Lung cancer mortality in Montenegro, 1990 to 2015

Nedović-Vuković, Mirjana; Laušević, Dragan; Ljaljević, Agima; Golubović, Mileta; Trajković, Goran

doi:10.3325/cmj.2019.60.26

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Only 17.7% of the patients who are diagnosed with lung cancer live more than 5 years. Most patients with NSCLC are diagnosed in the advanced stages, and the overall 5-year survival rate is low due to its recurrence and metastasis (2)(3)(4)(5)(6). Therefore, there is an urgent need to explore the mechanisms of NSCLC and to find effective biomarkers for prognostic evaluation and therapy.…”

Section: Introductionmentioning

confidence: 99%

DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas

et al. 2020

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DEK has been revealed to be overexpressed in many cancers and associated with cancer progression. The aim of the present study was to elucidate the role of DEK with a specific focus on its underlying mechanism in lung cancers. DEK expression in lung cancers and normal lung tissues and the correlations between DEK expression and clinicopathological parameters of lung cancers were investigated using the data from The Cancer Genome Atlas (TCGA). DEK expression was upregulated by DEK transfection or downregulated by DEK shRNA interference in A549 and H1299 cells. The effects of DEK on the Wnt signaling pathway and epithelial-mesenchymal transition (EMT) were examined using western blotting. Proliferative and invasive abilities were observed in A549 and H1299 cells treated with DEK using an MTT assay, colony formation assay, and Transwell migration and invasion assays. The expression of DEK was higher in lung cancer tissues than that in normal lung tissues. DEK expression was positively correlated with the expression of epidermal growth factor receptor (EGFR) and KRAS in lung adenocarcinomas. High expression of DEK indicated poor prognosis in lung adenocarcinomas (P=0.018). Enhanced expression of DEK upregulated the levels of active-β-catenin and Wnt target genes, such as cyclin D1, c-Myc and MMP7 and increased the proliferative and invasive abilities of lung cancer cells. Enhanced expression of DEK in A549 and H1299 cells also increased the levels of EGFR, KRAS, vimentin, Snail, and N-cadherin, and decreased the level of E-cadherin. The opposite results were obtained with knockdown of DEK expression. DEK was highly expressed in lung cancers and indicated poor prognosis in lung adenocarcinomas. DEK expression activated the Wnt signaling pathway and EMT process and promoted the proliferation and invasion of lung cancers.

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Section: Introductionmentioning

confidence: 99%

DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas

et al. 2020

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“…The mortality trends in lung cancer in the United States have gradually decreased [ 27 ]. Mortality rates increased from 1990 by 3.91% per year and decreased from 2004 by 1.95% in Montenegro [ 28 ]. Some studies have observed a sharp increase in the lung cancer mortality rate since 2000 in China [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term Changes in the Premature Death Rate in Lung Cancer in a Developed Region of China: Population-based Study

Ye¹,

Lu²,

Li³

et al. 2022

JMIR Public Health Surveill

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Background Lung cancer is a leading cause of death worldwide, and its incidence shows an upward trend. A study of the long-term changes in the premature death rate in lung cancer in a developed region of China has great exploratory significance to further clarify the effectiveness of intervention measures. Objective This study examined long-term changes in premature lung cancer death rates in order to understand the changes in mortality and to design future prevention plans in Pudong New Area (PNA), Shanghai, China. Methods Cancer death data were collected from the Mortality Registration System of PNA. We analyzed the crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), and years of life lost (YLL) of patients with lung cancer from 1973 to 2019. Temporal trends in the CMR, ASMRW, and YLL rate were calculated by joinpoint regression expressed as an average annual percentage change (AAPC) with the corresponding 95% CI. Results All registered permanent residents in PNA (80,543,137 person-years) from 1973 to 2019 were enrolled in this study. There were 42,229 deaths from lung cancer. The CMR and ASMRW were 52.43/105 and 27.79/105 person-years, respectively. The YLL due to premature death from lung cancer was 481779.14 years, and the YLL rate was 598.16/105 person-years. The CMR and YLL rate showed significantly increasing trends in men, women, and the total population (P<.001). The CMR of the total population increased by 2.86% (95% CI 2.66-3.07, P<.001) per year during the study period. The YLL rate increased with an AAPC of 2.21% (95% CI 1.92-2.51, P<.001) per year. The contribution rates of increased CMR values caused by demographic factors were more evident than those caused by nondemographic factors. Conclusions Lung cancer deaths showed an increasing trend in PNA from 1973 to 2019. Demographic factors, such as the aging population, contributed more to an increased CMR. Our research can help us understand the changes in lung cancer mortality and can be used for similar cities in designing future prevention plans.

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“…Germany also had a 2.3% increase in the rate of female lung cancer, but the highest rate of growth was in the Netherlands, which had a 4.6% increase in cancer rates among women [ 5 ]. Italy showed a 1.8% reduction in lung cancer among men and a 1.2% increase in women [ 5 ]; in Montenegro, an increase of 3.9% between the years 1990 and 2004 and a decrease of 1.95% between 2015 and 2015 was detected [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Clustering Trend Changes of Lung Cancer Incidence in Europe via the Growth Mixture Model during 1990–2016

Boroujeni

Mehrabani

Shahraki

2021

Journal of Environmental and Public Health

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Background. Lung cancer accounts for half of all deaths from cancer in Europe and has the highest incidence in Southern Europe. The current study aimed to cluster trend changes of lung cancer incidence in Europe via the growth mixture model. Methods. The dataset included incidence rates of female and male lung cancer per 100,000 for 42 European countries during 1990–2016 compiled from the Gapminder database. The growth mixture model was implemented to recognize different longitudinal patterns and estimate the linear trend of each pattern in Mplus 7.4 software. Results. The observed overall trend of incidence for female and male lung cancer was raising and falling, respectively, and Iceland was the only country with higher incidence of female versus male lung cancer in 2016. The growth mixture model suggests 3 main patterns for the trend of lung cancer incidence both for males and females. In male lung cancer, a sharp decreasing pattern was detected for 6 countries including Belarus, Estonia, Russia, Slovenia, Ukraine, and the United Kingdom; also, a moderately decreasing pattern was observed among the other countries. In female lung cancer, a moderate increasing trend was observed for 8 countries including the United Kingdom, Denmark, Hungary, Iceland, Ireland, Montenegro, Netherlands, and Norway; the other patterns were categorized into two clusters with slow increasing trends. Conclusion. Given the raising patterns in the incidence of lung cancer among European females, especially in the United Kingdom, Denmark, Hungary, Iceland, Ireland, Montenegro, Netherlands, and Norway, urgent effective measures are recommended to be taken.

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Lung cancer mortality in Montenegro, 1990 to 2015

Cited by 5 publications

References 17 publications

DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas

DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas

Long-term Changes in the Premature Death Rate in Lung Cancer in a Developed Region of China: Population-based Study

Clustering Trend Changes of Lung Cancer Incidence in Europe via the Growth Mixture Model during 1990–2016

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