placebo; LC, EA and CP groups were given alone LC, EA and CP, respectively; the CP+LC group was treated with a combination of CP and LC; and the CP+EA group was treated with a combination of CP and EA. Although CP significantly increased the number of Bax-positive (apoptotic) cells it had no effect on the number of Bcl-2-positive (antiapoptotic) cells compared with the control group. Administration of CP caused significant increase in lipid peroxidation and nonsignificant decrease in superoxide dismutase (SOD) activity along with some histopathological lesions in testicular tissue. However, combined treatments of LC or EA in addition to CP tended to prevent the CP-induced testicular apoptosis, histopathological lesions and lipid peroxidation.

Anti-apoptotic Effect of Grape Seed Proanthocyanidin Extract on Cisplatin-induced Apoptosis in Rat Testis

“…In accordance with the reduction of organ weights and sperm concentration, histopathologic examination showed severe degeneration, necrosis in the testis of rats treated with CDDP alone, reflecting the testicular damage directly. Our findings are compatible with report of some researchers (Türk et al, 2011) and confirm the sperm toxic effects of CDDP in rats.…”

“…It has been known that exposure to CDDP (Türk et al, 2011) causes the rise of germ cell apoptotic rates. In the present study, Bcl-2 over-expression.…”

Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats

“…The antioxidant effects of EA on cytotoxicity have been evaluated by different studies. For example, it was reported that EA (2 mg/kg) can improve cyclophosphamide (CP)-induced testicular and liver damage by preventing lipid peroxidation and reducing apoptosis through scavenging ROS (Turk et al 2011). It was also reported that EA can regulate Cre and BUN concentrations, elevate the levels of glutathione (GSH), and reduce the necrotic lesions in renal tubular tissues (Atessahin et al 2007).…”

Erkek Ratlarda Maclura pomifera Ekstraktının Sisplatin ile Oluşturulmuş Üreme Sistemi Hasarı Üzerine Etkisi

“…Despite the fact that CP has a powerful effect on the destruction of neoplastic cells; it has also some dose-dependent side effects, including; cytotoxicity, nephrotoxicity [14,15] , hepatotoxicity [16] and reproductive toxicity [17] . The CP exposure can break the redox balance of tissues, suggesting that biochemical and physiological disturbances may result from the oxidative stress [18] . The ROS, like singlet molecular oxygen, superoxide anion, hydroxyl radical and hydrogen peroxide are normally produced in the subcellular compartments of testis, particularly within the mitochondria.…”

“…Various studies suggested that some antioxidant substances like lycopene, ellagic acid [18] , royal jelly [23] , melatonin [24] , roselle and ginger [25] and selenium [26] have all ameliorative effects against the CP-induced damages in the male reproductive system. However, in the literature, there appears no study available about the effect of maclura pomifera extract on the spermatological parameters in CP-exposed rats.…”