Occupational Exposures and Lung Cancer Risk—An Analysis of the CARTaGENE Study

Moayedi-Nia, Saeedeh; Pasquet, Romain; Siemiatycki, Jack; Koushik, Anita; Ho, Vikki

doi:10.1097/jom.0000000000002481

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…These findings suggest that gender-specific factors could modify the impact of this genetic variant on lung cancer susceptibility. Hormonal variations [ 26 , 27 ], lifestyle preferences [ 28 – 31 ], or occupational exposures [ 32 – 34 ] are potential contributors to this gender-associated effect. Nonetheless, the underlying mechanisms and biological basis for these gender disparities remain unclear and require further investigation.…”

Section: Discussionmentioning

confidence: 99%

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Xie,

Huang,

Zhou

et al. 2024

Discov Onc

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Background Lung cancer, with its high morbidity and mortality, presents a major significant public health challenge. CD147, linked to cancer progression and metastasis, is a promising therapeutic target, including for lung cancer. The genetic variation may influence the expression of the gene and consequently the risk of lung cancer. This study aims to investigate single nucleotide polymorphisms (SNPs) in CD147 to understand their association with the risk of developing lung cancer in the Han Chinese population. Methods A hospital-based case–control investigation was conducted, enrolling 700 lung cancer patients and 700 cancer-free controls. TagSNPs were selected using Haploview v4.2, and genotype data from the 1000 Genomes Project database were utilized. The selected SNPs (rs28992491, rs67945626, and rs79361899) within the CD147 gene were evaluated using the improved multiple ligation detection reaction method. Statistical analysis included chi-square tests, logistic regression models, and interaction analyses. Results Baseline characteristics of the study population showed no significant differences in gender distribution between cases and controls, but there was a notable difference in smoking rates. No significant associations were found between the three TagSNPs and lung cancer susceptibility in the codominant model. However, stratification analyses revealed interesting findings. Among females, the rs79361899 AA/AG genotype was associated with an increased risk of lung cancer. In individuals aged ≥ 65 years old, the rs28992491 GG and rs79361899 AA genotypes were linked to a higher susceptibility. Furthermore, an interaction analysis demonstrated significant genotype × gender interactions in the rs79361899 recessive model, indicating an increased lung cancer risk in female carriers of the heterozygous or homozygous polymorphic genotype. Conclusions CD147 polymorphisms play an important role in lung cancer development, particularly in specific subgroup of age and gender. These findings highlight the significance of incorporating genetic variations and their interactions with demographic factors in comprehending the intricate etiology of lung cancer.

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Section: Discussionmentioning

confidence: 99%

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Xie,

Huang,

Zhou

et al. 2024

Discov Onc

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show abstract

“…Furthermore, a sensitivity analysis, called “leave-one-out”, was conducted by leaving out one SNP at a time to assess if a single SNP had a disproportionate effect on the overall estimation. Finally, we searched on the PhenoScanner3 website ( http://www.phenoscanner.medschl.cam.ac.uk ) to investigate the presence of SNPs linked to any confounding factors, including smoking behaviors ( 32 – 34 ), sedentary behaviors and physical activity ( 35 , 36 ), educational attainment ( 37 ), anti-oxidants ( 38 ), dietary intake and food supplement intake ( 39 ), and job of participants ( 40 ), which have been identified as common risk factors of respiratory diseases. If any were found, we eliminated these SNPs and replicated the IVW analysis to evaluate the robustness of the results.…”

Section: Methodsmentioning

confidence: 99%

Tea intake and lung diseases: a Mendelian randomization study

Wu,

Jiao,

Shu

et al. 2024

Front. Immunol.

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BackgroundExisting studies on the relationship between tea intake and lung diseases have yielded inconsistent results, leading to an ongoing dispute on this issue. The impact of tea consumption on the respiratory system remained elucidating.Materials and methodsWe conducted a two-sample Mendelian randomization (MR) study to evaluate the associations between five distinct tea intake phenotypes and 15 different respiratory outcomes using open Genome-wide association study (GWAS) data. The inverse variance weighted (IVW) was used for preliminary screening and a variety of complementary methods were used as sensitivity analysis to validate the robustness of MR estimates. Pathway enrichment analysis was used to explore possible mechanisms.ResultsIVW found evidence for a causal effect of standard tea intake on an increased risk of lung squamous cell cancer (LSCC) (OR = 1.004; 95% CI = 1.001–1.007; P = 0.00299). No heterogeneity or pleiotropy was detected. After adjustment for potential mediators, including smoking, educational attainment, and time spent watching television, the association was still robust in multivariable MR. KEGG and GO enrichment predicted proliferation and activation of B lymphocytes may play a role in this causal relation. No causalities were observed when evaluating the effect of other kinds of tea intake on various pulmonary diseases.ConclusionOur MR estimates provide causal evidence of the independent effect of standard tea intake (black tea intake) on LSCC, which may be mediated by B lymphocytes. The results implied that the population preferring black tea intake should be wary of a higher risk of LSCC.

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“…Tobacco exposure stands undoubtedly as a leading common denominator shared by the two diseases; however, it must be considered that only about 30% of smokers eventually develop clinically significant COPD, while 10-15% develop lung cancer [37]. In a similar manner, occupational as well as particulate matter (PM) exposure represent major risk factors for both LC and COPD [38][39][40][41]. Moreover, the scenario is by far more complicated.…”

Section: Copd and Lung Cancermentioning

confidence: 99%

Comorbidities in COPD: Current and Future Treatment Challenges

Mariniello,

D’Agnano,

Cennamo

et al. 2024

JCM

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Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition, primarily characterized by the presence of a limited airflow, due to abnormalities of the airways and/or alveoli, that often coexists with other chronic diseases such as lung cancer, cardiovascular diseases, and metabolic disorders. Comorbidities are known to pose a challenge in the assessment and effective management of COPD and are also acknowledged to have an important health and economic burden. Local and systemic inflammation have been proposed as having a potential role in explaining the association between COPD and these comorbidities. Considering that the number of patients with COPD is expected to rise, understanding the mechanisms linking COPD with its comorbidities may help to identify new targets for therapeutic purposes based on multi-dimensional assessments.

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Occupational Exposures and Lung Cancer Risk—An Analysis of the CARTaGENE Study

Cited by 9 publications

References 38 publications

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Tea intake and lung diseases: a Mendelian randomization study

Comorbidities in COPD: Current and Future Treatment Challenges

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