Luteolin protects against high fat diet-induced cognitive deficits in obesity mice

Liu, Yi; Fu, Xiangyu; Lan, Nuo; Li, Sai; Zhang, Jingzheng; Wang, Shuaishuai; Cheng, Li; Shang, Yanguo; Huang, Tonghui; Zhang, Ling

doi:10.1016/j.bbr.2014.02.040

Cited by 153 publications

(106 citation statements)

References 52 publications

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“…This robust association, which has been previously reviewed [12], has been described in various wild type mouse and rat models that have been exposed to a HF diet for between 1 month [13] and 8 months [14]. Among the various diets used in these experiments are 21% HF [15], 32% HF [16], 42% HF [17], 58% HF [18], 59.3% HF [19–21], 60% HF [22–25], and ‘HF, refined sugar’ [13,14,26,27]. Of these reports, only one found that HF diet exposure resulted in deficits in the Morris Water Maze without affecting body weight [27].…”

Section: Behavioral Phenotypesmentioning

confidence: 83%

Effects of high-fat diet exposure on learning & memory

Cordner

Tamashiro

2015

Physiology & Behavior

224

156

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The associations between consumption of a high-fat or ‘Western’ diet and metabolic disorders such as obesity, diabetes, and cardiovascular disease have long been recognized and a great deal of evidence now suggests that diets high in fat can also have a profound impact on the brain, behavior, and cognition. Here, we will review the techniques most often used to assess learning and memory in rodent models and discuss findings from studies assessing the cognitive effects of high-fat diet consumption. The review will then consider potential underlying mechanisms in the brain and conclude by reviewing emerging literature suggesting that maternal consumption of a high-fat diet may have effects on the learning and memory of offspring.

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Section: Behavioral Phenotypesmentioning

confidence: 83%

Effects of high-fat diet exposure on learning & memory

Cordner

Tamashiro

2015

Physiology & Behavior

224

156

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“…Morris water maze test: As previously described [29], the Morris water maze test was performed in a circular pool filled with water at room temperature (diameter, 120cm; height, 60cm; water temperature, 24 ± 1°C). An escape platform (10 cm in diameter) was hidden 1.5 cm below the surface of water in the center of one quadrant.…”

Section: Behavioral Testsmentioning

confidence: 99%

“…Increasing evidence has indicated that BDNF can affect synaptic plasticity by regulating the expression of synaptic proteins in the brain [29]. We examined if BDNF also changed with increased synaptic proteins after orientin treatment.…”

Section: Orientin Increases Bdnf Mrna and Protein Expression In The Bmentioning

confidence: 99%

Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noiseinduced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapseassociated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline. Disciplines Medicine and Health Sciences Publication DetailsWang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

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“…Reports have suggested that a selective interference with JNK activity presents an attractive opportunity for the treatment of IR [37]. Inflammation cytokines are important elements contributing to the pathogenesis and development of cognitive impairment, and increased levels of inflammatory can damage hippocampal synaptic plasticity [38].…”

Section: Discussionmentioning

confidence: 99%