&lt;p&gt;The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis&lt;/p&gt;

Zhou, Zhongbao; Song, Shiqiang; Gao, Zhenli; Wu, Jitao; Ma, Jiajia; Cui, Yuanshan

doi:10.2147/cia.s192435

Cited by 56 publications

(35 citation statements)

References 27 publications

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“…The frontal area also showed a significant response, but less than that of the vertex, which is consistent with many previous reports [17,18]. In previous studies, the vertex type of AGA showed a more rapid and obvious improvement with oral 1 mg finasteride compared with the other areas [18,19].…”

Section: Discussionsupporting

confidence: 91%

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

Panchaprateep

Lueangarun

2020

Dermatol Ther (Heidelb)

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Introduction: Oral minoxidil is an antihypertensive vasodilator known to stimulate hair growth. The use of low-dose oral minoxidil for the treatment of male androgenetic alopecia (AGA) is receiving increasing attention. The aim of this study was to evaluate the efficacy and safety of oral minoxidil for the treatment of male AGA. Methods: This was an open-label, prospective, single-arm study. Thirty men aged 24-59 years with AGA types III vertex to V were treated with oral minoxidil 5 mg once daily for 24 weeks. Efficacy was evaluated by hair counts, hair diameter measurements, photographic assessment, and self-administered questionnaire. The safety of the treatment was closely monitored by means of physical examinations and laboratory investigations. Results: There was a significant increase in total hair counts from baseline at weeks 12 (mean change ? 26, range 182.5-208.5 hairs/ cm 2) and 24 (mean change ? 35.1, range 182.5-217.6 hairs/cm 2) (both p = 0.007). Photographic assessment of the vertex area by an expert panel revealed 100% improvement (score [ ? 1), with 43% of patients showing excellent improvement (score ? 3, 71-100% increase). The frontal area also showed a significant response but less than that of the vertex area. Common side effects were hypertrichosis (93% of patients) and pedal edema (10%). No serious cardiovascular adverse events and abnormal laboratory findings were observed. Conclusion: Oral minoxidil 5 mg once daily effectively increased hair growth in our male patients with AGA and had a good safety profile in healthy subjects. However, oral minoxidil should be used carefully with men who have severe hypertension and increased risk for cardiovascular events.

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Section: Discussionsupporting

confidence: 91%

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

Panchaprateep

Lueangarun

2020

Dermatol Ther (Heidelb)

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“…In addition to finasteride, a 5α-R2 inhibitor, a novel molecule called dutasteride has recently been developed which is able to affect both 5α-R1 and 5α-R2. Oral dutasteride (0.5 mg/day) is another option, but there are no studies that compare its efficacy to that of finasteride [24]. MXD was originally developed as an antihypertensive agent, but attracted interest as a potential HL therapy; indeed, patients treated with MXD developed generalized hypertrichosis [25].…”

Section: Traditional Medical Treatmentsmentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…DHT subsequently binds to AR, enhancing the transcription of the catagen inducer, TGFβ . Inhibition of 5αR is targeted in treatment of AGA (eg Finasteride), though alternative AGA therapies include androgen antagonists …”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 99%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

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Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

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<p>The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis</p>

Cited by 56 publications

References 27 publications

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

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