Effects of high-fat diet exposure on learning &amp; memory

Cordner, Zachary A.; Tamashiro, Kellie L.K.

doi:10.1016/j.physbeh.2015.06.008

Cited by 216 publications

(165 citation statements)

References 143 publications

(199 reference statements)

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“…Emerging epidemiological, clinical, or experimental evidence support the notion that cerebrovascular injury or dysfunction, particularly CAA, is critically involved in the incidence and development of AD. Furthermore, consumption of high‐fat Western diet has been suggested to be associated with the development of AD . However, at present, the potential effect of high‐fat‐diet intake on AD pathology is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…There has been solid evidence that long‐term high‐fat Western diet consumption causes an increased incidence of metabolic diseases such as obesity, diabetes, hyperinsulinemia, etc, and cardiovascular diseases. Furthermore, epidemiological and clinical data have suggested that high‐fat diet may contribute to the development of Alzheimer's disease (AD) or cognitive decline . Cross‐sectional study and longitudinal population‐based study provided the findings that intake of saturated fatty acid is correlated with impaired cognitive function.…”

Section: Introductionmentioning

confidence: 99%

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High‐Fat‐Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders

Lin

Hasegawa

Takane

et al. 2016

JAHA

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BackgroundThe high‐fat Western diet is postulated to be associated with the onset and progression of Alzheimer's disease (AD). However, the role of high‐fat‐diet consumption in AD pathology is unknown. This study was undertaken to examine the role of high‐fat‐diet intake in AD.Methods and Results5XFAD mice, a useful mouse model of AD, and control wild‐type mice were fed (1) high‐fat diet or (2) control diet for 10 weeks. The effects on cerebral AD pathology, cognitive function, and metabolic parameters were compared between each group of mice. High‐fat diet significantly enhanced cerebrovascular β‐amyloid (Aβ) deposition (P<0.05) and impaired cognitive function (P<0.05) in 5XFAD mice, but not in wild‐type mice. High‐fat diet enhanced hippocampal oxidative stress (P<0.05) and NADPH oxidase subunits, gp91phox (P<0.01) and p22phox (P<0.01) in 5XFAD mice, but not in wild‐type mice. Furthermore, high‐fat diet reduced cerebral occludin (P<0.05) in 5XFAD mice, but not in wild‐type mice. Thus, 5XFAD mice exhibited greater susceptibility to high‐fat diet than wild‐type mice regarding cerebrovascular injury and cognitive impairment. On the other hand, 5XFAD mice fed high‐fat diet exhibited much less increase in body weight, white adipose tissue weight, and adipocyte size than their wild‐type counterparts. High‐fat diet significantly impaired glucose tolerance in wild‐type mice but not in 5XFAD mice. Thus, 5XFAD mice had much less susceptibility to high‐fat‐diet‐induced metabolic disorders than wild‐type mice.ConclusionsHigh‐fat diet, independently of metabolic disorders, significantly promotes the progression of AD‐like pathology through enhancement of cerebral amyloid angiopathy and oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High‐Fat‐Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders

Lin

Hasegawa

Takane

et al. 2016

JAHA

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“…Evidence of a link between food intake and impaired memory performance is accumulating (for a review, see [23]). First, for the case of an overly rich diet, such as the Western diet, it has been shown that feeding rats a high-fat diet alters working memory, even after only 3 [77] or 9 days [110].…”

Section: Hippocampus and Memory For Food Intakementioning

confidence: 99%

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Coppin

2016

Physiology & Behavior

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• The amygdala and hippocampus play a major role in food intake and weight regulation.• These functions are far less known to cognitive and affective scientists.• This review uniquely expands on the interactions between these two brain structures. a b s t r a c t a r t i c l e i n f o The anterior medial temporal lobes are one of the most studied parts of the brain. Classically, their two main structures -the amygdalae and the hippocampi -have been linked to key cognitive and affective functions, related in particular to learning and memory. Based on abundant evidence, we will argue for an alternative but complementary point of view: they may also play a major role in food intake and body weight regulation. First, an overview is given of early clinical evidence in this line of thought. Subsequently, empirical evidence is presented on how food intake, including in the extreme case of obesity, may relate to amygdalian and hippocampal functioning. The focus is on the amygdala's role in processing the relevance of food stimuli, cue-induced feeding, and stress-induced eating and on the hippocampus' involvement in the use of interoceptive signals of hunger and satiety, as well as memory and inhibitory processes related to food intake. Additionally, an elaboration takes place on possible reciprocal links between food intake, body weight, and amygdala and hippocampus functioning. Finally, issues that seemed particularly critical for future research in the field are discussed.

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“…Clinical data suggests that high fat intake in all age groups negatively correlates with memory, cognitive flexibility, or executive functioning [12–14]. There is abundant evidence linking high fat diet (HFD) exposure to cognitive decline in the animal models [15–18]. Interestingly, even short-term exposure to HFD (< 20days) in the rodent has been shown to significantly impair performance on spatial working memory and object recognition tasks [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder

Chawla

Cordner

Boersma

et al. 2017

Physiology & Behavior

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Binge eating disorder (BED) is defined as recurrent, distressing over-consumption of palatable food (PF) in a short time period. Clinical studies suggest that individuals with BED may have impairments in cognitive processes, executive functioning, impulse control, and decision-making, which may play a role in sustaining binge eating behavior. These clinical reports, however, are limited and often conflicting. In this study, we used a limited access rat model of binge-like behavior in order to further explore the effects of binge eating on cognition. In binge eating prone (BEP) rats, we found novel object recognition (NOR) as well as Barnes maze reversal learning (BM-RL) deficits. Aberrant gene expression of brain derived neurotrophic factor (Bdnf) and tropomyosin receptor kinase B (TrkB) in the hippocampus (HPC)-prefrontal cortex (PFC) network was observed in BEP rats. Additionally, the NOR deficits were correlated with reductions in the expression of TrkB and insulin receptor (Ir) in the CA3 region of the hippocampus. Furthermore, up-regulation of serotonin-2C (5-HT2C) receptors in the orbitoprefrontal cortex (OFC) were associated with BM-RL deficit. Finally, in the nucleus accumbens (NAc), we found decreased dopamine receptor 2 (Drd2) expression among BEP rats. Taken together, these data suggest that binge eating vegetable shortening may induce contextual and reversal learning deficits which may be mediated, at least in part, by the altered expression of genes in the CA3-OFC-NAc neural network.

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Effects of high-fat diet exposure on learning & memory

Cited by 216 publications

References 143 publications

High‐Fat‐Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders

High‐Fat‐Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder

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