Lung Cancer in Women

MacRosty, Christina R.; Rivera, M. Patricia

doi:10.1016/j.ccm.2019.10.005

Cited by 52 publications

(21 citation statements)

References 58 publications

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“…Men present an approximately two-times higher risk of mortality from all cancers than women; different outcomes based on sex are particularly relevant for lung, melanoma, larynx, esophagus, and bladder cancers [ 1 ]. Gender differences in this context depend not only on biological, environmental, and hormonal factors but also on immune system, and all of these aspects are strictly interconnected [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer

Vavalà¹,

Catino

Pizzutilo

et al. 2021

IJMS

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In developed countries, lung cancer is the leading cause of cancer-related death in both sexes. Although cigarette smoking represents the principal risk factor for lung cancer in females, the higher proportion of this neoplasm among non-smoking women as compared with non-smoking men implies distinctive biological aspects between the two sexes. Gender differences depend not only on genetic, environmental, and hormonal factors but also on the immune system, and all these aspects are closely interconnected. In the last few years, it has been confirmed that the immune system plays a fundamental role in cancer evolution and response to oncological treatments, specifically immunotherapy, with documented distinctions between men and women. Consequently, in order to correctly assess cancer responses and disease control, considering only age and reproductive status, the results of studies conducted in female patients would probably not categorically apply to male patients and vice versa. The aim of this article is to review recent data about gender disparities in both healthy subjects’ immune system and lung cancer patients; furthermore, studies concerning gender differences in response to lung cancer immunotherapy are examined.

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Section: Introductionmentioning

confidence: 99%

Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer

Vavalà¹,

Catino

Pizzutilo

et al. 2021

IJMS

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“…Unfortunately, we could not explore the reasons behind this finding; further research is required. However, previous studies have posited that sex-based differences in biological responses to exposures and hormonal factors may account for observed excess lung cancer risk in women 39,40 …”

Section: Discussionmentioning

confidence: 99%

Occupational Exposures and Lung Cancer Risk—An Analysis of the CARTaGENE Study

Moayedi-Nia

Pasquet²,

Siemiatycki³

et al. 2022

Journal of Occupational &Amp; Environmental Medicine

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Objective:To determine the associations between prevalent occupational agents and lung cancer risk.Methods:A case-cohort design (ncases= 147; nsub-cohort= 1,032) was nested within the CARTaGENE prospective cohort study. The Canadian Job Exposure Matrix was used to determine the probability of exposure to 27 agents in participants’ longest-held jobs. Multivariable logistic regression with robust variance estimators was used to determine the associations between each agent and lung cancer risk while adjusting for established lung cancer risk factors.Results:Increased lung cancer risk was observed among those exposed to ashes, calcium sulfate, formaldehyde, cooking fumes, alkanes, aliphatic aldehydes, and cleaning agents. Lower lung cancer risk was found among participants exposed to carbon monoxide and polycyclic aromatic hydrocarbons from petroleum.Conclusion:Our findings support the role of several occupational agents, for which we have limited knowledge, in contributing to lung cancer risk.

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“…Female mice were chosen for study because while both naive male and female C57BL/6 mice do not present lung function differences at baseline [55], tumors grow more rapidly in female C57BL/6 mice [56]. In addition, to date, worldwide statistics indicate biological sex differences in human lung cancer, with higher lung cancer incidence rates for women [57]. A Lewis lung carcinoma (LLC) cell line was used in this study as a murine model of non-small cell lung cancer (NSCLC), since it is highly tumorigenic and provides a reproducible syngeneic model for lung cancer in the C57BL mouse [58][59][60].…”

Section: Animal Model Of Lung Cancermentioning

confidence: 99%

Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer

Terracciano

Carcamo-Bahena

Butler

et al. 2021

Preprint

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Biofouling is the unwanted adsorption of cells, proteins, or intracellular and extracellular bio-molecules that can spontaneously occur on the surface of metal nanocomplexes. It represents a major issue in bioinorganic chemistry because it leads to the creation of a protein corona, which can destabilize a colloidal solution and result in undesired macrophage-driven clearance, consequently causing failed delivery of a targeted drug-cargo. Hyaluronic acid (HA) is a bioactive, natural mucopolysaccharide with excellent antifouling properties, arising from its hydrophilic and polyanionic characteristics in physiological environments which prevent opsonization. In this study, hyaluronate-thiol (HA-SH) (MW 10 kDa) was used to surface-passivate gold nanoparticles (GNPs) synthesized using a citrate reduction method. HA functionalized GNP complexes (HA-GNPs) were characterized using absorption spectroscopy, scanning electron microscopy, zeta potential, and dynamic light scattering. GNP cellular uptake and potential dose-dependent cytotoxic effects due to treatment were evaluated in vitro in HeLa cells using ICP-OES and Trypan blue and MTT assays. Further, we quantified the in vivo biodistribution of intratumorally injected HA functionalized GNPs in Lewis Lung carcinoma (LLC) solid tumors grown on the flank of C57BL/6 mice and compared localization and retention with nascent particles. Our results reveal that HA-GNPs show overall greater peritumoral distribution (**p<0.005, 3 days post-intratumoral injection) than citrate-GNPs with reduced biodistribution in off-target organs. This property represents an advantageous step forward in localized delivery of metal nano-complexes to the infiltrative region of a tumor, which may improve the application of nanomedicine in the diagnosis and treatment of cancer.

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Lung Cancer in Women

Cited by 52 publications

References 58 publications

Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer

Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer

Occupational Exposures and Lung Cancer Risk—An Analysis of the CARTaGENE Study

Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer

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