The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling

Ma, Xiao; Fang, Fang; Song, Meiting; Ma, Shengming

doi:10.1016/j.bbrc.2015.07.081

Cited by 24 publications

(13 citation statements)

References 36 publications

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“…ILG also ameliorated the HFD-induced peripheral insulin resistance, which may results to neuronal damage and cognitive deficits, as measured by decreased plasma insulin and glucose levels. ILG treatment decreased the expression of TNF-α, p-JNK, IL-1β, p-IRSSer307 to reverse inflammation and insulin resistance ( Ma et al, 2015 ). This suggests that ILG has protective activity against the HFD caused learning and memory deficits through inhibition of the TNF-α/JNK/IRS pathway.…”

Section: Pharmacological Activities Against Nddsmentioning

confidence: 99%

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models

Mahesh

Kim

Lee

et al. 2018

Front. Aging Neurosci.

124

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The increasing lifespan in developed countries results in age-associated chronic diseases. Biological aging is a complex process associated with accumulated cellular damage by environmental or genetic factors with increasing age. Aging results in marked changes in brain structure and function. Age-related neurodegenerative diseases and disorders (NDDs) represent an ever-growing socioeconomic challenge and lead to an overall reduction in quality of life around the world. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are most common degenerative neurological disorders of the central nervous system (CNS) in aging process. The low levels of acetylcholine and dopamine are major neuropathological feature of NDDs in addition to oxidative stress, intracellular calcium ion imbalance, mitochondrial dysfunction, ubiquitin-proteasome system impairment and endoplasmic reticulum stress. Current treatments minimally influence these diseases and are ineffective in curing the multifunctional pathological mechanisms. Synthetic neuroprotective agents sometimes have negative reactions as an adverse effect in humans. Recently, numerous ethnobotanical studies have reported that herbal medicines for the treatment or prevention of NDDs are significantly better than synthetic drug treatment. Medicinal herbs have traditionally been used around the world for centuries. Radix Glycyrrhizae (RG) is the dried roots and rhizomes of Glycyrrhiza uralensis or G. glabra or G. inflata from the Leguminosae/Fabaceae family. It has been used for centuries in traditional medicine as a life enhancer, for the treatment of coughs and influenza, and for detoxification. Diverse chemical constituents from RG have reported including flavanones, chalcones, triterpenoid saponins, coumarines, and other glycosides. Among them, flavanone liquiritigenin (LG) and its precursor and isomer chalcone isoliquiritigenin (ILG) are the main bioactive constituents of RG. In the present review, we summarize evidence in the literature on the structure and phytochemical properties and pharmacological applications of LG and ILG in age-related diseases to establish new therapeutics to improve human health and lifespan.

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Section: Pharmacological Activities Against Nddsmentioning

confidence: 99%

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models

Mahesh

Kim

Lee

et al. 2018

Front. Aging Neurosci.

124

View full text Add to dashboard Cite

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“…The activation of JNK-1 interferes with insulin signaling via phosphorylation of IRS-1 on serine 307 (Ser307) residue [ 56 , 57 ]. IRS-1 is activated by insulin via tyrosine phosphorylation of IRS-1 in the normal signaling pathway, but the Ser307 phosphorylation of IRS decreases its ability to phosphorylate tyrosine and can therefore cause insulin resistance [ 57 – 59 ]. Hirosumi et al have reported that Ser307 phosphorylation of IRS-1 is increased in wild type obese mice, but not in Jnk1 −/− mice [ 57 ].…”

Section: Inflammation Of Obese Adipose Tissue and Insulin Resistanmentioning

confidence: 99%

“…Circulating levels of inflammatory factors including free fatty acids and TNF- α are higher in obesity [ 55 , 57 , 60 ]; these factors activate JNK-1, resulting in insulin resistance, as aforementioned [ 59 ]. It should be noted that TNF- α does not directly inhibit IRS-1.…”

Section: Inflammation Of Obese Adipose Tissue and Insulin Resistanmentioning

confidence: 99%

Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate

Norouzirad

González‐Muniesa

Ghasemi

2017

Oxidative Medicine and Cellular Longevity

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The prevalence of obesity and diabetes is increasing worldwide. Obesity and diabetes are associated with oxidative stress, inflammation, endothelial dysfunction, insulin resistance, and glucose intolerance. Obesity, a chronic hypoxic state that is associated with decreased nitric oxide (NO) bioavailability, is one of the main causes of type 2 diabetes. The hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of several genes of the metabolic pathways including proinflammatory adipokines, endothelial NO synthase (eNOS), and insulin signaling components. It seems that adipose tissue hypoxia and NO-dependent vascular and cellular dysfunctions are responsible for other consequences linked to obesity-related disorders. Although hyperoxia could reverse hypoxic-related disorders, it increases the production of reactive oxygen species (ROS) and decreases the production of NO. Nitrate can restore NO depletion and has antioxidant properties, and recent data support the beneficial effects of nitrate therapy in obesity and diabetes. Although it seems reasonable to combine hyperoxia and nitrate treatments for managing obesity/diabetes, the combined effects have not been investigated yet. This review discusses some aspects of tissue oxygenation and the potential effects of hyperoxia and nitrate interventions on obesity/diabetes management. It can be proposed that concomitant use of hyperoxia and nitrate is justified for managing obesity and diabetes.

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“…In another study of older adults, homeostatic model assessment of insulin resistance (HOMA-IR) and fasting insulin levels were negatively related to performance on a visuospatial memory task (Tan et al, 2011). In an animal model of induced IR by high-fat diet, learning and memory were impaired (Ma et al, 2015), suggesting a causal role of IR in memory impairment. Collectively, this evidence suggests that Glc hypometabolism and brain IR could be partial underlying causes for memory impairment in both AD and SZ.…”

Section: Introductionmentioning

confidence: 97%

Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia

Wijtenburg

Kapogiannis

Korenic

et al. 2019

Schizophrenia Research

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Memory is robustly impaired in schizophrenia (SZ) and related to functional outcome. Memory dysfunction has been shown to be related to altered brain glucose metabolism and brain insulin resistance in animal models and human studies of Alzheimer's disease. In this study, differences in brain glucose using magnetic resonance spectroscopy (MRS) and blood Extracellular Vesicle (EV) biomarkers of neuronal insulin resistance (i.e. Akt and signaling effectors) between SZ and controls were investigated, as well as whether these measures were related to memory impairments. Neuronal insulin resistance biomarkers showed a trend for being lower in SZ compared to controls, and memory measures were lower in SZ compared to controls. Occipital cortex glucose was higher in SZ compared to controls indicating lower brain glucose utilization. Linear regression analyses revealed significant relationships between neuronal insulin resistance biomarkers, memory measures, and brain glucose. More specifically, p70S6K, an insulin signaling effector, was related to verbal learning and brain MRS glucose in the SZ group. For the first time, we show that memory impairments in SZ may be related to brain glucose and brain insulin resistance. These data suggest that brain insulin resistance may play a role in the pathophysiology of learning and memory dysfunction in SZ.

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The effect of isoliquiritigenin on learning and memory impairments induced by high-fat diet via inhibiting TNF-α/JNK/IRS signaling

Cited by 24 publications

References 36 publications

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models

Hypoxia in Obesity and Diabetes: Potential Therapeutic Effects of Hyperoxia and Nitrate

Brain insulin resistance and altered brain glucose are related to memory impairments in schizophrenia

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