Abstract:Luminol-dependent chemiluminescence and thiol group oxidation of glutathione and human serum albumin were measured in order to demonstrate whether the inhibition of polymorphonuclear leukocyte chemiluminescence by albumin was attributable to thiol group oxidation. We have shown that: 1. thiol groups on glutathione and albumin are oxidized by PMNL stimulated by soluble and phagocytic stimuli; 2. thiol group oxidation in albumin and glutathione did not correlate with the inhibitory effects of these substances on… Show more
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