&lt;title&gt;Effects of rectangular microchannel aspect ratio on laminar friction constant&lt;/title&gt;

Papautsky, Ian; Gale, Bruce K.; Mohanty, Swomitra K.; Ameel, Tim; Frazier, A. Bruno

doi:10.1117/12.359332

Cited by 65 publications

(48 citation statements)

References 22 publications

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“…The Reynolds number at which the thermal behavior indicates a transition from laminar to turbulent flow has also differed widely in these studies. Possible reasons advanced to account for the deviation from classical theory have included surface roughness [4], electrical double layer [5] and aspect ratio [6] effects. The capability of Navier-Stokes equations to adequately represent the flow and heat transfer behavior in microchannels has been called into question in some of these studies.…”

Section: Introductionmentioning

confidence: 99%

Investigation of heat transfer in rectangular microchannels

Lee

Garimella

Liu

2005

International Journal of Heat and Mass Transfer

716

295

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An experimental investigation was conducted to explore the validity of classical correlations based on conventional-sized channels for predicting the thermal behavior in single-phase flow through rectangular microchannels. The microchannels considered ranged in width from 194 m to 534 m, with the channel depth being nominally five times the width in each case. Each test piece was made of copper and contained ten microchannels in parallel. The experiments were conducted with deionized water, with the Reynolds number ranging from approximately 300 to 3500. Numerical predictions obtained based on a classical, continuum approach were found to be in good agreement with the experimental data (showing an average deviation of 5 percent), suggesting that a conventional analysis approach can be employed in predicting heat transfer behavior in microchannels of the dimensions considered in this study. However, the entrance and boundary conditions imposed in the experiment need to be carefully matched in the predictive approaches.

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Section: Introductionmentioning

confidence: 99%

Investigation of heat transfer in rectangular microchannels

Lee

Garimella

Liu

2005

International Journal of Heat and Mass Transfer

716

295

View full text Add to dashboard Cite

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“…A commonly used analytical description of flow characteristics in microinjectors allowed us to design our devices. [27][28][29][30] Flow rate Q per applied pressure DP through a microchannel is given by…”

Section: Mems-based Injection Systemmentioning

confidence: 99%

“…28 Calculated steady-state flow rates per applied pressure for two different needle designs are reported in Table 1. The dynamic viscosity of water, m water = 10 23 N s m 22 at 20uC was used.…”

Section: Mems-based Injection Systemmentioning

confidence: 99%

Automated MEMS-based Drosophila embryo injection system for high-throughput RNAi screens

et al. 2006

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We have developed an automated system based on microelectromechanical systems (MEMS) injectors for reliable mass-injection of Drosophila embryos. Targeted applications are high-throughput RNA interference (RNAi) screens. Our injection needles are made of silicon nitride. The liquid to be injected is stored in an integrated 500 nl reservoir, and an externally applied air pressure pulse precisely controls the injected volume. A steady-state water flow rate per applied pressure of 1.2 nl s 21 bar 21 was measured for a needle with channel width, height and length of 6.1 mm, 2.3 mm and 350 mm, respectively. A typical volume of 60 pl per embryo can be reliably and rapidly delivered within tens of milliseconds. Theoretical predictions of flow rates match measured values within ¡10%. Embryos are attached to a glass slide surface and covered with oil. Packages with the injector chip and the embryo slide are mounted on motorized xyz-stages. Two cameras allow the user to quickly align the needle tip to alignment marks on the glass slide. Our system then automatically screens the glass slide for embryos and reliably detects and injects more than 98% of all embryos. Survival rates after deionized (DI) water injection of 80% and higher were achieved. A first RNAi experiment was successfully performed with double-stranded RNA (dsRNA) corresponding to the segment polarity gene armadillo at a concentration of 0.01 mM. Almost 80% of the injected embryos expressed an expected strong loss-of-function phenotype. Our system can replace current manual injection technologies and will support systematic identification of Drosophila gene functions.

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“…It was shown that microfluidic-based systems have a great potential in application for single-cell analysis [1,2] and instant analyses or so called point-of-care (POC) diagnostics [3][4][5]. In this respect, microfluidics systems provide conditions that are comparable to in vivo conditions [1].…”

Section: Introductionmentioning

confidence: 99%

“…Microchannel geometry and surface texture are considered as the crucial factors in determining fluid flow through microchannels. These factors mainly depend on microfabrication techniques and fabrication processes of the microchannels [2][3][4].…”

Section: Introductionmentioning

confidence: 99%