Long-term Changes in the Premature Death Rate in Lung Cancer in a Developed Region of China: Population-based Study

Ye, Wenjing; Lu, Wei-Wei; Li, Xiaopan; Chen, Yichen; Wang, Lin; Zeng, Guangwang; Xu, Cheng; Ji, Chen; Cai, Yuyang; Yang, Ling; Luo, Zheng

doi:10.2196/33633

Cited by 8 publications

(8 citation statements)

References 25 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Crude mortality rate and YLL had a significant increase in men, women and the general population. The crude mortality rate in the total population increased by 2.86% per year during the study period ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Trend Analysis of Lung Cancer Mortality and Years of Life Lost (YLL) in South of Iran, 2004-2019

Azarbakhsh,

Rezaei,

Dehghani

et al. 2024

ijph

View full text Add to dashboard Cite

Background: We aimed to determine the mortality rate and Years of Life Lost (YLL) due to lung cancer in Fars, Iran, during the period from 2004 to 2019. Methods: All deaths due to lung cancer in Fars Province, Iran from the electronic population-based death registration system (EDRS) were obtained. Crude mortality rate, age-standardized mortality rate, YLL and YLL rate data were calculated and trends examined. Results: During 2004-2019, 3346 deaths occurred due to lung cancer in Fars Province, which was 10.8% (3346/30936) of the total cancer deaths in this period. Crude mortality rate of lung cancer had increased 70% and 53% in male and female respectively from 2004 to 2019. The total YLL of lung cancer during the 16-year study period was 28,094 (0.9 per 1000) in men, 14,174 (0.5 per 1000) in women, and 42,268 (0.8 per 1000) in both sexes (sex ratio male/female=2). According to the join point regression, the 16- year trend of YLL rate due to premature mortality was increasing: APC was 2.5% (95% CI 0.9 to 4.2, P=0.005) for males, 1.4% (95% CI 0.3 to 2.6, P=0.017) for females. Conclusion: The mortality rate and YLL due to lung cancer in Fars Province is increasing, although the standardized mortality has a constant trend. Tobacco control is the most effective and least expensive way to reduce the number of lung cancer patients worldwide. National and local media can also play an important role in informing people about the risk factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Trend Analysis of Lung Cancer Mortality and Years of Life Lost (YLL) in South of Iran, 2004-2019

Azarbakhsh,

Rezaei,

Dehghani

et al. 2024

ijph

View full text Add to dashboard Cite

show abstract

“…According to the de nition of the World Health Organization (WHO), a country whose population over 65 years old exceeds 7% of the total population is called an ageing society, 14% is called an aged society, and up to 20% is called a hyperaged society. In terms of the proportion of the registered population aged 65 or above, Pudong has been an ageing society since 1982 (7.72%), an aged society since 2008 (14.21%), approached the standard of a hyperaged society in 2017 (19.78%), and entered a hyperaged society in 2018 (20.81%) (Ye et al 2022). It took only a decade for Pudong to transition to a hyperaged society from an aged society.…”

Section: Discussionmentioning

confidence: 99%

“…With rapid demographic and economic transitions, the burden of noncommunicable diseases (NCDs) in low-and middleincome countries (LMICs), especially in China, has generally increased (Zhou et al 2019). Pudong, Shanghai is one of the most economically developed regions in China with the fastest urbanization and a hyperaged society, which has become the symbol of the modernization of Shanghai as well as the reforms and opening up of China (Ye et al 2022). Changes in epidemiological data in Pudong could be used as a representative of studies related to ageing and urbanization processes.…”

Section: Introductionmentioning

confidence: 99%

The effect of hypertensive diseases on death patterns and healthy ageing in Pudong, Shanghai: a population-based study

Zou

Wang

Chen

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Hypertensive diseases (HT) have become one of the leading causes of death among older people in developing countries, but data on HT-related deaths and HT-specific deaths in the whole population in the context of healthy ageing have not been well studied. We analysed the HT-related death and HT-specific death spectrum, crude mortality rate (CMR), age-standardized mortality rate by Segi’s world standard population (ASMRW), years of life lost (YLL) and age-specific proportion and then used the Joinpoint Regression Program to analyse the trends. We also studied the mortality rate increases by demographic age structure factors by the decomposition method. Of all 110,393 HT-related deaths, there were 5,757 HT-specific deaths in Pudong, Shanghai, from 2005–2020. The CMR, ASMRW, YLL and YLL rates of HT-related deaths (and HT-specific deaths) were 244.73/105 (12.76/105) person-years, 79.86/105 (4.22/105) person-years, 846,645.55 (43,912.98) years and 1,876.94/105 (97.35/105), respectively. The top 3 common causes of death among HT-related deaths (and HT-specific deaths) were cerebrovascular disease (heart disease), heart disease (renal failure) and diabetes mellitus (cerebrovascular disease). The HT-related and HT-specific CMR increased with age and year (all P < 0.05). The age-specific mortality rates decreased in age group 70–79 years, while in other groups, they increased or stabilized. The CMR caused by demographic age structure factors increased in the two groups (all P < 0.05). Our study provides new insights into the mortality trend of HT in a hyperaged society. As a common disease among older people, the burden of HT requires further study to meet the needs of healthy ageing.

show abstract

“…Lung cancer, which is a leading reason of death and has been reported to have a great prevalence of newly diagnosed about 3 million cases and 2 million deaths only in 2020 globally, only has 18% for 5‐year survival rate in the patient. 1 Therapy for lung cancer is primarily dependent on cancer staging, history, immunotherapy biomarker testing, and health status. Therapy includes surgical resection, immunotherapy, chemotherapy, and radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

TXNL4B regulates radioresistance by controlling the PRP3‐mediated alternative splicing of FANCI

Zhao

Jing

Xiao

et al. 2023

MedComm

View full text Add to dashboard Cite

Ionizing radiation (IR) has been extensively used for cancer therapy, but the radioresistance hinders and undermines the radiotherapy efficacy in clinics greatly. Here, we reported that the spliceosomal protein thioredoxin‐like 4B (TXNL4B) is highly expressed in lung tissues from lung cancer patients with radiotherapy. Lung cancer cells with TXNL4B knockdown illustrate increased sensitivity to IR. Mechanistically, TXNL4B interacts with RNA processing factor 3 (PRP3) and co‐localizes in the nucleus post‐IR. Nuclear localization of PRP3 promotes the alternative splicing of the Fanconi anemia group I protein (FANCI) transcript variants, FANCI‐12 and FANCI‐13. PRP3 regulates alternative splicing of FANCI toward the two variants, FANCI‐12 and FANCI‐13. Radioresistance was greatly enhanced through the combination of PRP31 and PRP8, the critical components of core spliceosome promoted by PRP3. Notably, the inhibition of PRP3 to suppress the production of FANCI‐12 would deprive PRP31 and PRP8 of such interaction. As a result, cell cycle G2/M arrest was induced, DNA damage repair was delayed, and radiosensitivity was improved. Collectively, our study highlights potential novel underlying mechanisms of the involvement of TXNL4B and alternative splicing in radioresistance. The results would benefit potential cancer radiotherapy.

show abstract

Long-term Changes in the Premature Death Rate in Lung Cancer in a Developed Region of China: Population-based Study

Cited by 8 publications

References 25 publications

Trend Analysis of Lung Cancer Mortality and Years of Life Lost (YLL) in South of Iran, 2004-2019

Trend Analysis of Lung Cancer Mortality and Years of Life Lost (YLL) in South of Iran, 2004-2019

The effect of hypertensive diseases on death patterns and healthy ageing in Pudong, Shanghai: a population-based study

TXNL4B regulates radioresistance by controlling the PRP3‐mediated alternative splicing of FANCI

Contact Info

Product

Resources

About